Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases

Review Cell Biology

Pervasive role of the long noncoding RNA DNM3OS in development and diseases

Sandy Fellah et al.

Summary: This article summarizes the functions of the noncoding RNA DNM3OS in diseases and its potential as a novel therapeutic target.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2023)

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Review Allergy

Translation and emerging functions of non-coding RNAs in inflammation and immunity

Elena Della Bella et al.

Summary: Regulatory non-coding RNAs have received considerable attention in recent years due to their condition- and tissue-specific expression and various modes of action. Translation of short open reading frames is an important mechanism for these RNAs to regulate gene expression. However, the study of translational regulation through regulatory RNAs is still limited.

ALLERGY (2022)

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Article Engineering, Biomedical

Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo

David Rufino-Ramos et al.

Summary: The lack of techniques to trace brain cell behavior limits the ability to monitor their status. Extracellular vesicles (EVs), released by brain cells, might be able to report their status. However, identifying brain-derived EVs in complex biofluids is challenging. This study developed a sensitive platform to isolate pre-labelled brain-derived EVs from blood, allowing for the study of molecular fingerprints of brain cells.

BIOMATERIALS (2022)

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Article Medicine, Research & Experimental

Novel anti-aging herbal formulation Jing Si displays pleiotropic effects against aging associated disorders

Marthandam Asokan Shibu et al.

Summary: This study evaluated the effects of a herbal drink on aging-related disorders and found that it maintains stem cell homeostasis, provides cytoprotection, regulates blood glucose metabolism, enhances autophagic clearances in neurons, and suppresses cancer growth and migration.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Pharmacology & Pharmacy

Inflammation, ageing and diseases of the lung: Potential therapeutic strategies from shared biological pathways

Aduragbemi A. Faniyi et al.

Summary: Lung diseases have a greater impact on elderly individuals due to the vulnerability of the lungs to age-related changes and inflammation. Despite different causes, the burden of aging and inflammation exacerbates seemingly unrelated pathologies, but also offers a common route to treatment.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

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Article Cell Biology

Transcription factor NFIC functions as a tumor suppressor in lung squamous cell carcinoma progression by modulating lncRNA CASC2

Hong Zhang et al.

Summary: This study reveals the tumor-suppressive role of NFIC in LUSC by inhibiting cell proliferation, promoting cell apoptosis, and suppressing cell migration and invasion. The study also uncovers the relationship between NFIC and lncRNA CASC2, suggesting that CASC2 may play a key role in LUSC development.

CELL CYCLE (2022)

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Review Biochemistry & Molecular Biology

The various regulatory functions of long noncoding RNAs in apoptosis, cell cycle, and cellular senescence

Mohammad Heydarnezhad Asl et al.

Summary: Long noncoding RNAs (lncRNAs) play regulatory roles in important biological processes such as apoptosis, cell cycle, and cellular senescence. Dysregulation of lncRNAs is implicated in tumor formation and other diseases.

JOURNAL OF CELLULAR BIOCHEMISTRY (2022)

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Article Genetics & Heredity

LncRNA-mRNA co-expression network revealing the regulatory roles of lncRNAs in melanogenesis in vitiligo

Kunchi Pang et al.

Summary: In vitiligo, there are significant alterations in the expression of upregulated and downregulated lncRNAs, which play a role in regulating melanocyte function and melanogenesis. A total of 14 aberrantly expressed lncRNAs have been identified to regulate genes related to melanogenesis, suggesting their involvement in pathological mechanisms in melanocytes in vitiligo.

JOURNAL OF HUMAN GENETICS (2022)

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Article Biology

Novel insights from a multiomics dissection of the Hayflick limit

Michelle Chan et al.

