Journal
NATURAL PRODUCT RESEARCH
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2153362
Keywords
Xylaria sp; endophytic fungus; cytochalasins; antibacterial activities
Categories
Funding
- National Natural Science Foundation of China
- Guangxi Natural Science Foundation of China
- Project of State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University)
- [21762007]
- [2018GXNSFAA281169]
- [CMEMR2016-A06]
- [CMEMR2018-C29]
- [CMEMR2019-A1]
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Two new open-chain cytochalasins and six known analogues were isolated from a Chinese medicinal plant Sophora tonkinensis. One of the new compounds showed moderate antibacterial activities against Bacillus subtilis and Escherichia coli.
Two new open-chain cytochalasins, xylarchalasins A and B (1 and 2), together with six known analogues (3-8), were isolated from the endophytic fungus Xylaria sp. GDGJ-77B from the Chinese medicinal plant Sophora tonkinensis. Their structures were elucidated on the basis of comprehensive spectroscopic analysis. Compound 2 displayed moderate antibacterial activities against Bacillus subtilis and Escherichia coli with MIC values of 25 and 12.5 mu g/mL, respectively.
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