Related references
Note: Only part of the references are listed.Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
Anika Reifschneider et al.
EMBO JOURNAL (2022)
TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration
Manling Xie et al.
NATURE NEUROSCIENCE (2022)
Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
Ethan R. Roy et al.
IMMUNITY (2022)
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
Julia Tcw et al.
CELL (2022)
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity
Matheus B. Victor et al.
CELL STEM CELL (2022)
APOE interacts with tau PET to influence memory independently of amyloid PET in older adults without dementia
Alexandra J. Weigand et al.
ALZHEIMERS & DEMENTIA (2021)
NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large- scale multi-subject single-cell data
Liang He et al.
COMMUNICATIONS BIOLOGY (2021)
Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
Seung-Hye Lee et al.
NEURON (2021)
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy
Sandro Da Mesquita et al.
NATURE (2021)
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia
Chao Wang et al.
NEURON (2021)
Microglia in Alzheimer's disease at single-cell level. Are there common in humans and mice?
Yun Chen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2021)
Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms
Yang Shi et al.
NEURON (2021)
Activated microglia mitigate Aβ-associated tau seeding and spreading
Maud Gratuze et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2021)
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal
Jingyue Jia et al.
DEVELOPMENTAL CELL (2020)
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease
Yingyue Zhou et al.
NATURE MEDICINE (2020)
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
Alicia A. Nugent et al.
NEURON (2020)
Association of Apolipoprotein E epsilon 4 With Medial Temporal Tau Independent of Amyloid-beta
Joseph Therriault et al.
JAMA NEUROLOGY (2020)
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease
Aivi T. Nguyen et al.
ACTA NEUROPATHOLOGICA (2020)
Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
Nicholas F. Fitz et al.
MOLECULAR NEURODEGENERATION (2020)
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration
Maud Gratuze et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression
Jessica E. Rexach et al.
CELL REPORTS (2020)
Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease
Min Seok Baek et al.
ALZHEIMERS RESEARCH & THERAPY (2020)
The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
Carlo Sala Frigerio et al.
CELL REPORTS (2019)
Comprehensive Integration of Single-Cell Data
Tim Stuart et al.
CELL (2019)
Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors
Zoe P. Van Acker et al.
MOLECULAR NEURODEGENERATION (2019)
TREM2 function impedes tau seeding in neuritic plaques
Cheryl E. G. Leyns et al.
NATURE NEUROSCIENCE (2019)
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
Renzo Mancuso et al.
BRAIN (2019)
Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy
Tiffany Wu et al.
CELL REPORTS (2019)
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model
Yang Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
NLRP3 inflammasome activation drives tau pathology
Christina Ising et al.
NATURE (2019)
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle
Khalid Arhzaouy et al.
AUTOPHAGY (2019)
Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders
Enrique Gabande-Rodriguez et al.
EMBO JOURNAL (2019)
A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes
Kirill Bersuker et al.
DEVELOPMENTAL CELL (2018)
ApoE facilitates the microglial response to amyloid plaque pathology
Jason D. Ulrich et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease
Paul J. Cheng-Hathaway et al.
MOLECULAR NEURODEGENERATION (2018)
Neurofilaments as biomarkers in neurological disorders
Michael Khalil et al.
NATURE REVIEWS NEUROLOGY (2018)
Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
Faten A. Sayed et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies
Borislav Dejanovic et al.
NEURON (2018)
Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease
Alexandra Litvinchuk et al.
NEURON (2018)
Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight
Yang Shi et al.
NATURE REVIEWS IMMUNOLOGY (2018)
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann et al.
IMMUNITY (2017)
Glial contributions to neurodegeneration in tauopathies
Cheryl E. G. Leyns et al.
MOLECULAR NEURODEGENERATION (2017)
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
Shane M. Bemiller et al.
MOLECULAR NEURODEGENERATION (2017)
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
Yang Shi et al.
NATURE (2017)
TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
Cheryl E. G. Leyns et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
Hansruedi Mathys et al.
CELL REPORTS (2017)
The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
Tal Nuriel et al.
FRONTIERS IN NEUROSCIENCE (2017)
Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and Lysophagy
Chrisovalantis Papadopoulos et al.
CURRENT BIOLOGY (2017)
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
Hadas Keren-Shaul et al.
CELL (2017)
Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation
Wilbur Song et al.
ALZHEIMERS & DEMENTIA (2017)
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
Yaming Wang et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2016)
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
Felix L. Yeh et al.
NEURON (2016)
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Itay Tirosh et al.
SCIENCE (2016)
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
Yuka Atagi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
Taylor R. Jay et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
Spatial reconstruction of single-cell gene expression data
Rahul Satija et al.
NATURE BIOTECHNOLOGY (2015)
Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models
Fan Liao et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
Jason D. Ulrich et al.
MOLECULAR NEURODEGENERATION (2014)
Identification of a unique TGF-β dependent molecular and functional signature in microglia
Oleg Butovsky et al.
NATURE NEUROSCIENCE (2014)
Lysosome: regulator of lipid degradation pathways
Carmine Settembre et al.
TRENDS IN CELL BIOLOGY (2014)
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
Michela Palmieri et al.
HUMAN MOLECULAR GENETICS (2011)
Alzheimer's Disease: The Challenge of the Second Century
David M. Holtzman et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Lysosomal Lipid Storage Diseases
Heike Schulze et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)
Alzheimer Disease
Rudy J. Castellani et al.
DM DISEASE-A-MONTH (2010)
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
Yasumasa Yoshiyama et al.
NEURON (2007)
Cutting edge: TREM-2 attenuates macrophage activation
Isaiah R. Turnbull et al.
JOURNAL OF IMMUNOLOGY (2006)
Share Paper
