4.5 Review

Systemic sclerosis gastrointestinal dysmotility: risk factors, pathophysiology, diagnosis and management

Related references

Note: Only part of the references are listed.
Article Rheumatology

Slow Colonic Transit in Systemic Sclerosis: An Objective Assessment of Risk Factors and Clinical Phenotype

Jenice X. Cheah et al.

Summary: This study aimed to identify specific clinical features associated with slow colonic transit in patients with systemic sclerosis (SSc). The study found that female sex, telangiectasia, anticentromere antibodies, smoking, and more severe gastrointestinal symptoms were positively associated with slow colonic transit. In the multivariable model, telangiectasia and less severe lung disease remained statistically significant in relation to slow colonic transit.

ARTHRITIS CARE & RESEARCH (2023)

Article Rheumatology

Use of vonoprazan, a novel potassium-competitive acid blocker, for the treatment of proton pump inhibitor-refractory reflux esophagitis in patients with systemic sclerosis

Yuichiro Shirai et al.

Summary: Vonoprazan showed significant efficacy in treating proton pump inhibitor-refractory reflux esophagitis in patients with systemic sclerosis, improving endoscopic findings, promoting mucosal healing, and alleviating symptoms effectively.

JOURNAL OF SCLERODERMA AND RELATED DISORDERS (2022)

Article Rheumatology

Relationship Between Gastrointestinal Transit, Medsger Gastrointestinal Severity, and University of California-Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 Symptoms in Patients With Systemic Sclerosis

Zsuzsanna H. McMahan et al.

Summary: The study found that abnormalities in gastrointestinal transit in SSc patients may contribute to increased gastrointestinal symptoms and severity, especially affecting the transit and emptying functions of the esophagus and colon.

ARTHRITIS CARE & RESEARCH (2022)

Article Otorhinolaryngology

Effects of Pyridostigmine on Esophageal and Pharyngeal Motility in Dysphagic Patients Undergoing High-Resolution Manometry

Shumon Dhar et al.

Summary: The results of this pilot study demonstrate that pyridostigmine acutely improves esophageal contractile vigor in patients suffering from dysphagia with esophageal dysmotility. Further investigation with larger sample size, longer follow-up, side effect profile, and patient-reported outcome measures is still needed to determine the clinical usefulness of pyridostigmine in specific disorders of esophageal motility.

DYSPHAGIA (2022)

Review Gastroenterology & Hepatology

AGA Clinical Practice Update on the Personalized Approach to the Evaluation and Management of GERD: Expert Review

Rena Yadlapati et al.

Summary: This review outlines a personalized diagnostic and therapeutic approach to GERD symptoms and provides detailed recommendations for clinical practice.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Review Gastroenterology & Hepatology

Gut feelings: mechanosensing in the gastrointestinal tract

Arnaldo Mercado-Perez et al.

Summary: Mechanosensation is crucial for normal gastrointestinal tract function and is often disrupted in gastrointestinal diseases. The gut contains various mechanosensory cells that can detect mechanical stimuli and coordinate physiological responses. Recent discoveries of mechanosensory molecules and understanding of related circuits have advanced our knowledge in this field.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

Article Rheumatology

Gastroparesis in systemic sclerosis: a detailed analysis using whole-gut scintigraphy

Brittany Adler et al.

Summary: This study aimed to investigate the overlap between gastroparesis and dysmotility in other areas of the gastrointestinal (GI) tract in SSc patients and its correlation with GI symptoms and SSc features. The findings suggest that gastric emptying of liquids along with solids may be a more sensitive and clinically relevant measure of gastroparesis in SSc. Additionally, SSc patients with gastroparesis often exhibit dysmotility in other areas of the GI tract, highlighting the need for whole-gut scintigraphy to evaluate the entire gut.

RHEUMATOLOGY (2022)

Article Gastroenterology & Hepatology

Effect of Domperidone Therapy on Gastroparesis Symptoms: Results of a Dynamic Cohort Study by NIDDK Gastroparesis Consortium

Irene Sarosiek et al.

Summary: This study aimed to evaluate the effectiveness of domperidone (DOM) in treating gastroparesis (GP) and found that DOM treatment can moderately but significantly improve the symptoms of GP.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Multidisciplinary Sciences

A multidimensional coding architecture of the vagal interoceptive system

Qiancheng Zhao et al.

