☆ 4.6 Review

The gut microbiota in obesity and weight management: microbes as friends or foe?

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Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised crossover trial

Edward S. Chambers et al.

GUT (2019)

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Article Nutrition & Dietetics

Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study

Claire S. Byrne et al.

NUTRIENTS (2019)

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Article Endocrinology & Metabolism

Akkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement

Maria Carlota Dao et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)

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Article Endocrinology & Metabolism

Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery

Jean Debedat et al.

CURRENT OBESITY REPORTS (2019)

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Article Multidisciplinary Sciences

Factors affecting the composition of the gut microbiota, and its modulation

Nihal Hasan et al.

PEERJ (2019)

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Review Nutrition & Dietetics

Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome-A Systematic Review

Zhengxiao Zhang et al.

NUTRIENTS (2019)

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Review Nutrition & Dietetics

Dietary fat, the gut microbiota, and metabolic health - A systematic review conducted within the MyNewGut project

Maike Wolters et al.

CLINICAL NUTRITION (2019)

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Review Medicine, General & Internal

Carbohydrate quality and human health: a series of systematic reviews and meta-analyses

Andrew Reynolds et al.

LANCET (2019)

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Review Medical Laboratory Technology

Bile acids and the metabolic syndrome

Emma Rose McGlone et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2019)

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Article Gastroenterology & Hepatology

Islamic fasting leads to an increased abundance of Akkermansia muciniphila and Bacteroides fragilis group: A preliminary study on intermittent fasting

Ceren Ozkul et al.

TURKISH JOURNAL OF GASTROENTEROLOGY (2019)

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Review Microbiology

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Allison Agus et al.

CELL HOST & MICROBE (2018)

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Article Microbiology

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Yogesh Bhattarai et al.

CELL HOST & MICROBE (2018)

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Review Microbiology

The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease

Kassem Makki et al.

CELL HOST & MICROBE (2018)

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Article Cell Biology

Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice

Sumei Hu et al.

CELL METABOLISM (2018)

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Article Microbiology

Reproducible protocols for metagenomic analysis of human faecal phageomes

Andrey N. Shkoporov et al.

MICROBIOME (2018)

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Article Cell Biology

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

Jane M. Natividad et al.

CELL METABOLISM (2018)

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Review Multidisciplinary Sciences

Mechanisms of weight loss and improved metabolism following bariatric surgery

Christopher M. Mulla et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2018)

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Article Endocrinology & Metabolism

Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid-Producing Microbiota in the Gut

Jacobo de la Cuesta-Zuluaga et al.

DIABETES CARE (2017)

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Article Gastroenterology & Hepatology

Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism

Thibaut Duparc et al.

GUT (2017)

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Article Multidisciplinary Sciences

Commensal bacteria make GPCR ligands that mimic human signalling molecules

Louis J. Cohen et al.

NATURE (2017)

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Article Biochemistry & Molecular Biology

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

Hao Wu et al.

NATURE MEDICINE (2017)

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Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Glenn R. Gibson et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Nutrition & Dietetics

Effects of acute dietary weight loss on postprandial plasma bile acid responses in obese insulin resistant subjects

F. Samuel van Nierop et al.

CLINICAL NUTRITION (2017)

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Review Endocrinology & Metabolism

Innovation in microbiome-based strategies for promoting metabolic health

Marina Romani-Perez et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2017)

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Article Nutrition & Dietetics

Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans

Martin Beaumont et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2017)

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Review Cell Biology

Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics

Patrycja Puchalska et al.

CELL METABOLISM (2017)

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Article Cell Biology

Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints

Andrew J. Holmes et al.

CELL METABOLISM (2017)

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Article Gastroenterology & Hepatology

High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome

Francesca De Filippis et al.

GUT (2016)

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Review Endocrinology & Metabolism

Endocannabinoids - at the crossroads between the gut microbiota and host metabolism

Patrice D. Cani et al.

NATURE REVIEWS ENDOCRINOLOGY (2016)

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Article Multidisciplinary Sciences

Persistent microbiome alterations modulate the rate of post-dieting weight regain

Christoph A. Thaiss et al.

