4.4 Article

Acute morphine injection persistently affects the electrophysiological characteristics of rat locus coeruleus neurons

Journal

NEUROSCIENCE LETTERS
Volume 795, Issue -, Pages -

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2023.137048

Keywords

Opiate; Locus coeruleus; Patch-clamp recording; Action potential; Synaptic transmission; Orexin-A

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Administration of morphine can lead to dependence and tolerance, even after a single dose. This study found that acute exposure to morphine significantly decreases the spontaneous firing rate of locus coeruleus (LC) neurons, as well as alters the action potential characteristics.
Administration of morphine is associated with critical complications in clinic which primarily includes the development of dependence and tolerance even following a single dose (acute) exposure. Behavioral and elec-trophysiological studies support the significant role of locus coeruleus (LC) neurons in tolerance and dependence following chronic morphine exposure. The current study was designed to explore the electrophysiological properties of the LC neurons following acute morphine exposure. In-vitro whole-cell patch-clamp recordings were performed in LC neurons 24 h after intraperitoneal morphine injection. Acute morphine injection signifi-cantly decreased the spontaneous firing rate of LC neurons, the rising and decay slopes of action potentials, and consequently increased the action potential duration. In addition, morphine treatment did not alter the rheobase current and first spike latency while affected the inhibitory postsynaptic currents elicited in response to orexin-A. In fact, single morphine exposure could inhibit the disinhibitory effect of orexin-A on LC neurons.

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