Peptides hit the catalysis walk

A protein-protein interface between a peptide-recognition domain (Fyn-SH3) and catechol O-methyltransferase (COMT) is computationally designed to generate a highly selective peptide-modifying system. Detailed mechanistic analysis sets a gold standard for studying the complex kinetic properties of designer fusion proteins.

Automated summary

A highly selective peptide-modifying system is computationally designed through a protein-protein interface, which sets a gold standard for studying the complex kinetic properties of designer fusion proteins.