Journal
NEW JOURNAL OF CHEMISTRY
Volume 47, Issue 1, Pages 220-223Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2nj04082d
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Funding
- Program for Science and Technology Development of Henan
- Key Natural Science Research Program of Education Department of Henan
- [212102310883]
- [21B150013]
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A one-pot synthesis for the preparation of 1,2,3,4-tetrahydroacridines involving a Zr(iv)-catalyzed Mannich reaction of o-azidobenzaldehydes and arylamines with cycloketones, followed by aza-Witting cyclization and deaminative aromatization, is developed. This method can be extended for the synthesis of cyclohepta[b]quinolines.
A one-pot synthesis for the preparation of 1,2,3,4-tetrahydroacridines involving a Zr(iv)-catalyzed Mannich reaction of o-azidobenzaldehydes and arylamines with cycloketones, followed by aza-Witting cyclization and deaminative aromatization, is developed. This method can be extended for the synthesis of cyclohepta[b]quinolines.
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