Summary: This study investigates the process of replicative senescence in cells using modern techniques and finds that the transition to a senescent state occurs early, gradually increases, and is associated with a global increase in DNA accessibility. The study also shows that senescent cells exhibit similarities to myofibroblasts and undergo a process similar to epithelial-mesenchymal transition (EMT), regulated by YAP1/TEAD1 and TGF-beta 2. Finally, the study demonstrates that inhibiting YAP1/TEAD1 activity can attenuate the gene expression program in aged cells.

ELIFE (2022)

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Article Genetics & Heredity

FlyPhoneDB: an integrated web-based resource for cell-cell communication prediction in Drosophila

Yifang Liu et al.

Summary: Researchers have developed FlyPhoneDB, a tool that predicts cell-cell communication events in Drosophila by calculating interaction scores for ligand-receptor interactions. By applying FlyPhoneDB to single-cell RNA sequencing datasets from Drosophila, active ligands and receptors can be effectively identified to uncover cell-cell communication pathways.

GENETICS (2022)

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Review Cell Biology

Adult stem cell niches for tissue homeostasis

Giuliana Mannino et al.

Summary: Adult stem cells are essential for tissue homeostasis, growth, and regeneration, residing in specialized environments called niches. Interactions within the niche, including intrinsic factors, supporting cells, extracellular matrix, and signaling pathways, govern cell fate and regulate proliferation and differentiation. Tissues can be classified based on their turnover rate and repair abilities, with stem cell niches playing a crucial role in tissue maintenance and response to injury or disease.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Article Genetics & Heredity

Effects of PAMK on lncRNA, miRNA, and mRNA expression profiles of thymic epithelial cells

Qingru Wu et al.

Summary: Polysaccharides from Atractylodes macrocephala Koidz (PAMK) promote the proliferation of mouse medullary thymic epithelial cells, potentially involving the involvement of lncRNAs and miRNAs.

FUNCTIONAL & INTEGRATIVE GENOMICS (2022)

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Article Genetics & Heredity

Down-regulation of long non-coding RNAs in reproductive aging and analysis of the lncRNA-miRNA-mRNA networks in human cumulus cells

Angela Caponnetto et al.

Summary: This study identified differentially expressed lncRNAs in cumulus cells (CCs) from aged women and proposed ceRNA-networks involved in signaling pathways crucial in ovarian folliculogenesis and female germ cell maturation. The down-regulation of lncRNAs in aged women's CCs could influence the expression of genes associated with reproductive aging. Understanding the interplay of lncRNA-miRNA-mRNA networks in human CCs could lead to the development of new therapeutics and improve reproductive outcomes in aged women.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2022)

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Article Medical Laboratory Technology

Involvement of blood lncRNA UCA1 in sepsis development and prognosis, and its correlation with multiple inflammatory cytokines

Jingmei Wang et al.

Summary: The study found that lncRNA UCA1 is upregulated in sepsis patients and correlates with multiple pro-inflammatory cytokines, disease severity, and poor prognosis.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2022)

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Article Biochemistry & Molecular Biology

The dynamic kidney matrisome-is the circadian clock in control?

Rebecca Preston et al.

Summary: The circadian clock network in mammals is responsible for regulating various physiological processes in the body. Kidney disease is associated with the circadian system and extracellular matrix. Recent evidence suggests that cell-matrix interactions and the biomechanical properties of the matrix play a crucial role in regulating peripheral circadian rhythms. Studying the kidney matrisome can provide insights into the interactions between the extracellular matrix and intracellular time-keeping mechanisms.

MATRIX BIOLOGY (2022)

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Review Cell Biology

Sources, resolution and physiological relevance of R-loops and RNA-DNA hybrids

Eva Petermann et al.

Summary: RNA-DNA hybrids and R-loop structures play important roles in transcription, replication, and DNA repair. They regulate gene expression and chromatin structure but can also cause genome instability and contribute to diseases such as neurodegeneration and cancer. Therefore, understanding and targeting R-loop suppression mechanisms provide therapeutic opportunities.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Review Cell Biology

Current methods to analyze lysosome morphology, positioning, motility and function

Duarte C. Barral et al.

