Journal
CELL
Volume 162, Issue 6, Pages 1206-1208Publisher
CELL PRESS
DOI: 10.1016/j.cell.2015.08.064
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Funding
- Intramural NIH HHS [Z01 BC010763-03] Funding Source: Medline
- Wellcome Trust [105663] Funding Source: Medline
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It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity.
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