4.8 Article

Overcoming oxygen heterogeneity of tumor microenvironments to boost cancer immunotherapy by oxygen-switchable ROS/RNS nanogenerators

Journal

NANO TODAY
Volume 48, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2022.101696

Keywords

Oxygen-switchable ROS; RNS-releasing; polymers; Oxygen heterogeneity; Immunogenic cell death; Cancer immunotherapy

Ask authors/readers for more resources

In this study, smart materials capable of adapting to the pathological oxygen levels in tumors were developed to enhance cancer immunotherapy. These materials generate immunogenic stimuli that induce immunogenic cell death, stimulate dendritic cell maturation, and increase the infiltration of cytotoxic T cells into tumors, thus overcoming the oxygen heterogeneity in tumors and boosting immunotherapy.
The spatiotemporal heterogeneity of oxygen not only represents a hallmark of malignant tumors but also determines the degree and persistence of immunotherapy response in solid tumors. Smart materials that can adapt to pathological oxygen levels and generate immunogenic stimuli to improve immunotherapy are highly desirable. Here, we develop oxygen-switchable reactive oxygen species/nitrogen species nanogen-erators (RO/NS NGs) to overcome the oxygen heterogeneity of tumors and boost cancer immunotherapy. Upon receiving laser irradiation, the tetraphenylporphyrin moieties within RO/NS NGs serve as photo -sensitizers to generate ROS under normoxia and photocatalysts to activate nitric oxide donors to release RNS under hypoxia. Both ROS and RNS can induce immunogenic cell death in both normoxic and hypoxic tumor cells, stimulate dendritic cell maturation, and increase the infiltration of cytotoxic T cells into tumors. This work provides a feasible means for overcoming oxygen heterogeneity to boost immunotherapy.(c) 2022 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available