Summary: This review presents current methods used to analyze lysosome morphology, positioning, motility, and function, discussing the strategies for identifying and assessing lysosome characteristics and functions. It aims to stimulate further research on lysosomes and encourage groundbreaking discoveries on this intriguing organelle that continues to surprise and excite cell biologists.

TRAFFIC (2022)

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Review Biochemistry & Molecular Biology

Consequences of telomere replication failure: the other end-replication problem

Kirsten A. Brenner et al.

Summary: Telomeres are protective structures at the ends of chromosomes, but they can cause obstacles during replication. Replication stress triggers telomere repair mechanisms, which are error prone and primarily used in tumorigenic contexts. Research suggests that fragile telomeres are ultimately tumor-suppressive and may not require repair.

TRENDS IN BIOCHEMICAL SCIENCES (2022)

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Article Multidisciplinary Sciences

Bloom helicase mediates formation of large single-stranded DNA loops during DNA end processing

Chaoyou Xue et al.

Summary: Bloom syndrome is a genetic disorder associated with increased cancer risk caused by mutations in the Bloom helicase. This study investigates the mechanisms used by BLM helicase as it initiates the repair of broken chromosomes.

NATURE COMMUNICATIONS (2022)

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Review Neurosciences

Roles of Long Non-coding RNAs in the Development of Aging-Related Neurodegenerative Diseases

Yu-Qing Ni et al.

Summary: Aging-related neurodegenerative diseases are a major burden on society and are closely associated with mitochondrial dysfunction, inflammation, and oxidative stress. Emerging evidence suggests that lncRNAs play critical regulatory roles in the initiation and development of neurodegenerative diseases.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

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Article Biotechnology & Applied Microbiology

Lamin A and telomere maintenance in aging: Two to Tango

Duhita Sengupta et al.

Summary: Lamin proteins play a crucial role in aging and diseases like progeria. Mutations in LMNA gene lead to the accumulation of progerin and cause accelerated cellular senescence. Defects in laminar organization can result in loss of genomic integrity and telomere attrition, accelerating physiological aging.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2022)

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Review Genetics & Heredity

Regulation of Non-Coding RNA in the Growth and Development of Skeletal Muscle in Domestic Chickens

Hongmei Shi et al.

Summary: This review summarizes the ncRNAs involved in the skeletal muscle growth and development of domestic chickens and discusses the potential limitations and challenges.

GENES (2022)

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Article Oncology

Long Noncoding RNA SNHG16 Regulates the Growth of Human Lung Cancer Cells by Modulating the Expression of Aldehyde Dehydrogenase 2 (ALDH2)

Yan Li et al.

Summary: This study investigates the role and therapeutic potential of lncRNA SNHG16 in human lung cancer. The results show that upregulation of SNHG16 is associated with increased lung cancer cell proliferation, migration, and invasion, while downregulation of SNHG16 inhibits these processes. SNHG16 interacts with ALDH2 to exert its effects in lung cancer cells. Additionally, the expression of ALDH2 is suppressed in lung cancer tissues and cell lines. Overall, this study uncovers the molecular role of SNHG16 in regulating the development of lung cancer by interacting with ALDH2.

JOURNAL OF ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

LINC00892 Is an lncRNA Induced by T Cell Activation and Expressed by Follicular Lymphoma-Resident T Helper Cells

Ingram Iaccarino et al.

Summary: LINC00892, a non-coding transcript, is highly expressed in Jurkat cells following cell activation. Its expression pattern resembles genes involved in T cell memory and it is primarily expressed in effector memory and helper CD4+ T cell sub-types, but not in naive T cells. In situ analysis shows that LINC00892 is expressed in CD4+ PD1(hi) T cells, with a subcellular localization within the germinal center matching follicular helper T cells. Thus, LINC00892 could serve as a useful biomarker for detecting CD4+ memory T cells in both normal and tumor tissues.

