Perspective on inflammatory cytokines in open spinal dysraphism

Article Surgery

Preliminary Results of a Reverse Thermal Gel Patch for Fetal Ovine Myelomeningocele Repair

James Bardill et al.

Summary: The study demonstrates the effectiveness of a novel RTG patch in promoting skin coverage and reducing inflammation in fetal sheep with MMC. The RTG patch also prevented spinal cord injury and brain abnormalities. Exciting results have been obtained for future comprehensive evaluation of the RTG patch.

JOURNAL OF SURGICAL RESEARCH (2022)

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Article Immunology

Acute IL-1RA treatment suppresses the peripheral and central inflammatory response to spinal cord injury

Abi G. Yates et al.

Summary: The study found that exogenous administration of IL-1RA can attenuate the acute phase response (APR) in traumatic spinal cord injury, reducing immune cell infiltration at the spinal cord lesion site.

JOURNAL OF NEUROINFLAMMATION (2021)

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Review Cell Biology

The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury

Edwin S. Kulubya et al.

Summary: Spinal cord injury is a devastating condition for which there is currently no reliable treatment. Mesenchymal stem/stromal cells have shown promise in treating SCI, with clinical trials using various adult tissue-derived MSC sources underway. The first stem/stromal cell clinical trial for spina bifida is also currently underway, utilizing placental-derived PMSCs for fetal repair. PMSCs have exhibited unique properties that make them promising for SCI therapy, including neuroprotective, angiogenic, and antioxidant capabilities.

CELLS (2021)

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Article Critical Care Medicine

Fetal and Perinatal Expression Profiles of Proinflammatory Cytokines in the Neuroplacodes of Rats with Myelomeningoceles: A Contribution to the Understanding of Secondary Spinal Cord Injury in Open Spinal Dysraphism

Gesa Cohrs et al.

Summary: This study investigated the cellular and molecular mechanisms underlying the functional decline in myelomeningocele (MMC) placodes using a retinoic acid-induced MMC rat model. The findings showed inflammatory cells and glial activation in later gestational stages, along with significant changes in cytokine expression levels at different embryonic stages. These results contribute to understanding the pathophysiological mechanisms and potential therapeutic targets for open spinal dysraphism.

JOURNAL OF NEUROTRAUMA (2021)

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Article Clinical Neurology

Comparison of Follow-Up Length-Matched Single-Center Myelomeningocele Postnatal Closure Cohort to the Management of Myelomeningocele Study (MOMS) Trial Results

Kristin J. Weaver et al.

Summary: This study compared the postnatal myelomeningocele closure cohort to the MOMS trial cohorts and found that overall ambulation and anatomic-functional level were significantly better in the postnatal cohort. However, ambulatory ability declined significantly with age in this patient population.

PEDIATRIC NEUROSURGERY (2021)

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Article Clinical Neurology