Summary: This study reveals a multidimensional coding architecture of the mammalian vagal interoceptive system, in which VSNs code signals in different dimensions such as visceral organs, tissue layers, and stimulus modalities, enabling complex projections of VSNs in the brainstem.

NATURE (2022)

Article Biology

Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

Natasja Barki et al.

Summary: Volatile small molecules, including SCFAs, can act on the body in a hormone-like manner through specific GPCRs. FFA2 and FFA3 are the primary GPCR targets for SCFAs. They have distinct functions and regulate cellular activity and calcium levels through different mechanisms and signaling pathways in the gut and nervous system.

ELIFE (2022)

Article Anatomy & Morphology

Sympathetic innervation of the development, maturity, and aging of the gastrointestinal tract

Petr M. Masliukov et al.

Summary: This article provides an overview of the sympathetic innervation of the gastrointestinal tract, focusing on the prevertebral sympathetic ganglia as the main output to the gut. It also highlights the developmental processes of sympathetic innervation and the mechanisms controlling the development of sympathetic neurons.

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2022)

Editorial Material Rheumatology

Proton pump inhibitors in systemic sclerosis: a reappraisal to optimise treatment of gastro-oesophageal reflux disease

Michael Hughes et al.

Summary: Gastro-oesophageal reflux disease (GERD) is a significant morbidity for patients with systemic sclerosis. Although proton pump inhibitors (PPIs) are commonly used, there is limited evidence to support their empirical use in systemic sclerosis. This viewpoint highlights the beneficial impact of PPIs on GERD in systemic sclerosis while considering the safety concerns and unmet needs in this patient population.

LANCET RHEUMATOLOGY (2022)

Review Allergy

Enteric nervous system and intestinal epithelial regulation of the gut-brain axis

Laura R. Dowling et al.

Summary: The gut-brain axis refers to the bidirectional interaction between the intestinal environment, including the epithelium, immune system, microbiota, and the enteric nervous system. This interaction plays a crucial role in linking environmental stimuli and nervous system function, as well as providing feedback from the brain to intestinal activities. The gut microbiota has a profound influence on these processes, which has not been extensively studied. Disruption of the gut microbiota is associated with both gut diseases and brain symptoms such as neurodegenerative and behavioral disorders.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Review Gastroenterology & Hepatology

Nerves in gastrointestinal cancer: from mechanism to modulations

Nathalie Vaes et al.

Summary: Maintaining gastrointestinal health is challenging due to the complex and dynamic nature of the gastrointestinal tract. Disturbances in this environment can lead to gastrointestinal cancers, which account for a significant proportion of cancer cases and deaths worldwide. While the role of the tumor microenvironment has been extensively studied, the importance of the nervous system in gastrointestinal cancers has only recently been recognized. This article sheds light on the neural influences during gastrointestinal carcinogenesis, focusing on interactions between neurons and components of the gastrointestinal tract and tumor microenvironment, neural signaling pathways, and the impact on cancer hallmarks. Neural-related therapies for gastrointestinal cancer management are also discussed.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

Article Rheumatology

Gastric antral vascular ectasia in systemic sclerosis: a study of its epidemiology, disease characteristics and impact on survival

Kathleen Morrisroe et al.

Summary: This study describes the epidemiology, determinants, and survival impact of gastric antral vascular ectasia (GAVE) in systemic sclerosis (SSc). The study found that GAVE occurred relatively frequently in SSc patients, and was associated with age, disease subtype, antibody positivity, and patients' quality of life.

ARTHRITIS RESEARCH & THERAPY (2022)

Article Radiology, Nuclear Medicine & Medical Imaging

Experience with Esophagogastrointestinal Transit Scintigraphy in the Initial 229 Patients: Multiple Regions of Dysmotility Are Common

Harvey A. Ziessman et al.

Summary: This study found that most patients had dysmotility in different regions of the esophagogastrointestinal tract. There was a poor correlation between the results of the water-only study and water with the solid meal study. Patient symptoms were often not predictive of scintigraphic findings.

JOURNAL OF NUCLEAR MEDICINE (2021)

Review Gastroenterology & Hepatology

Neural control of gut homeostasis

Nasser Abdullah et al.