NON-CODING RNA (2022)

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Review Biochemistry & Molecular Biology

Role of Non-coding RNAs in Axon Regeneration after Peripheral Nerve Injury

Ming Liu et al.

Summary: Peripheral nerve injury can cause disability and neuropathic pain, resulting in a significant economic burden. The ability of the peripheral nervous system to regenerate after injury is influenced by the expression of non-coding RNAs, particularly microRNAs, long non-coding RNAs, and circular RNAs. This article reviews the cellular and molecular mechanisms of axon regeneration after peripheral nerve injury and discusses the roles and functions of these non-coding RNAs in nerve repair.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Long Non-Coding RNAs as Emerging Regulators of Pathogen Response in Plants

Yashraaj Sharma et al.

Summary: Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential that play important roles in plant survival by regulating gene expression through epigenetic changes, transcription, and post-transcription. In particular, lncRNAs have diverse mechanisms in plant growth, development, and stress responses, with a focus on their potential against biotic stress. Further research is needed to better understand the functions and molecular mechanisms of lncRNAs in plant responses to pathogens.

NON-CODING RNA (2022)

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Review Genetics & Heredity

Interpreting the impact of noncoding structural variation in neurodevelopmental disorders

Eva D'haene et al.

Summary: Novel sequencing technologies have improved the identification of structural variants in the human genome, revealing a large number of such variants. These variants primarily impact noncoding DNA sequences, and understanding how they affect gene regulation presents a significant challenge.

GENETICS IN MEDICINE (2021)

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Review Chemistry, Multidisciplinary

A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids

Nicolo Zuin Fantoni et al.

Summary: Click chemistry, particularly azide-alkyne cycloadditions, is a powerful technique for the covalent conjugation of molecular entities. Its application in nucleic acid chemistry allows efficient and cost-effective labeling, ligation, and cyclization of oligonucleotides compared to traditional techniques. This review provides a guide to researchers approaching the field, discussing the chemistry and applications of AAC reactions in nucleic acids.

CHEMICAL REVIEWS (2021)

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Article Biochemistry & Molecular Biology

nc886, a Non-Coding RNA, Is a New Biomarker and Epigenetic Mediator of Cellular Senescence in Fibroblasts

Yuna Kim et al.

Summary: Functional studies have shown that epigenetic changes can impact aging significantly. Non-coding RNA nc886 plays a key role in cellular senescence, with decreased expression associated with aging and potential for suppression of senescence. AbsoluTea Concentrate 2.0 (ATC) can increase nc886 expression and inhibit cellular senescence by targeting age-related biomarkers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Immunology

Analysis of Long Non-Coding RNA in Cryptosporidium parvum Reveals Significant Stage-Specific Antisense Transcription

Yiran Li et al.

Summary: Cryptosporidium, a parasite causing severe diarrhea in children, has a complex lifecycle and its gene regulation mechanism is not well understood. A recent study identified 396 novel long non-coding RNAs (lncRNAs) associated with parasite development, most of which are antisense and show differential expression. These lncRNAs may play critical roles in parasite development and host-pathogen interactions.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Plant Sciences

Vegetable Grafting From a Molecular Point of View: The Involvement of Epigenetics in Rootstock-Scion Interactions

Aphrodite Tsaballa et al.

Summary: Vegetable grafting is widely used in agricultural production to control pathogens and stresses, as well as improve phenotypic characteristics. Molecular interactions between grafting partners through genomics and epigenetics can significantly affect plant performance and growth.

FRONTIERS IN PLANT SCIENCE (2021)

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Review Medicine, General & Internal

Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes

Nurruzanna Ismail et al.

Summary: The discovery of non-coding RNAs as potential biomarkers for disease progression, particularly in type 2 diabetes (T2D) and cardiovascular disease (CVD), highlights the importance of understanding the roles of long non-coding RNAs (lncRNAs) in these conditions. Utilizing lncRNAs as early diagnostic molecular biomarkers for CVD complications in T2D patients shows promise for future clinical applications.

