Journal
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume 49, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.nano.2023.102662
Keywords
Colloidal carriers; Local delivery; Nanoparticulate system; Receptors; Targeted drug delivery
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Oral cancer is a deadly malignancy with high failure rates in current chemotherapeutic drugs due to toxicity and poor tumor targeting. Nanotechnology-based drug delivery systems hold great promise for precise targeting and improving patient health and survival rates in oral cancer.
Oral cancer is a type of cancer that develops in the mouth and is one of the deadliest malignancies in the world. Currently surgical, radiation therapy, and chemotherapy are most common treatments. Better treatment and early detection strategies are required. Chemotherapeutic drugs fail frequently due to toxicity and poor tumor targeting. There are high chances of failure of chemotherapeutic drugs due to toxicity. Active, passive, and immunity-targeting techniques are devised for tumor-specific activity. Nanotechnology-based drug delivery systems are the best available solution and important for precise targeting. Nanoparticles, liposomes, exosomes, and cyclodextrins are nano-based carriers for drug delivery. Nanotechnology is being used to develop new techniques such as intratumoral injections, microbubble mediated ultrasonic therapy, phototherapies, and site-specific delivery. This systematic review delves into the details of such targeted and nano-based drug delivery systems in order to improve patient health and survival rates in oral cancer. (c) 2023 Elsevier Inc. All rights reserved.
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