Summary: This study explores the neural control of gut homeostasis and the interactions between primary afferent nociceptors and various cell types within the gut wall, highlighting their roles in immune regulation, host response to pathogens, and modulation of visceral sensitivity. The gut-brain axis is crucial for maintaining gut homeostasis and influencing higher cognitive functions and emotions, with potential implications for neurological and behavioral disorders.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

Article Gastroenterology & Hepatology

Combinatorial Transcriptional Profiling of Mouse and Human Enteric Neurons Identifies Shared and Disparate Subtypes In Situ

Aaron A. May-Zhang et al.

Summary: The study compared human and mouse enteric neurons and found that several neuron subtypes in the duodenum, ileum, and colon are conserved between humans and mice. However, some subtype-specific genes from mice are expressed as completely distinct morphologically defined subtypes in humans.

GASTROENTEROLOGY (2021)

Review Gastroenterology & Hepatology

Brain-gut communication: vagovagal reflexes interconnect the two brains

Terry L. Powley

Summary: The gastrointestinal tract has its own brain, the enteric nervous system, which is linked to the central nervous system through the dorsal vagal complex. This brain-gut connectome provides reflex adjustments to optimize digestion and assimilation, helping to maintain internal balance and adapt to environmental situations. The plasticity and flexibility provided by the vagovagal circuitry may contribute to adaptive disorders in certain circumstances.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

Article Gastroenterology & Hepatology

Clinical Impact of Rectal Hyposensitivity: A Cross-Sectional Study of 2,876 Patients With Refractory Functional Constipation

Paul F. Vollebregt et al.

Summary: The study revealed that 25% of patients with refractory functional constipation have rectal hyposensitivity. There is a linear relationship between the number of elevated sensory thresholds and the severity of constipation, and RH is significantly associated with defecation symptoms and physiological investigations.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Article Gastroenterology & Hepatology

Prevalence of Barrett's Esophagus in Female Patients With Scleroderma

Diana L. Snyder et al.

Summary: This study is the largest on the prevalence of BE in women with SSc, revealing a prevalence of 12.8%. Women with SSc with BE were more likely to show features of a scleroderma esophagus on HRM. The high prevalence and incidence of dysplasia found suggest that women with SSc should be included in screening recommendations for BE.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Review Pharmacology & Pharmacy

Domperidone and the risks of sudden cardiac death and ventricular arrhythmia: A systematic review and meta-analysis of observational studies

Linda B. Ou et al.

Summary: The study examined the association of domperidone with sudden cardiac death and ventricular arrhythmia through a systematic review and meta-analysis of observational studies. The results showed that domperidone is associated with an increased risk of sudden cardiac death and ventricular arrhythmia compared to nonuse, indicating the need for further investigation with active comparator and in younger populations.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Review Rheumatology

Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis: a systematic review and meta-analysis

Xin Feng et al.

Summary: The prevalence of SIBO is high in SSc patients, and diarrhea may be a predictor. Antibiotic therapy is effective in treating SIBO in SSc patients.

CLINICAL RHEUMATOLOGY (2021)

Editorial Material Gastroenterology & Hepatology

Decoding the Enteric Nervous System: The Beginning of Our Understanding of Enteric Neuromuscular Disorders?

Subhash Kulkarni et al.

GASTROENTEROLOGY (2021)

Article Neurosciences

Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing

Khomgrit Morarach et al.

Summary: Utilizing single-cell RNA sequencing, researchers identified 12 enteric neuron classes in the myenteric plexus of the mouse small intestine, revealing a novel principle of neuronal diversification during development. They found that two neuron classes arise through a binary neurogenic branching, while all other identities emerge through subsequent postmitotic differentiation.

NATURE NEUROSCIENCE (2021)

Article Gastroenterology & Hepatology

Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0(C)

Rena Yadlapati et al.

Summary: CCv4.0 is an updated classification scheme for esophageal motility disorders using HRM, developed by fifty-two international experts in seven subgroups over two years. Key updates include a more rigorous and expansive HRM protocol, refined definition of EGJOO, stricter criteria for ineffective esophageal motility, and description of baseline EGJ metrics. These changes aim to provide more standardized criteria for disorders of peristalsis and obstruction at the EGJ.

NEUROGASTROENTEROLOGY AND MOTILITY (2021)

Article Gastroenterology & Hepatology

Scleroderma and the Esophagus

Nitin K. Ahuja et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2021)

Article Gastroenterology & Hepatology

Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity

Ying Zhu et al.

