Design and synthesis of a new bioactive compound for marine antifouling inspired by natural products

A marine antifouling compound, N-octyl-2-hydroxybenzamide (OHBA), inspired by ceramide and paeonol molecules, was created. First, methyl salicylate was synthesized with salicylic acid and methanol, followed by n-octylamine through an ester-amine condensation reaction. Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectrometry confirmed the characteristic structure of the OHBA compound. Bioassays showed that OHBA inhibits the growth of typical marine fouling organisms, such as Vibrio azureus, Navicula subminuscula, Ulva pertusa, Mytilus edulis, and Amphibalanus amphitrite, indicating its broad-spectrum antifouling ability. A one-year marine real-sea test further demonstrated the excellent antifouling properties of OHBA. OHBA is also extremely biodegradable, with a half-life of 6.3 days, making it a less environmentally harmful replacement for widely-used heavy metal-containing antifoulants.

Automated summary

Researchers have created a marine antifouling compound, OHBA, inspired by ceramide and paeonol molecules. OHBA has been shown to have broad-spectrum antifouling properties, inhibiting the growth of various marine fouling organisms. Additionally, OHBA is highly biodegradable, making it a more environmentally-friendly alternative.