☆ 4.6 Review

The emerging roles of γδ T cells in cancer immunotherapy

NATURE REVIEWS CLINICAL ONCOLOGY (2023)

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BONE MARROW TRANSPLANTATION (2013)

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Review Immunology

Defining the nature of human gamma delta T cells: a biographical sketch of the highly empathetic

Shirin Kalyan et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2013)

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Article Immunology

NKG2D regulates production of soluble TRAIL by ex vivo expanded human γδ T cells

Pouneh Dokouhaki et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

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Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

Adrienne M. Luoma et al.

IMMUNITY (2013)

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Article Immunology

γδ T Cells Exhibit Multifunctional and Protective Memory in Intestinal Tissues

Brian S. Sheridan et al.

IMMUNITY (2013)

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Cutting Edge: CD1d Restriction and Th1/Th2/Th17 Cytokine Secretion by Human Vδ3 T Cells

Bozgana A. Mangan et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Immunology

Tumor-Derived γδ Regulatory T Cells Suppress Innate and Adaptive Immunity through the Induction of Immunosenescence

Jian Ye et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Biotechnology & Applied Microbiology

Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor

Drew C. Deniger et al.

MOLECULAR THERAPY (2013)

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Article Immunology

CD1d-lipid antigen recognition by the γδ TCR

Adam P. Uldrich et al.

NATURE IMMUNOLOGY (2013)

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Persistent Changes in Circulating and Intestinal γδ T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease

Margaret R. Dunne et al.

PLOS ONE (2013)

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Article Oncology

Human Vδ2 versus non-Vδ2 γδ T cells in antitumor immunity

Dieter Kabelitz et al.

ONCOIMMUNOLOGY (2013)

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Review Immunology

Six-of-the-best: unique contributions of γδ T cells to immunology

Pierre Vantourout et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Article Hematology

Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset

Christelle Harly et al.

BLOOD (2012)

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Activated human γδ T cells induce peptide-specific CD8+ T-cell responses to tumor-associated self-antigens

Bianca Altvater et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)

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Article Cell & Tissue Engineering

Human Vdelta1 gamma-delta T cells exert potent specific cytotoxicity against primary multiple myeloma cells

Andrea Knight et al.

CYTOTHERAPY (2012)

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IL-21 enhances the potential of human γδ T cells to provide B-cell help

Raj R. Bansal et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2012)

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Human γδ T Lymphocytes Are Licensed for Professional Antigen Presentation by Interaction with Opsonized Target Cells

Nourredine Himoudi et al.

JOURNAL OF IMMUNOLOGY (2012)

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Article Immunology

Tumor-Infiltrating γδ T Lymphocytes Predict Clinical Outcome in Human Breast Cancer

Chunling Ma et al.

JOURNAL OF IMMUNOLOGY (2012)

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Article Hematology

Redirecting αβT cells against cancer cells by transfer of a broadly tumor-reactive γδT-cell receptor

Victoria Marcu-Malina et al.

BLOOD (2011)

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Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells

Daniel V. Correia et al.

BLOOD (2011)

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Phase I/II study of adoptive transfer of γδ T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma

Hirohito Kobayashi et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2011)

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High Phosphoantigen Levels in Bisphosphonate-Treated Human Breast Tumors Promote Vγ9Vδ2 T-Cell Chemotaxis and Cytotoxicity In Vivo

Ismahene Benzaid et al.

CANCER RESEARCH (2011)

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Regulatory Role of Vγ1 γδ T Cells in Tumor Immunity through IL-4 Production

Jianlei Hao et al.

JOURNAL OF IMMUNOLOGY (2011)

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Stimulated γδ T Cells Increase the In Vivo Efficacy of Trastuzumab in HER-2+ Breast Cancer

Aude-Helene Capietto et al.

JOURNAL OF IMMUNOLOGY (2011)

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Article Cell Biology

Deep Sequencing of the Human TCRγ and TCRβ Repertoires Suggests that TCRβ Rearranges After ab and γδ T Cell Commitment

Anna M. Sherwood et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

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Human γδ T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement

Amudhan Maniar et al.

BLOOD (2010)

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Tumor-infiltrating IL-17-producing γδ T cells support the progression of tumor by promoting angiogenesis

Daiko Wakita et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2010)

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Vγ9Vγ2 T Lymphocytes Efficiently Recognize and Kill Zoledronate-Sensitized, Imatinib-Sensitive, and Imatinib-Resistant Chronic Myelogenous Leukemia Cells

Matilde D'Asaro et al.

JOURNAL OF IMMUNOLOGY (2010)

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V gamma 2V delta 2 T Cell Receptor Recognition of Prenyl Pyrophosphates Is Dependent on All CDRs

Hong Wang et al.

JOURNAL OF IMMUNOLOGY (2010)

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Triple-Negative Breast Cancer

William D. Foulkes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

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Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies

Julie Gertner-Dardenne et al.