DIAGNOSTICS (2021)

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Article Oncology

The double-edged sword of H19 lncRNA: Insights into cancer therapy

Yun Wei Shermane Lim et al.

Summary: H19 long non-coding RNA has dual roles in cancer, acting as both an oncogene and a suppressor gene in tumor development. It plays a crucial role in cancer therapy through various mechanisms, including its applications in recombinant vectors, chemoresistance, epigenetic regulation, alteration of tumor microenvironment, and cancer immunotherapy, as well as its relationship with the tumor suppressor gene p53.

CANCER LETTERS (2021)

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Review Clinical Neurology

UBE3A reinstatement as a disease-modifying therapy for Angelman syndrome

Ype Elgersma et al.

Summary: Angelman syndrome, caused by mutations in the maternally inherited UBE3A gene, remains a rare disease without effective treatments. Strategies targeting critical substrates of UBE3A and restoring UBE3A protein levels are highly anticipated for disease modification.

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY (2021)

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Review Biotechnology & Applied Microbiology

Yarrowia lipolytica: a multitalented yeast species of ecological significance

Dmitry Mamaev et al.

Summary: Yarrowia lipolytica is characterized by its ecological advantages, such as versatility in environmental pollutant degradation and plant growth promotion. Engineered strains show promise in producing valuable compounds.

FEMS YEAST RESEARCH (2021)

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Article Medicine, Research & Experimental

CRISPR/Cas9 directed to the Ube3a antisense transcript improves Angelman syndrome phenotype in mice

Ralf S. Schmid et al.

Summary: Gene editing technology shows potential in treating Angelman syndrome in a mouse model by partially correcting behavioral phenotypes. This therapeutic approach aims to unsilence the paternal gene in neurons, providing lasting therapeutic effects for patients with AS.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Oncology

Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma

Arantxa Carrasco-Leon et al.

Summary: In this study, researchers identified a large number of novel lncRNAs in MM, which showed more heterogeneous expression compared to coding genes, and were associated with the biological and clinical behavior of the disease. Through the study of lncRNAs, potential biomarkers related to MM progression and survival rates were discovered.

LEUKEMIA (2021)

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Review Endocrinology & Metabolism

Association of lncRNA with regulatory molecular factors in brain and their role in the pathophysiology of schizophrenia

Parinita Mishra et al.

Summary: Research has shown that the association of schizophrenia with the high expression level of long noncoding RNA (lncRNA) in the brain plays a significant role in the proper functioning of neurons, neurotransmitters, and synapses, which are often found dysfunctional in schizophrenia.

METABOLIC BRAIN DISEASE (2021)

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Review Genetics & Heredity

Review Evolutionary conservation in noncoding genomic regions

Nicole A. Leypold et al.

Summary: Research suggests that humans may share more genomic commonalities with other species than previously thought, including a significant fraction of conserved noncoding elements. As whole-genome sequencing becomes a standard procedure in genetic analyses, the interpretation of variations in these conserved elements is becoming increasingly necessary.

TRENDS IN GENETICS (2021)

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Article Genetics & Heredity

Functional Network of the Long Non-coding RNA Growth Arrest-Specific Transcript 5 and Its Interacting Proteins in Senescence

Siqi Wang et al.

Summary: Studies have shown that GAS5 plays a crucial role in brain aging, affecting processes such as cell proliferation and apoptosis. GAS5 may also be associated with senescence-related diseases such as Parkinson's and Alzheimer's.

FRONTIERS IN GENETICS (2021)

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Article Oncology

Long non-coding RNAs at work on telomeres: Functions and implications in cancer therapy

Kavita Gala et al.

