Related references
Note: Only part of the references are listed.Longer CAG repeat length is associated with shorter survival after disease onset in disease
Douglas R. Langbehn
AMERICAN JOURNAL OF HUMAN GENETICS (2022)
Antisense Oligonucleotide Therapy: From Design to the Huntington Disease Clinic
Morgan E. Rook et al.
BIODRUGS (2022)
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1
Ranjan Batra et al.
NATURE BIOMEDICAL ENGINEERING (2021)
PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API
Huaiyu Mi et al.
NUCLEIC ACIDS RESEARCH (2021)
Double setback for ASO trials in Huntington disease
Katie Kingwell
NATURE REVIEWS DRUG DISCOVERY (2021)
Hunting in silencing delays onset and slows progression of Huntington's disease: a biomarker study
Hongshuai Liu et al.
BRAIN (2021)
The emerging role of RNA modifications in the regulation of mRNA stability
Sung Ho Boo et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2020)
Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation
Charlene Smith-Geater et al.
STEM CELL REPORTS (2020)
Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities
Sarah J. Tabrizi et al.
NATURE REVIEWS NEUROLOGY (2020)
ComBat-seq: batch effect adjustment for RNA-seq count data
Yuqing Zhang et al.
NAR GENOMICS AND BIOINFORMATICS (2020)
Mitochondrial Dysfunction in Huntington's Disease; Interplay Between HSF1, p53 and PGC-1α Transcription Factors
Taylor A. Intihar et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease (vol 101, pg 801, 2019)
Sarah J. Tabrizi et al.
NEURON (2019)
Allele-selective transcriptional repression of mutant HTT for the treatment of Huntington's disease
Bryan Zeitler et al.
NATURE MEDICINE (2019)
Huntington's disease: a clinical review
P. McColgan et al.
EUROPEAN JOURNAL OF NEUROLOGY (2018)
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
Silvana Konermann et al.
CELL (2018)
Cause or compensation?Altered neuronal Ca2+ handling in Huntington's disease
James P. Mackay et al.
CNS NEUROSCIENCE & THERAPEUTICS (2018)
Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein
Winston X. Yan et al.
MOLECULAR CELL (2018)
Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d
Cheng Zhang et al.
CELL (2018)
New directions in therapeutics for Huntington disease
Katya T. Potkin et al.
FUTURE NEUROLOGY (2018)
Therapies targeting DNA and RNA in Huntington's disease (vol 16, pg 837, 2017)
E. J. Wild et al.
LANCET NEUROLOGY (2017)
Therapies targeting DNA and RNA in Huntington's disease
Edward J. Wild et al.
LANCET NEUROLOGY (2017)
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9
Ranjan Batra et al.
CELL (2017)
Is Huntingtin Dispensable in the Adult Brain?
Jeh-Ping Liu et al.
JOURNAL OF HUNTINGTONS DISEASE (2017)
Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice
Peter Langfelder et al.
NATURE NEUROSCIENCE (2016)
Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's Disease
Qi Peng et al.
PLOS ONE (2016)
Evaluating the SERCA2 and VEGF mRNAs as Potential Molecular Biomarkers of the Onset and Progression in Huntington's Disease
Federica Cesca et al.
PLOS ONE (2015)
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Yang Liao et al.
BIOINFORMATICS (2014)
A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease
Cendrine Tourette et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits
Spencer U. McKinstry et al.
JOURNAL OF NEUROSCIENCE (2014)
Huntington disease: natural history, biomarkers and prospects for therapeutics
Christopher A. Ross et al.
NATURE REVIEWS NEUROLOGY (2014)
Targeting autophagy in neurodegenerative diseases
Rene L. Vidal et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice
Soledad Galli et al.
NATURE COMMUNICATIONS (2014)
STAR: ultrafast universal RNA-seq aligner
Alexander Dobin et al.
BIOINFORMATICS (2013)
Mechanisms of RNA-induced toxicity in CAG repeat disorders
R. Nalavade et al.
CELL DEATH & DISEASE (2013)
Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum
Richard Grondin et al.
BRAIN (2012)
Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression
Dongbo Yu et al.
CELL (2012)
Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes
CELL STEM CELL (2012)
The incidence and prevalence of Huntington's disease: A systematic review and meta-analysis
Tamara Pringsheim et al.
MOVEMENT DISORDERS (2012)
Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice
Mireia Garriga-Canut et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity
Monica Banez-Coronel et al.
PLOS GENETICS (2012)
Huntington's disease: from molecular pathogenesis to clinical treatment
Christopher A. Ross et al.
LANCET NEUROLOGY (2011)
Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model
Yong Cheng et al.
NEUROIMAGE (2011)
Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference
Mateusz de Mezer et al.
NUCLEIC ACIDS RESEARCH (2011)
CAG-Repeat Length and the Age of Onset in Huntington Disease (HD): A Review and Validation Study of Statistical Approaches
Douglas R. Langbehn et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2010)
Allele-Selective Inhibition of Mutant Huntingtin Expression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat
Keith T. Gagnon et al.
BIOCHEMISTRY (2010)
The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus
Edoardo Marcora et al.
HUMAN MOLECULAR GENETICS (2010)
Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images
Jiangyang Zhang et al.
NEUROIMAGE (2010)
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin
Gerardo A. Morfini et al.
NATURE NEUROSCIENCE (2009)
Huntingtin as an essential integrator of intracellular vesicular trafficking
Juliane P. Caviston et al.
TRENDS IN CELL BIOLOGY (2009)
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs
Yuan Yuan et al.
NUCLEIC ACIDS RESEARCH (2007)
Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space
Anne N. T. Strehlow et al.
HUMAN MOLECULAR GENETICS (2007)
CAG repeats containing CAA interruptions form branched hairpin structures in spinocerebellar ataxia type 2 transcripts
K Sobczak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
LR Gauthier et al.
CELL (2004)
Imperfect CAG repeats form diverse structures in SCA1 transcripts
K Sobczak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
RNA structure of trinucleotide repeats associated with human neurological diseases
K Sobczak et al.
NUCLEIC ACIDS RESEARCH (2003)
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
C Zuccato et al.
NATURE GENETICS (2003)
Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription
KB Kegel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Triplet repeats, RNA secondary structure and toxic gain-of-function models for pathogenesis
R Galvao et al.
BRAIN RESEARCH BULLETIN (2001)