Journal
CELL
Volume 160, Issue 6, Pages 1222-1232Publisher
CELL PRESS
DOI: 10.1016/j.cell.2015.02.024
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Funding
- NIH [DP1 DK006850, R01AG040236, P01NS062686]
- American Diabetes Association
- Helmholtz Society (ICEMED)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil [CNPq: 401476/2012-0]
- Brain and Behavior Research Foundation
- NCATS [UL1 TR000142]
- CNPq, Brazil [487096/2013-4]
- Science Without Borders fellowship from CNPq/Brazil
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The nervous system evolved to coordinate flexible goal-directed behaviors by integrating interoceptive and sensory information. Hypothalamic Agrp neurons are known to be crucial for feeding behavior. Here, however, we show that these neurons also orchestrate other complex behaviors in adult mice. Activation of Agrp neurons in the absence of food triggers foraging and repetitive behaviors, which are reverted by food consumption. These stereotypic behaviors that are triggered by Agrp neurons are coupled with decreased anxiety. NPY5 receptor signaling is necessary to mediate the repetitive behaviors after Agrp neuron activation while having minor effects on feeding. Thus, we have unmasked a functional role for Agrp neurons in controlling repetitive behaviors mediated, at least in part, by neuropeptidergic signaling. The findings reveal a new set of behaviors coupled to the energy homeostasis circuit and suggest potential therapeutic avenues for diseases with stereotypic behaviors.
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