Molecular hallmarks of long non-coding RNAs in aging and its significant effect on aging-associated diseases

Aging is linked to the deterioration of many physical and cognitive abilities and is the leading risk factor for Alzheimer's disease. The growing aging population is a significant healthcare problem globally that researchers must investigate to better understand the underlying aging processes. Advances in microarrays and sequencing techniques have resulted in deeper analyses of diverse essential genomes (e.g., mouse, human, and rat) and their corresponding cell types, their organ-specific transcriptomes, and the tissue involved in aging. Traditional gene controllers such as DNA- and RNA-binding proteins significantly influence such programs, causing the need to sort out long non-coding RNAs, a new class of powerful gene regulatory elements. However, their functional significance in the aging process and senescence has yet to be investigated and identified. Several recent researchers have associated the initiation and development of senescence and aging in mammals with several well-reported and novel long non-coding RNAs. In this review article, we identified and analyzed the evolving functions of long non-coding RNAs in cellular processes, including cellular senescence, aging, and age-related pathogenesis, which are the major hallmarks of long non-coding RNAs in aging.

Automated summary

Aging is associated with the deterioration of physical and cognitive abilities, and is a major risk factor for Alzheimer's disease. Investigating the underlying aging processes in the growing aging population is crucial for better understanding and addressing this global healthcare problem. Advances in microarrays and sequencing techniques have allowed for deeper analyses of diverse genomes and their involvement in aging, including the study of long non-coding RNAs as powerful gene regulatory elements. However, the functional significance of long non-coding RNAs in the aging process and senescence still needs to be investigated and identified.