Journal
NANOTECHNOLOGY
Volume 34, Issue 6, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1361-6528/aca02f
Keywords
DNA nanostructures; DNA origami; conformational transitions; thermal cycling
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The conformational transitions of biological macromolecules have inspired the construction of environmental responsive nanomachines. A thermal responsive DNA origami dimers system has been developed, which can cyclically switch conformations through thermal cycling. This strategy allows for repeated operation without significant performance degradation.
It is widely observed that life activities are regulated through conformational transitions of biological macromolecules, which inspires the construction of environmental responsive nanomachines in recent years. Here we present a thermal responsive DNA origami dimers system, whose conformations can be cyclically switched by thermal cycling. In our strategy, origami dimers are assembled at high temperatures and disassembled at low temperatures, which is different from the conventional strategy of breaking nanostructures using high temperatures. The advantage of this strategy is that the dimers system can be repeatedly operated without significant performance degradation, compared to traditional strategies such as conformational transitions via i-motif and G-quadruplexes, whose performance degrades with sample dilution due to repeated addition of trigger solutions. The cyclic conformational transitions of the dimers system are verified by fluorescence curves and AFM images. This research offered a new way to construct cyclic transformational nanodevices, such as reusable nanomedicine delivery systems or nanorobots with long service lifetimes.
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