BLOOD (2009)

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DNAX accessory molecule-1 (CD226) promotes human hepatocellular carcinoma cell lysis by Vγ9Vδ2 T cells

Olivier Toutirais et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

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Efficient Killing of Human Colon Cancer Stem Cells by gamma delta T Lymphocytes

Matilde Todaro et al.

JOURNAL OF IMMUNOLOGY (2009)

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Cross-presenting human γδ T cells induce robust CD8+ αβ T cell responses

Marlene Brandes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Long-term expansion of effector/memory Vδ2- γδ T cells is a specific blood signature of CMV infection

Vincent Pitard et al.

BLOOD (2008)

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Isopentenyl pyrophosphate-activated CD516+ γδ T lymphocytes display potent antitumor activity toward human squamous cell carcinoma

Alan A. Z. Alexander et al.

CLINICAL CANCER RESEARCH (2008)

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V gamma 9V delta 2 T cell cytotoxicity against tumor cells is enhanced by monoclonal antibody drugs - Rituximab and trastuzumab

Hirotake Tokuyama et al.

INTERNATIONAL JOURNAL OF CANCER (2008)

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Protective immunosurveillance and therapeutic antitumor activity of γδ T cells demonstrated in a mouse model of prostate cancer

Zhiyong Liu et al.

JOURNAL OF IMMUNOLOGY (2008)

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In vitro expansion of gamma delta T cells with anti-myeloma cell activity by Phosphostim and IL-2 in patients with multiple myeloma

Maka Burjanadze et al.

BRITISH JOURNAL OF HAEMATOLOGY (2007)

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Lysis of a broad range of epithelial tumour cells by human γδ T cells:: Involvement of NK62D ligands and T-cell receptor- versus NKG2D-dependent recognition

P. Wrobel et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2007)

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Tumor-infiltrating γδ T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway

Guangyong Peng et al.

IMMUNITY (2007)

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Chemotherapy and zoledronate sensitize solid tumour cells to Vγ9Vδ2 T cell cytotoxicity

Stephen R. Mattarollo et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2007)

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Targeting human γδ T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer

Francesco Dieli et al.

CANCER RESEARCH (2007)

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Skewed T cell receptor repertoire of Vδ1+ γδ T lymphocytes after human allogeneic haematopoietic stem cell transplantation and the potential role for Epstein-Barr virus-infected B cells in clonal restriction

N. Fujishima et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2007)

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Synthesis of pyrophosphate-containing compounds that stimulate V gamma 2V delta 2 T cells: Application to cancer immunotherapy

Y. Tanaka et al.

MEDICINAL CHEMISTRY (2007)

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CXCR5 identifies a subset of Vγ9Vδ2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production

Nadia Caccamo et al.

JOURNAL OF IMMUNOLOGY (2006)

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Activation of Vγ9Vδ2 T cells by NKG2D

B Rincon-Orozco et al.

JOURNAL OF IMMUNOLOGY (2005)

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Professional antigen-presentation function by human γδ T cells

M Brandes et al.

SCIENCE (2005)

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Phosphostim-activated γδ T cells kill autologous metastatic renal cell carcinoma

E Viey et al.

JOURNAL OF IMMUNOLOGY (2005)

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Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and γδ T cells

SEA Street et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

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Distinct subpopulations of γδ T cells are present in normal and tumor-bearing human liver

T Kenna et al.

CLINICAL IMMUNOLOGY (2004)

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FcγRIII discriminates between 2 subsets of Vγ9Vδ2 effector cells with different responses and activation pathways

DF Angelini et al.

BLOOD (2004)

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Human γδ T cells as mediators of chimaeric-receptor redirected anti-tumour immunity

M Rischer et al.

BRITISH JOURNAL OF HAEMATOLOGY (2004)

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Vδ1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid

A Poggi et al.

CANCER RESEARCH (2004)

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γδ T cells provide an early source of interferon γ in tumor immunity

YF Gao et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

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γδ T cells for immune therapy of patients with lymphoid malignancies

M Wilhelm et al.

BLOOD (2003)

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Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells

HJ Gober et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

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Review Immunology

γδ T cells:: Functional plasticity and heterogeneity

SR Carding et al.

NATURE REVIEWS IMMUNOLOGY (2002)

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Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human γδ T cells in Escherichia coli

M Hintz et al.

FEBS LETTERS (2001)

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Regulation of cutaneous malignancy by γδ T cells

M Girardi et al.

SCIENCE (2001)

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Human γδ T cells express a higher TCR/CD3 complex density than αβ T cells

L Nicolas et al.

CLINICAL IMMUNOLOGY (2001)

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The TCR δ repertoire in normal human skin is restricted and distinct from the TCR δ repertoire in the peripheral blood

V Holtmeier et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2001)

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Expression of toll-like receptor 2 on γδ T cells bearing invariant Vγ6/Vδ1 induced by Escherichia coli infection in mice

Y Mokuno et al.

JOURNAL OF IMMUNOLOGY (2000)

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Self-recognition of CD1 by γ/δ T cells:: Implications for innate immunity

FM Spada et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)

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