Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 143, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2022.104964
Keywords
Delusional disorder; Schizophrenia; Psychosis; First episode of psychosis; suicide
Categories
Funding
- Agencia de Gestio d'Ajuts Universitaris i de Recerca
- Generalitat de Catalunya [2017 SGR 632]
- Intensification of the Research Activity Grant from the Carlos III Health Institute (Ministry of Science and Innovation, Government of Spain) [INT21/00055]
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This study found differences in rates of suicide attempts and completed suicide among individuals with schizophrenia, schizoaffective disorder, delusional disorder, and first-episode psychosis. The rates varied by diagnosis, clinical setting, and geographical region. Northern European countries reported higher rates of completed suicide in studies of schizophrenia and first-episode psychosis.
We studied the prevalence of suicide attempts and cumulative incidence of completed suicide in schizophrenia (SZ), schizoaffective disorder (SZAF), delusional disorder (DD) and first-episode psychosis (FEP). A systematic review was performed using Scopus and PubMed databases (1990- July 2020). A random effects meta-analysis was conducted. Stratified analyses were conducted by diagnosis, clinical setting and geographical region. The prevalence of attempted suicide was 20.3% for SZ, 46.8% for SZAF, 11.1% for DD and 12.5% for FEP. Suicide attempts rates were higher for outpatient samples than for inpatient samples in SZ, SZAF and DD (but not FEP) studies. Analyses by geographical region in SZ showed greater prevalence of suicide attempts in North America and Northern Europe. The cumulative incidence of completed suicide was 2.0% for SZ, 2.4% for SZAF; 2.2% for DD and 1.9% for FEP. In schizophrenia and FEP studies, Northern European studies reported higher rates of completed suicide when compared to Western European countries. In conclusion, suicidal behaviour rates in psychoses differ by diagnoses, clinical setting and geographical region
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