Summary: This study found that transcutaneous auricular vagal nerve stimulation has therapeutic potential for functional dyspepsia by improving gastric accommodation and slow waves through enhancing vagal efferent activity, leading to alleviation of dyspeptic symptoms, anxiety, and depression.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2021)

Review Rheumatology

A practical approach to the evaluation and management of gastrointestinal symptoms in patients with systemic sclerosis

Timothy Kaniecki et al.

Summary: Systemic sclerosis often affects the gastrointestinal tract, leading to impaired function and significant morbidity. This article consolidates current guidelines and proposes a symptom-based framework for diagnosis and management, while also identifying areas in need of further research.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2021)

Review Immunology

Neuro-innate immune interactions in gut mucosal immunity

Subhash Kulkarni et al.

Summary: This review discusses the key cellular players involved in neuro-immune interactions within the GI mucosa, with a focus on newly discovered neural pathways that regulate mucosal immunity in the context of GI health and disease.

CURRENT OPINION IN IMMUNOLOGY (2021)

Review Developmental Biology

Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force

Yi-Ning Kang et al.

Summary: This review focuses on the innervation of the gut during embryonic development, highlighting the importance of intrinsic and extrinsic nerves in ensuring proper gut function. The three-dimensional architecture of innervation and the differences in development along the longitudinal and circumferential axes of the gut are discussed. In addition, the formation of intrinsic and extrinsic innervation, as well as the potential influences of external microbial and nutritional cues or neuroimmune interactions on gut innervation development, are reviewed.

DEVELOPMENT (2021)

Review Multidisciplinary Sciences

Signaling inflammation across the gut-brain axis

Gulistan Agirman et al.

Summary: The brain and gastrointestinal tract, as critical sensory organs, interact through immune cells along the gut-brain axis to regulate inflammatory responses and immune balance, affecting the physiological state of the body.

SCIENCE (2021)

Article Genetics & Heredity

Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis

Damian R. Plichta et al.

Summary: The study analyzed the gut microbiomes of IgG4-RD and SSc patients, revealing distinct differences compared to healthy controls. There were significantly overabundant pathogenic bacteria and depleted beneficial bacteria in the patients, suggesting a potential role of gut microbiome in the pathophysiology of these diseases.

GENOME MEDICINE (2021)

Editorial Material Gastroenterology & Hepatology

Higher risk of neoplastic progression of Barrett's esophagus in patients with systemic sclerosis

Mythri Anilkumar et al.

GASTROENTEROLOGY REPORT (2021)

Article Gastroenterology & Hepatology

Integrative Effects and Vagal Mechanisms of Transcutaneous Electrical Acustimulation on Gastroesophageal Motility in Patients With Gastroesophageal Reflux Disease

Bo Zhang et al.

Summary: The study indicates that TEA treatment can significantly improve symptoms in patients with GERD, increase DCI, reduce ineffective esophageal contractions during wet swallows, and improve gastric accommodation and slow waves.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2021)

Article Cell Biology

Activation of KCNQ (KV7) K+ channels in enteric neurons inhibits epithelial Cl secretion in mouse distal colon

Andrew J. Nickerson et al.

Summary: The study showed that KV7 channel activators can inhibit Cl- secretion in the colonic epithelium, potentially providing therapeutic benefits for pathologies associated with hyperexcitable enteric nervous system.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)

Article Gastroenterology & Hepatology

Linaclotide for the treatment of refractory lower bowel manifestations of systemic sclerosis

Eric J. Dein et al.

Summary: Linaclotide is an effective and well-tolerated treatment option for managing refractory lower GI manifestations in SSc patients. Low-dose linaclotide may be better tolerated, but some patients may require high-dose regimens for effectiveness.

BMC GASTROENTEROLOGY (2021)

Review Biochemistry & Molecular Biology

The enteric nervous system in gastrointestinal disease etiology

Amy Marie Holland et al.

Summary: The enteric nervous system (ENS) plays a crucial role in regulating gastrointestinal function, and its dysfunction is closely linked to gastrointestinal diseases. Recent research indicates that the multifaceted connections between the ENS, intestinal epithelium, immune system, and gut microbiome are essential for maintaining gastrointestinal homeostasis. Therefore, the ENS plays a significant role in the pathogenesis of enteric neuropathies, inflammatory bowel diseases, and colorectal cancer.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Dentistry, Oral Surgery & Medicine

Measuring the impact of systemic sclerosis on oral health-related quality of life in a UK population

Ismail Abdouh et al.