Summary: Long non-coding RNAs (lncRNAs) play a significant role in telomere length maintenance in cancer, with TERC and TERRA being crucial lncRNAs involved in this process. TERC and TERRA regulate telomere length by interacting with telomerase, having implications in precision oncology.

CANCER LETTERS (2021)

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Article Biochemistry & Molecular Biology

Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease

Olivia M. de Goede et al.

Summary: This study systematically characterized 14,100 lncRNA genes across 49 tissues for 101 complex genetic traits using GTEx project data, identifying 1,432 lncRNA gene-trait associations, 800 of which were not explained by neighboring protein-coding genes. The findings revealed associations between lncRNA and various diseases and traits.

CELL (2021)

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Review Biotechnology & Applied Microbiology

The emerging regulatory roles of long non-coding RNAs implicated in cancer metabolism

Yongcan Xu et al.

Summary: This review focuses on the relationship between dysregulated long non-coding RNAs (lncRNAs) and cancer metabolism, particularly emphasizing the specific roles of lncRNAs in glycolysis, mitochondrial function, glutamine, and lipid metabolism. These investigations highlight the key role of lncRNAs in the complexity of malignant cancer metabolism, suggesting that understanding the relevance between lncRNAs and cancer metabolic reprogramming could lead to new approaches in cancer diagnosis and treatment.

MOLECULAR THERAPY (2021)

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Article Cell Biology

LncRNA-HOTAIR activates autophagy and promotes the imatinib resistance of gastrointestinal stromal tumor cells through a mechanism involving the miR-130a/ATG2B pathway

Jinyan Zhang et al.

Summary: This study revealed that HOTAIR targets the ATG2B inhibitor miR-130a to upregulate cell autophagy levels, promoting imatinib resistance in GIST cells.

CELL DEATH & DISEASE (2021)

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Review Oncology

miRNAs and lncRNAs as Novel Therapeutic Targets to Improve Cancer Immunotherapy

Maria Teresa Di Martino et al.

Summary: Cancer onset and progression are influenced by immune system dysregulation, with noncoding RNAs playing a role in cancer cell immune escape and modulation of the tumor microenvironment. While immunotherapy holds promise for cancer treatment, efforts are needed to achieve cure for immune-refractory tumors.

CANCERS (2021)

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Review Cell Biology

The Power of Stress: The Telo-Hormesis Hypothesis

Maria Sol Jacome Burbano et al.

Summary: Adaptive response to stress is a survival strategy conserved across evolution. Scientists have explored the potential benefits of changing telomeres in response to stress, suggesting stress-induced telomere signaling with hormetic effects.

CELLS (2021)

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Review Cell Biology

Telomere Replication: Solving Multiple End Replication Problems

Erin Bonnell et al.

Summary: Telomeres, crucial for maintaining genomic stability, pose challenges for replication due to their repetitive nature and the formation of secondary structures, leading to replication fork stalling. Multiple mechanisms are involved in overcoming these obstacles to ensure efficient telomeric DNA duplication and preserve genome integrity.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Andrology

Comprehensive analysis of the lncRNA-miRNA-mRNA regulatory network for bladder cancer

Minyu Huang et al.

Summary: This study identified a novel competing endogenous RNA network for bladder cancer and found that it significantly affects the prognosis of bladder cancer patients. Functional enrichment analyses revealed biological functions related to negative regulation of protein phosphorylation and cell morphogenesis, as well as cancer pathways such as MAPK signaling and transforming growth factor-beta signaling pathway.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

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Article Cell Biology

mascRNA and its parent lncRNA MALAT1 promote proliferation and metastasis of hepatocellular carcinoma cells by activating ERK/MAPK signaling pathway

Shu-Juan Xie et al.

Summary: The study reveals that MALAT1-associated small cytoplasmic RNA (mascRNA) is upregulated in multiple cancer cell lines and hepatocellular carcinoma (HCC) clinical samples, promoting cell proliferation, migration, and invasion in HCC cells. Both mascRNA and its parent lncRNA MALAT1 activate the ERK/MAPK signaling pathway, contributing to the aggressive phenotype of HCC cells.

