Cu(OAc)2-catalyzed hydrazination of cyclopropanols and late-stage transformation to 4,5-dihydropyrazoles

A low-cost and commercially available Cu(OAc)(2) catalyzed hydrazination of cyclopropyl alcohols is developed. This procedure featured mild reaction conditions and good to excellent yields, providing a feasible method for the preparation of hydrazine derivatives. One of the hydrazine compounds then underwent a one-pot two-step reaction to yield 4,5-dihydropyrazoles. Furthermore, encouraging antifungal activity was demonstrated by the hydrazine and 4,5-dihydropyrazole core structures.

Automated summary

A low-cost and commercially available Cu(OAc)(2) catalyzed hydrazination of cyclopropyl alcohols was developed, providing a feasible method for the preparation of hydrazine derivatives. The hydrazine compound could further undergo a one-pot two-step reaction to yield 4,5-dihydropyrazoles. Furthermore, the hydrazine and 4,5-dihydropyrazole core structures showed encouraging antifungal activity.