Summary: The study found that systemic sclerosis negatively impacts the oral health-related quality of life and psychological well-being of affected individuals, with significantly higher scores in measures such as OIDP and MDAS among patients compared to controls.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2021)

Article Multidisciplinary Sciences

Capsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus

Matthew T. Henke et al.

Summary: Research has shown that some isolates of R. gnavus produce a capsular polysaccharide that promotes tolerogenic immune responses, while isolates lacking a capsule trigger robust proinflammatory responses. In mouse experiments, it was also found that mice colonized with an isolate of R. gnavus lacking a capsule showed increased gut inflammation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Neurosciences

Neurotrophin-4 is essential for survival of the majority of vagal afferents to the mucosa of the small intestine, but not the stomach

Hannah K. Serlin et al.

Summary: This study found that neurotrophin-4 (NT-4) is crucial for the survival of vagal afferents innervating the small intestine, but not those supplying the stomach. Interestingly, NT-4KO mice exhibited an increase in the density of central vagal afferent terminals, which may compensate for the loss of peripheral terminals in maintaining near-normal levels of satiety signaling.

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2021)

Article Multidisciplinary Sciences

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

Yuko Sato et al.

Summary: Centenarians have a unique gut microbiome enriched in microorganisms capable of producing specific bile acids, including a previously undescribed isoform. The specific bile acid isoalloLCA exhibits potent antimicrobial effects against Gram-positive multidrug-resistant pathogens, suggesting a potential role in reducing infection risk.

NATURE (2021)

Article Medicine, General & Internal

Safety and efficacy of faecal microbiota transplantation by Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis: study protocol for the randomised controlled phase II ReSScue trial

Anna-Maria Hoffmann-Vold et al.

Summary: This study aims to evaluate the safety and efficacy of fecal microbiota transplantation using Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis and gastrointestinal symptoms. The trial consists of three parts including an induction phase, maintenance phase, and extended monitoring period, with primary endpoint focused on changes in gastrointestinal symptoms such as diarrhea and bloating.

BMJ OPEN (2021)

Review Physiology

Regulation of the Autonomic Nervous System on Intestine

Hongyi Duan et al.

Summary: The intestine is composed of various types of cells that play important roles in digestion, absorption, neuroendocrine, and immune functions. The autonomic nervous system regulates cellular proliferation and function in the intestine. Understanding the distribution and function of the autonomic nervous system in the intestine could be helpful in treating intestinal diseases.

FRONTIERS IN PHYSIOLOGY (2021)

Article Rheumatology

Gastrointestinal involvement in systemic sclerosis: Effects on morbidity and mortality and new therapeutic approaches

Anna-Maria Hoffmann-Vold et al.

Summary: The majority of research studies on systemic sclerosis focus on skin and cardiopulmonary manifestations, with fewer studies addressing gastrointestinal tract involvement. This review provides an update on morbidity and mortality outcomes related to gastrointestinal involvement in systemic sclerosis, as well as conventional and emerging approaches to managing gastrointestinal symptoms. Recent developments in systemic sclerosis-gastrointestinal research have identified promising treatment targets, including specific auto-antibodies and microbiota alterations, and future research directions are discussed to improve understanding and alleviate suffering from this aspect of the disease.

JOURNAL OF SCLERODERMA AND RELATED DISORDERS (2021)

Article Gastroenterology & Hepatology

Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial

Pieter de Groot et al.

Summary: This study found that fecal microbiota transplantation can help delay disease progression and protect pancreatic function in patients with type 1 diabetes. Certain plasma metabolites and bacterial strains are associated with preserved residual beta cell function. The gut microbiome plays a crucial role in the pathophysiology of T1D.
Article Biochemistry & Molecular Biology

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

Abigail Jarret et al.

Correction Biochemistry & Molecular Biology

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity (vol 180, pg 50, 2020)

Abigail Jarret et al.

Article Gastroenterology & Hepatology

Open-label pilot study: Non-invasive vagal nerve stimulation improves symptoms and gastric emptying in patients with idiopathic gastroparesis

Andres Gottfried-Blackmore et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2020)

Review Biochemistry & Molecular Biology

Functional circuits and signal processing in the enteric nervous system

Candice Fung et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Review Gastroenterology & Hepatology

Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility

Nick J. Spencer et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Biochemistry & Molecular Biology

The Human and Mouse Enteric Nervous System at Single-Cell Resolution

Eugene Drokhlyansky et al.