NATURE (2016)

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Article Biotechnology & Applied Microbiology

Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

Shanthadevi Udayappan et al.

NPJ BIOFILMS AND MICROBIOMES (2016)

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Article Multidisciplinary Sciences

Structural modulation of the gut microbiota and the relationship with body weight: compared evaluation of liraglutide and saxagliptin treatment

Lin Wang et al.

SCIENTIFIC REPORTS (2016)

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Review Gastroenterology & Hepatology

Consequences of bile salt biotransformations by intestinal bacteria

Jason M. Ridlon et al.

GUT MICROBES (2016)

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Meeting Abstract Gastroenterology & Hepatology

Body Mass Index Changes Aft er Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection

George Saffouri et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2016)

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Article Biochemistry & Molecular Biology

Personalized Nutrition by Prediction of Glycemic Responses

David Zeevi et al.

CELL (2015)

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Article Cell Biology

Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty InduceLong-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

Valentina Tremaroli et al.

CELL METABOLISM (2015)

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Article Cell Biology

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

Robert Caesar et al.

CELL METABOLISM (2015)

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Review Endocrinology & Metabolism

Short-chain fatty acids in control of body weight and insulin sensitivity

Emanuel E. Canfora et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

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Review Cardiac & Cardiovascular Systems

How the Seven Countries Study contributed to the definition and development of the Mediterranean diet concept: A 50-year journey

A. Menotti et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2015)

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Article Multidisciplinary Sciences

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

Lucie Geurts et al.

NATURE COMMUNICATIONS (2015)

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Article Gastroenterology & Hepatology

A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice

Fernando F. Anhe et al.

GUT (2015)

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Article Gastroenterology & Hepatology

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

Edward S. Chambers et al.

GUT (2015)

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Article Endocrinology & Metabolism

Long-term ketogenic diet causes glucose intolerance and reduced β- and α-cell mass but no weight loss in mice

Johanne H. Ellenbroek et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)

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Article Biochemistry & Molecular Biology

Human Genetics Shape the Gut Microbiome

Julia K. Goodrich et al.

CELL (2014)

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Article Biochemistry & Molecular Biology

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences

Laura M. Cox et al.

CELL (2014)

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Article Cell Biology

Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells

Catalin Chimerel et al.

CELL REPORTS (2014)

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Review Cell Biology

Pleiotropic Roles of Bile Acids in Metabolism

Thomas Q. de Aguiar Vallim et al.

CELL METABOLISM (2013)

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Article Gastroenterology & Hepatology

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

Evelyne M. Dewulf et al.

GUT (2013)

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Article Immunology

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

Teresa Zelante et al.

IMMUNITY (2013)

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Article Nutrition & Dietetics

Consumption of a low-carbohydrate and high-fat diet (the ketogenic diet) exaggerates biotin deficiency in mice

Masahiro Yuasa et al.

NUTRITION (2013)

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Article Multidisciplinary Sciences

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Vanessa K. Ridaura et al.

SCIENCE (2013)

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Article Endocrinology & Metabolism

Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice

B. M. Carvalho et al.

DIABETOLOGIA (2012)

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Article Gastroenterology & Hepatology

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

Anne Vrieze et al.

GASTROENTEROLOGY (2012)

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Article Multidisciplinary Sciences

Antibiotics in early life alter the murine colonic microbiome and adiposity

Ilseung Cho et al.

NATURE (2012)

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Article Health Care Sciences & Services

Life in a Germ-Free World: Isolating Life from the Laboratory Animal to the Bubble Boy

Robert G. W. Kirk

BULLETIN OF THE HISTORY OF MEDICINE (2012)

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Review Biochemistry & Molecular Biology

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

Chibueze A. Ihunnah et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

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Article Endocrinology & Metabolism

Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice

Amandine Everard et al.

DIABETES (2011)

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Article Gastroenterology & Hepatology

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

E. F. Murphy et al.

GUT (2010)

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Article Biochemistry & Molecular Biology

The endocannabinoid system links gut microbiota to adipogenesis

Giulio G. Muccioli et al.

MOLECULAR SYSTEMS BIOLOGY (2010)

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Article Multidisciplinary Sciences

High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse

Shengli Ding et al.

