Two new eudesmane-type sesquiterpene derivatives from Lecokia cretica (Lam.) DC

Two new sesquiterpene glucosides, 1 alpha,6 beta,9 beta-trihydroxy-eudesm-4(15)-en-1,6-O-beta-diglucopyranoside (1) and 1 alpha,6 beta,9 beta-trihydroxy-eudesm-3-en-1,6-O-beta-diglucopyranoside (2) were obtained along with the 1 alpha,6 beta,9 beta-trihydroxy-5,10-bis-epi-eudesm-3-en-6-O-beta-D-glucopyranoside (3), chlorogenic acid (4), luteolin 7-O-rutinoside (5) and luteolin 7-O- glucoside (6) from the whole plant parts of Lecokia cretica. Their structures were determined on the basis of 1 D, 2 D NMR and HRMS analyses. The in vitro cytotoxic activity of compounds 1-3 against human lung cancer cells (A549) and normal human lung cells (BEAS-2B) was determined using the MTT colorimetric assay. All the tested eudesmane derivatives were found to be inactive.

Automated summary

Two new sesquiterpene glucosides were isolated from Lecokia cretica, with their structures confirmed through NMR and HRMS analyses. However, these compounds exhibited no cytotoxic activity against human lung cancer cells and normal lung cells in vitro.