CELL DEATH DISCOVERY (2021)

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Article Cell Biology

Anticancer effects of melatonin via regulating lncRNA JPX-Wnt/β-catenin signalling pathway in human osteosarcoma cells

Yuan Li et al.

Summary: This study found that melatonin inhibits the biological functions of osteosarcoma (OS) cells by repressing the expression of lncRNA JPX and regulating the Wnt/beta-catenin signaling pathway, suggesting a potential therapeutic strategy for OS.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biochemistry & Molecular Biology

LAMTOR5 expression level is a biomarker for colorectal cancer and lncRNA LAMTOR5-AS1 predicting miRNA sponging effect

Najmeh Riahi Zaniani et al.

Summary: The study suggests that the LAMTOR5 gene can be considered a prognostic biomarker for CRC. The nearby lncRNA LAMTOR5-AS5 could have a regulatory impact through its sponging effect on hsa-miR-let-7b-3p and hsa-miR-20a-5p, both of which show significant impacts on overall survival rate in CRC patients under high expression levels.

MOLECULAR BIOLOGY REPORTS (2021)

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Article Biochemistry & Molecular Biology

Structure of an inactive RNA polymerase II dimer

Shintaro Aibara et al.

Summary: The study presents the structure of a mammalian Pol II dimer, showing its distinct features from the Pol I dimer and suggesting that the Pol II dimer may represent an inactive storage form of the polymerase.

NUCLEIC ACIDS RESEARCH (2021)

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Article Multidisciplinary Sciences

LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling

Xudong Huang et al.

Summary: LINC00842 plays a role in promoting the malignancy of pancreatic ductal adenocarcinoma by regulating the acetylation status of PGC-1 alpha, leading to metabolic reprogramming in cancer cells.

NATURE COMMUNICATIONS (2021)

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Article Nutrition & Dietetics

Coffee Restores Expression of lncRNAs Involved in Steatosis and Fibrosis in a Mouse Model of NAFLD

Stefania Di Mauro et al.

Summary: The study found that decaffeinated coffee intake can reduce weight gain, prevent NAFLD, lower hyperglycemia, and hypercholesterolemia. The hepatoprotective effects of coffee may depend on the modulation of lncRNAs involved in key pathways of NAFLD onset and progression.

NUTRIENTS (2021)

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Article Medicine, Research & Experimental

Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model

Claudia Milazzo et al.

Summary: Research findings demonstrate that ASO-induced reactivation of UBE3A in AS mice can lead to positive effects on AS phenotypes, such as restored sensitivity to seizures and improvements in behavior, indicating therapeutic potential.

JCI INSIGHT (2021)

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Article Biochemistry & Molecular Biology

Differential Allelic Expression among Long Non-Coding RNAs

Michael B. Heskett et al.

Summary: Long non-coding RNAs (lncRNA) are a diverse group of non-protein-coding RNAs over 200 bp in length that can affect coding gene expression through mechanisms in cis or in trans. lncRNAs with differential allelic expression play critical roles in developmental gene regulation, chromosome structure, and disease.

NON-CODING RNA (2021)

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Review Endocrinology & Metabolism

Bone Aging, Cellular Senescence, and Osteoporosis

Robert J. Pignolo et al.

Summary: This study focuses on the physiological changes in aging bones and the role of cellular senescence in age-related osteoporosis. It reviews different aspects of bone aging, including remodeling deficits, uncoupling phenomena, and the accumulation of senescent cells in the bone microenvironment, as major mechanisms for age-related osteoporosis. The study also discusses the potential therapeutic interventions based on clearing senescent cells or suppressing the senescence-associated secretory phenotype.