Article Multidisciplinary Sciences

Microbiota modulate sympathetic neurons via a gut-brain circuit

Paul A. Muller et al.

NATURE (2020)

Article Neurosciences

Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo

Xueyuan Niu et al.

JOURNAL OF NEUROSCIENCE (2020)

Review Rheumatology

Gastrointestinal tract microbiota modifications in systemic sclerosis

Elizabeth R. Volkmann et al.

EUROPEAN JOURNAL OF RHEUMATOLOGY (2020)

Article Pharmacology & Pharmacy

Off-label use of aprepitant for scleroderma-associated nausea and vomiting: A case report

Bellal B. Jubran et al.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2019)

Article Rheumatology

Evaluation of risk factors for pseudo-obstruction in systemic sclerosis

Eric Dein et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2019)

Review Gastroenterology & Hepatology

Gastrointestinal Manifestations of Rheumatological Diseases

Paul T. Kroner et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2019)

Review Multidisciplinary Sciences

Vagal innervation of the stomach reassessed: brain-gut connectome uses smart terminals

Terry L. Powley et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2019)

Article Multidisciplinary Sciences

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide

Matthew T. Henke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Pharmacology & Pharmacy

Plecanatide for the treatment of chronic idiopathic constipation in adult patients

Gabrio Bassotti et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Loss of intestinal sympathetic innervation elicits an innate immune driven colitis

Rose A. Willemze et al.

MOLECULAR MEDICINE (2019)

Article Gastroenterology & Hepatology

Cannabinoid Use in Patients With Gastroparesis and Related Disorders: Prevalence and Benefit

Asad Jehangir et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2019)

Article Gastroenterology & Hepatology

Preventive effects of transcutaneous electrical acustimulation on ischemic stroke-induced constipation mediated via the autonomic pathway

Zhaoxiu Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

Article Gastroenterology & Hepatology

Modern diagnosis of GERD: the Lyon Consensus

C. Prakash Gyawali et al.

Article Rheumatology

Symptoms of Autonomic Dysfunction in Systemic Sclerosis Assessed by the COMPASS-31 Questionnaire

Brittany L. Adler et al.

JOURNAL OF RHEUMATOLOGY (2018)

Review Gastroenterology & Hepatology

Electroacupuncture treatments for gut motility disorders

J. D. Z. Chen et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2018)

Review Rheumatology

Pyridostigmine for the treatment of gastrointestinal symptoms in systemic sclerosis

Nitin K. Ahuja et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2018)

Article Neurosciences

Advances in Enteric Neurobiology: The Brain in the Gut in Health and Disease

Subhash Kulkarni et al.

JOURNAL OF NEUROSCIENCE (2018)

Review Gastroenterology & Hepatology

Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation

Satish S. C. Rao

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (2018)

Review Dentistry, Oral Surgery & Medicine

The spectrum of orofacial manifestations in systemic sclerosis: a challenging management

S. Jung et al.

ORAL DISEASES (2017)

Article Pharmacology & Pharmacy

Prucalopride for the treatment of ileus

Christopher J. Smart et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2017)

Article Medicine, General & Internal

Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence

N. Y. Lai et al.

JOURNAL OF INTERNAL MEDICINE (2017)

Article Gastroenterology & Hepatology

The effect of mirtazapine on gastric accommodation, gastric sensitivity to distention, and nutrient tolerance in healthy subjects

F. Carbone et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2017)

Article Multidisciplinary Sciences

Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis

Subhash Kulkarni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Chemistry, Medicinal

Mirtazapine for symptom control in refractory gastroparesis

Mark Malamood et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2017)

Review Gastroenterology & Hepatology

Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis

D. A. Leiman et al.

DISEASES OF THE ESOPHAGUS (2017)

Article Health Care Sciences & Services

Effect of Mirtazapine on Gastric Emptying in Patients with Cancer-associated Anorexia

N. Kumar et al.

INDIAN JOURNAL OF PALLIATIVE CARE (2017)

Article Gastroenterology & Hepatology

A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation

Philip B. Miner et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

Review Gastroenterology & Hepatology

Review article: pathogenesis and clinical manifestations of gastrointestinal involvement in systemic sclerosis

S. Kumar et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2017)

Review Gastroenterology & Hepatology

Ghrelin and motilin receptors as drug targets for gastrointestinal disorders

Gareth J. Sanger et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

Article Gastroenterology & Hepatology

Role of muscarinic-3 receptor antibody in systemic sclerosis: correlation with disease duration and effects of IVIG

Sumit Kumar et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

Article Pharmacology & Pharmacy

Epithelial propionyl- and butyrylcholine as novel regulators of colonic ion transport

Sarah Moreno et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Article Biochemistry & Molecular Biology

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Melanie Schirmer et al.

