4.8 Article

Manipulating bioactivities of endothelial progenitor cell-derived exosomes for promoting angiogenesis in ischemic vascular diseases

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

LPA2 Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction

Jianqiu Pei et al.

Summary: This study found that the level of lysophosphatidic acid (LPA) was increased in the peripheral blood of mice after myocardial infarction (MI), and the expression of its receptor LPA(2) was also increased in the heart. Deficiency of Lpar2 led to impaired heart function, increased scar size, and reduced vascular density. Mechanistic studies demonstrated that LPA-LPA(2) signaling promoted angiogenesis and maintained vascular homeostasis through multiple signaling pathways.

CIRCULATION RESEARCH (2022)

Review Cell Biology

RNA-Binding Proteins: Emerging Therapeutics for Vascular Dysfunction

Victoria A. Cornelius et al.

Summary: Vascular diseases are a major cause of global mortality, and iPSC technologies provide powerful tools for studying vascular health. RBPs play important roles in vascular diseases, contributing to understanding of disease mechanisms and development of new therapies.

CELLS (2022)

Review Cardiac & Cardiovascular Systems

Angiogenesis after acute myocardial infarction

Xuekun Wu et al.

Summary: The translation describes how acute myocardial infarction causes damage to the coronary microcirculation, leading to vascular disintegration and capillary rarefication in the infarct region. Tissue repair after MI involves robust angiogenic response and interactions among various cell types through secreted proteins and receptors. Macrophages and fibroblasts have emerged as major drivers of the angiogenic response after MI, while understanding the mechanism of infarct angiogenesis creates therapeutic opportunities.

CARDIOVASCULAR RESEARCH (2021)

Article Cell & Tissue Engineering

GPR4 signaling is essential for the promotion of acid-mediated angiogenic capacity of endothelial progenitor cells by activating STAT3/VEGFA pathway in patients with coronary artery disease

Shun Ouyang et al.

Summary: This study found that the angiogenic capacity of EPCs from CAD patients declined in different pH environments, while EPCs from non-CAD individuals showed enhanced angiogenic capacity in acidic conditions. GPR4 expression in EPCs was significantly lower in CAD patients than in non-CAD individuals, and upregulation of GPR4 promoted neovessel formation in EPCs from CAD patients by activating the STAT3/VEGF signaling pathway.

STEM CELL RESEARCH & THERAPY (2021)

Article Cardiac & Cardiovascular Systems

New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease

Brian H. Annex et al.

Summary: PAD is a significant global cause of disability and mortality, primarily due to atherosclerotic obstructions in the large arteries to the leg(s). Despite advances in surgical and endovascular procedures, treatment outcomes may be suboptimal at times due to comorbid conditions or severe microvascular disease.

CIRCULATION RESEARCH (2021)

Review Medicine, General & Internal

Gene therapy for ischaemic heart disease and heart failure

H. Korpela et al.

Summary: Gene therapy has been expected as a novel treatment method for ischemic heart disease and heart failure. Clinical trials have shown improvements in myocardial perfusion and symptoms in CAD patients, but challenges such as successful transduction and patient selection still exist in translating preclinical success into clinical applications. New methods like retrograde delivery and cardiac-specific AAV vectors show promise for myocardial gene therapy.

JOURNAL OF INTERNAL MEDICINE (2021)

Article Chemistry, Multidisciplinary

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

Shiqi Hu et al.

Summary: In this study, stem cell-derived exosomes were hybridized with platelet membranes to enhance their targeting ability for injured hearts and reduce uptake by macrophages. The hybridization induced macropinocytosis, significantly increasing cellular uptake by endothelial cells and cardiomyocytes. In vivo studies demonstrated the cardiac targeting ability of these hybrid exosomes in a mouse model of myocardial infarction, suggesting a potential therapeutic benefit over non-modified exosomes.

NANO TODAY (2021)

Review Pharmacology & Pharmacy

Recent advances in nanomedicines for the treatment of ischemic stroke

Chao Li et al.

Summary: Ischemic stroke is a cerebrovascular disease caused by interrupted blood supply to the brain, leading to cell death and brain infarction. Nanomedicine offers new treatment possibilities by improving drug behavior and reducing side effects.

ACTA PHARMACEUTICA SINICA B (2021)

Review Medicine, Research & Experimental

Engineering exosomes for targeted drug delivery

Yujie Liang et al.

Summary: Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.

THERANOSTICS (2021)

Review Chemistry, Multidisciplinary

Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance

Shubham Salunkhe et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Medicine, Research & Experimental

Endothelial progenitor cell-derived exosomes ameliorate endothelial dysfunction in a mouse model of diabetes

Suwen Bai et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Medicine, General & Internal

Stem Cells in the Treatment of Disease

Helen M. Blau et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

E2F1 Suppresses Oxidative Metabolism and Endothelial Differentiation of Bone Marrow Progenitor Cells

Shiyue Xu et al.

CIRCULATION RESEARCH (2018)

Article Biotechnology & Applied Microbiology

Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis

Yue Zhou et al.

MOLECULAR THERAPY (2018)

Review Cardiac & Cardiovascular Systems

Examining the Paracrine Effects of Exosomes in Cardiovascular Disease and Repair

Melanie Gartz et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

Article Nanoscience & Nanotechnology

Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment

Kaiyue Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

Review Biotechnology & Applied Microbiology

Cardiovascular Gene Therapy: Past, Present, and Future

Seppo Yla-Herttuala et al.

MOLECULAR THERAPY (2017)

Review Cardiac & Cardiovascular Systems

Reducing the Global Burden of Cardiovascular Disease, Part 2 Prevention and Treatment of Cardiovascular Disease

Darryl P. Leong et al.

CIRCULATION RESEARCH (2017)

Article Cardiac & Cardiovascular Systems

Angiogenic Mechanisms of Human CD34+ Stem Cell Exosomes in the Repair of Ischemic Hindlimb

Prabhu Mathiyalagan et al.

CIRCULATION RESEARCH (2017)

Review Cardiac & Cardiovascular Systems

Exosomes Generated From iPSC-Derivatives New Direction for Stem Cell Therapy in Human Heart Diseases

Ji-Hye Jung et al.

CIRCULATION RESEARCH (2017)

Article Biochemistry & Molecular Biology

Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction

Mortimer Korf-Klingebiel et al.

NATURE MEDICINE (2015)