PLOS ONE (2010)

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Article Gastroenterology & Hepatology

High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity

Marie A. Hildebrandt et al.

GASTROENTEROLOGY (2009)

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Article Gastroenterology & Hepatology

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

P. D. Cani et al.

GUT (2009)

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Article Multidisciplinary Sciences

A core gut microbiome in obese and lean twins

Peter J. Turnbaugh et al.

NATURE (2009)

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Article Cell Biology

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

Peter J. Turnbaugh et al.

SCIENCE TRANSLATIONAL MEDICINE (2009)

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Article Endocrinology & Metabolism

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Patrice D. Cani et al.

DIABETES (2008)

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Article Endocrinology & Metabolism

Human colonic microbiota associated with diet, obesity and weight loss

S. H. Duncan et al.

INTERNATIONAL JOURNAL OF OBESITY (2008)

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Article Multidisciplinary Sciences

Predominant Role of Host Genetics in Controlling the Composition of Gut Microbiota

Zaruhi A. Khachatryan et al.

PLOS ONE (2008)

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Article Medicine, General & Internal

Adherence to Mediterranean diet and health status: meta-analysis

Francesco Sofi et al.

BMJ-BRITISH MEDICAL JOURNAL (2008)

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Article Endocrinology & Metabolism

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia

P. D. Cani et al.

DIABETOLOGIA (2007)

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Review Nutrition & Dietetics

Weight-loss outcomes: A systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up

Marion J. Franz et al.

JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION (2007)

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Article Endocrinology & Metabolism

Metabolic endotoxemia initiates obesity and insulin resistance

Patrice D. Cani et al.

DIABETES (2007)

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Article Multidisciplinary Sciences

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

Fredrik Backhed et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Multidisciplinary Sciences

Microbial ecology - Human gut microbes associated with obesity

Ruth E. Ley et al.

NATURE (2006)

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Article Multidisciplinary Sciences

An obesity-associated gut microbiome with increased capacity for energy harvest

Peter J. Turnbaugh et al.

NATURE (2006)

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Article Endocrinology & Metabolism

Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor

PD Cani et al.

DIABETES (2006)

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Review Biochemistry & Molecular Biology

Bile salt biotransformations by human intestinal bacteria

JM Ridlon et al.

JOURNAL OF LIPID RESEARCH (2006)

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Article Multidisciplinary Sciences

Obesity alters gut microbial ecology

RE Ley et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Gastroenterology & Hepatology

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice

M Wagner et al.

HEPATOLOGY (2005)

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Article Endocrinology & Metabolism

Oligofructose promotes satiety in rats fed a high-fat diet: Involvement of glucagon-like peptide-1

PD Cani et al.

OBESITY RESEARCH (2005)

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Article Nutrition & Dietetics

Impact of inulin and oligofructose on gastrointestinal peptides

NM Delzenne et al.

BRITISH JOURNAL OF NUTRITION (2005)

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Article Multidisciplinary Sciences

The gut microbiota as an environmental factor that regulates fat storage

F Bäckhed et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Biochemistry & Molecular Biology

Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

E Le Poul et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

NE Nilsson et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

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Article Biochemistry & Molecular Biology

The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

AJ Brown et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

A G protein-coupled receptor responsive to bile acids

Y Kawamata et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Multidisciplinary Sciences

Vitamin D receptor as an intestinal bile acid sensor

M Makishima et al.

SCIENCE (2002)

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Article Nutrition & Dietetics

Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa/fa rats

C Daubioul et al.

JOURNAL OF NUTRITION (2002)

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Article Nutrition & Dietetics

Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese Zucker rats

CA Daubioul et al.

JOURNAL OF NUTRITION (2000)

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Editorial Material Endocrinology & Metabolism

Do diet and microbes really 'PREDICT' cardiometabolic risks?

Patrice D. Cani et al.

Summary: The study finds correlations supporting the connection between dietary habits, cardiometabolic disorders, and the composition of gut microbiota. Further research is needed to determine if screening of fecal microorganisms can truly predict health.

NATURE REVIEWS ENDOCRINOLOGY

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