JBMR PLUS (2021)

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Review Nanoscience & Nanotechnology

RNA Interference and Nanotechnology: A Promising Alliance for Next Generation Cancer Therapeutics

Guruprasadh Swaminathan et al.

Summary: Cancer is a major health risk in the 21st century, with predicted increasing incidence in the future. RNA interference (RNAi) based cancer therapeutics targeting deregulated molecules associated with tumorigenesis offers precise and potentially less toxic treatment options. Nanotechnology, with its enhanced permeation and tumor-targeting efficiency, provides promising solutions for effective medical utilization of bio-drugs in cancer therapy, particularly in combination with nanoparticles for nano-RNAi delivery strategies.

FRONTIERS IN NANOTECHNOLOGY (2021)

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Article Psychology, Mathematical

Visual statistical learning is modulated by arbitrary and natural categories

Leeland L. Rogers et al.

Summary: The study found that visual statistical learning is influenced by the learning goals of the observer and their prior knowledge about the structure of the world. Different categories of stimuli have an impact on learning effects, while natural categories also have an influence on learning outcomes.

PSYCHONOMIC BULLETIN & REVIEW (2021)

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Review Oncology

The role of long non-coding RNA H19 in breast cancer (Review)

Ji Wang et al.

ONCOLOGY LETTERS (2020)

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Article Biochemistry & Molecular Biology

Telomere-Specialized Retroelements in Drosophila: Adaptive Symbionts of the Genome, Neutral, or in Conflict?

Dragomira N. Markova et al.

BIOESSAYS (2020)

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Review Medicine, Research & Experimental

H19 lncRNA: Roles in tumorigenesis

Soudeh Ghafouri-Fard et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

lncRNA-H19/miR-29a axis affected the viability and apoptosis of keloid fibroblasts through acting upon COL1A1 signaling

Zhi Wang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging

Martina Rossi et al.

TRENDS IN MOLECULAR MEDICINE (2020)

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Article Endocrinology & Metabolism

Antisense oligonucleotide-based therapies for the treatment of osteoarthritis: Opportunities and roadblocks

Akihiro Nakamura et al.

BONE (2020)

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Review Biochemistry & Molecular Biology

Mitochondrial Epigenetics: Non-Coding RNAs as a Novel Layer of Complexity

Giovanna C. Cavalcante et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Oncology

MicroRNAs (miRNAs) and Long Non-Coding RNAs (lncRNAs) as New Tools for Cancer Therapy: First Steps from Bench to Bedside

Margherita Ratti et al.

TARGETED ONCOLOGY (2020)

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Article Cell Biology

Telomere transcription in ageing

Julio Aguado et al.

AGEING RESEARCH REVIEWS (2020)

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Review Immunology

The interplay between immunosenescence and age-related diseases

Florencia Barbe-Tuana et al.

SEMINARS IN IMMUNOPATHOLOGY (2020)

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Review Cell Biology

Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin

Michael J. Emanuele et al.

TRENDS IN CELL BIOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA 00507/miRNA-181c-5p/TTBK1/MAPT axis regulates tau hyperphosphorylation in Alzheimer's disease

Yan Yan et al.

JOURNAL OF GENE MEDICINE (2020)

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Article Pharmacology & Pharmacy

PI3K/AKT/mTOR pathway-related long non-coding RNAs: roles and mechanisms in hepatocellular carcinoma

Yuting Wu et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Oncology

HDAC9 Is Preferentially Expressed in Dedifferentiated Hepatocellular Carcinoma Cells and Is Involved in an Anchorage-Independent Growth

Keita Kanki et al.

CANCERS (2020)

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Review Biochemistry & Molecular Biology

Roles and Mechanisms of the Long Noncoding RNAs in Cervical Cancer

Miguel Angel Caceres-Duran et al.

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Random Formation of G-Quadruplexes in the Full-Length Human Telomere Overhangs Leads to a Kinetic Folding Pattern with Targetable Vacant G-Tracts

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Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases

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