Article Gastroenterology & Hepatology

Domperidone to Treat Symptoms of Gastroparesis: Benefits and Side Effects from a Large Single-Center Cohort

Ron Schey et al.

DIGESTIVE DISEASES AND SCIENCES (2016)

Article Gastroenterology & Hepatology

The Impact of Pelvic Floor and Lower Gastrointestinal Symptoms on Quality of Life in Women With Systemic Sclerosis

Sarah B. Umar et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2016)

Review Gastroenterology & Hepatology

Diagnosis and management of chronic constipation in adults

Satish S. C. Rao et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

Article Gastroenterology & Hepatology

Sensory innervation of the guinea pig colon and rectum compared using retrograde tracing and immunohistochemistry

B. N. Chen et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2016)

Review Medicine, General & Internal

Patient considerations in the management of chronic constipation: focus on prucalopride

Andrea Shin

PATIENT PREFERENCE AND ADHERENCE (2016)

Review Gastroenterology & Hepatology

Emerging strategies for the treatment of gastroparesis

James Langworthy et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2016)

Article Biochemistry & Molecular Biology

Orofacial Manifestations and Temporomandibular Disorders of Systemic Scleroderma: An Observational Study

Vito Crincoli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Gastroenterology & Hepatology

Lack of effect of sacral nerve stimulation for incontinence in patients with systemic sclerosis

S. K. Butt et al.

COLORECTAL DISEASE (2015)

Article Gastroenterology & Hepatology

The stomach in health and disease

R. H. Hunt et al.

Article Radiology, Nuclear Medicine & Medical Imaging

Comprehensive Radionuclide Esophagogastrointestinal Transit Study: Methodology, Reference Values, and Initial Clinical Experience

Alexander J. Antoniou et al.

JOURNAL OF NUCLEAR MEDICINE (2015)

Article Rheumatology

Systemic Sclerosis Gastrointestinal Disease and Its Management

Genevieve Gyger et al.

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2015)

Article Dentistry, Oral Surgery & Medicine

The Canadian Systemic Sclerosis Oral Health Study IV: oral radiographic manifestations in systemic sclerosis compared with the general population

Marie Dagenais et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY (2015)

Editorial Material Gastroenterology & Hepatology

Buspirone, a new drug for the management of patients with ineffective esophageal motility?

Charlotte Scheerens et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2015)

Article Gastroenterology & Hepatology

The Chicago Classification of esophageal motility disorders, v3.0

P. J. Kahrilas et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2015)

Review Rheumatology

Gastric Antral Vascular Ectasia in Systemic Sclerosis: Current Concepts

Raphael Hernando Parrado et al.

INTERNATIONAL JOURNAL OF RHEUMATOLOGY (2015)

Article Gastroenterology & Hepatology

Development of the NIH Patient-Reported Outcomes Measurement Information System (PROMIS) Gastrointestinal Symptom Scales

Brennan M. R. Spiegel et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2014)

Article Biochemistry & Molecular Biology

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

Paul Andrew Muller et al.

Review Gastroenterology & Hepatology

Small intestinal bacterial overgrowth: what it is and what it is not

Eamonn M. M. Quigley

CURRENT OPINION IN GASTROENTEROLOGY (2014)

Review Pharmacology & Pharmacy

New pharmacological treatment options for chronic constipation

Maura Corsetti et al.

EXPERT OPINION ON PHARMACOTHERAPY (2014)

Review Gastroenterology & Hepatology

Extrinsic primary afferent signalling in the gut

Simon J. H. Brookes et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2013)

Article Rheumatology

Gastrointestinal motility disorder assessment in systemic sclerosis

Edoardo Savarino et al.

