Nuclear condensates in YAP1-driven ependymoma

An ependymoma subtype is driven by fusion proteins related to the transcriptional regulator YAP1. Research now shows that localization of these fusion proteins within nuclear condensates is necessary and sufficient for tumour formation through the activation of various genetic and epigenetic oncogenic mechanisms.

Automated summary

An ependymoma subtype is caused by fusion proteins associated with YAP1, which are localized within nuclear condensates and play a crucial role in tumor formation by activating various oncogenic mechanisms.