Journal
NATURAL PRODUCT RESEARCH
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2152022
Keywords
Delphinium pachycentrum Hemsl; Ranunculaceae; diterpenoid alkaloid; pachycentine; anti-inflammatory
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Funding
- National Natural Science Foundation of China
- Chinese Medicine, Ethnic Medicine Science and Technology Research Project of Guizhou Provincial Administration of Traditional Chinese Medicine
- [31860095]
- [QZYY-2022-020]
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Six diterpenoid alkaloids, including a previously undescribed compound, were isolated from a Delphinium plant. The potential anti-inflammatory effect of the new compound was evaluated.
Six diterpenoid alkaloids, namely, pachycentine (1), deacetylswinanine A (2), siwanine A (3), tatsiensine (4), deacetyltatsiensine (5), and 6-deoxydeltamine (6), were isolated from a China-specific Delphinium plant (family Ranunculaceae), Delphinium pachycentrum Hemsl. Their structures were established via detailed spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR techniques. Pachycentine (1) is a previously undescribed hetisine-type C-20-diterpenoid alkaloid, and compounds 5 and 6 were synthetic intermediates newly identified as natural products. In addition, compounds 2-4 were isolated from this species for the first time. The chemotaxonomic significance of all the isolates was summarized. Moreover, the new compound was evaluated for its potential anti-inflammatory effect using LPS-stimulated RAW 264.7 macrophages.
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