RHEUMATOLOGY (2013)

Review Rheumatology

Neurologic involvement in scleroderma: A systematic review

Tiago Nardi Amaral et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2013)

Review Rheumatology

Lactulose Breath Test to Assess Oro-cecal Transit Delay and Estimate Esophageal Dysmotility in Scleroderma Patients

Lorenzo Gemignani et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2013)

Review Pharmacology & Pharmacy

Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance

Amit H. Sachdev et al.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2013)

Editorial Material Gastroenterology & Hepatology

Prucalopride for chronic intestinal pseudo-obstruction

P. Oustamanolakis et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2012)

Article Gastroenterology & Hepatology

Fecal Incontinence in Systemic Sclerosis Is Secondary to Neuropathy

Nora M. Thoua et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2012)

Article Gastroenterology & Hepatology

Efficacy of Buspirone, a Fundus-Relaxing Drug, in Patients With Functional Dyspepsia

Jan Tack et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2012)

Article Gastroenterology & Hepatology

Effect of buspirone, a 5-HT1A receptor agonist, on esophageal motility in healthy volunteers

M. Di Stefano et al.

DISEASES OF THE ESOPHAGUS (2012)

Article Medicine, Research & Experimental

Gastric Neuromodulation With Enterra System for Nausea and Vomiting in Patients With Gastroparesis

Jieyun Yin et al.

NEUROMODULATION (2012)

Review Rheumatology

Malnutrition in systemic sclerosis

Elizabeth Harrison et al.

RHEUMATOLOGY (2012)

Article Gastroenterology & Hepatology

Biofeedback therapy for constipation in adults

Satish S. C. Rao

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2011)

Article Dentistry, Oral Surgery & Medicine

Oral health of Chinese people with systemic sclerosis

C. H. Chu et al.

CLINICAL ORAL INVESTIGATIONS (2011)

Article Gastroenterology & Hepatology

Esophageal dysmotility associated with systemic sclerosis: a high-resolution manometry study

S. Roman et al.

DISEASES OF THE ESOPHAGUS (2011)

Article Rheumatology

Internal anal sphincter atrophy in patients with systemic sclerosis

Nora M. Thoua et al.

RHEUMATOLOGY (2011)

Article Gastroenterology & Hepatology

Increased Incidence of Small Intestinal Bacterial Overgrowth During Proton Pump Inhibitor Therapy

Lucio Lombardo et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2010)

Article Gastroenterology & Hepatology

Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells

Jagmohan Singh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2009)

Article Gastroenterology & Hepatology

Gastric slow waves, gastrointestinal symptoms and peptides in systemic sclerosis patients

T. A. McNearney et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2009)

Article Rheumatology

Small intestinal bacterial overgrowth in systemic sclerosis

Isabelle Marie et al.

RHEUMATOLOGY (2009)

Article Gastroenterology & Hepatology

Influence of buspirone on gastric sensorimotor function in man

L. Van Oudenhove et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2008)

Article Gastroenterology & Hepatology

Small intestinal bacterial overgrowth in patients suffering from scleroderma: Clinical effectiveness of its eradication

Andrea Parodi et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2008)

Article Clinical Neurology

Pilot study of pyridostigmine in constipated patients with autonomic neuropathy

Adil E. Bharucha et al.

CLINICAL AUTONOMIC RESEARCH (2008)

Review Neurosciences

Innervation of the gastrointestinal tract: Patterns of aging

Robert J. Phillips et al.

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2007)

Review Gastroenterology & Hepatology

Domperidone: Review of pharmacology and clinical applications in gastroenterology

Savio C. Reddymasu et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2007)

Article Gastroenterology & Hepatology

Autoimmune gastrointestinal dysmotility treated successfully with pyridostigmine

Shabana F. Pasha et al.

GASTROENTEROLOGY (2006)

Review Gastroenterology & Hepatology

Use and abuse of hydrogen breath tests

M Simrén et al.

Article Dentistry, Oral Surgery & Medicine

Mandibular resorption in progressive systemic sclerosis: a report of three cases

A Auluck et al.

DENTOMAXILLOFACIAL RADIOLOGY (2005)

Review Rheumatology

Severe gastrointestinal involvement in systemic sclerosis: Report of five cases and review of the literature

K Jaovisidha et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2005)

Article Gastroenterology & Hepatology

Musings on the wanderer: What's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut

HY Chang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)

Article Surgery

Erythromycin enhances oesophageal motility in patients with gastro-oesophageal reflux

E Chrysos et al.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY (2001)