Improvement in time to multiple sclerosis diagnosis: 25-year retrospective analysis from New York State MS Consortium (NYSMSC)

Article Clinical Neurology

Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome A MAGNIMS Study

Massimo Filippi et al.

Summary: This study compares the performance of the 2017 revisions to the McDonald criteria with the 2010 criteria in diagnosing and predicting prognosis of multiple sclerosis (MS) in patients with clinically isolated syndrome (CIS). The results show that the 2017 criteria have higher sensitivity, lower specificity, and shorter time to MS diagnosis compared to the 2010 criteria.

NEUROLOGY (2022)

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Article Clinical Neurology

Discontinuation of disease modifying therapies is associated with disability progression regardless of prior stable disease and age

Dejan Jakimovski et al.

Summary: The study assessed the clinical course after treatment discontinuation in MS patients with long disease duration and found that patients with stable disease course might experience disability worsening after discontinuation, with no clear relation to age and disease subtype. Patients with EDSS >= 6.0 are at higher risk for disability worsening after discontinuation.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

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Article Clinical Neurology

Time to diagnosis in multiple sclerosis: Epidemiological data from the German Multiple Sclerosis Registry

Stefan J. Blaschke et al.

Summary: After the introduction of MRI-based McDonald criteria in 2001, the average time to diagnosis of multiple sclerosis in younger adults with relapsing onset has decreased in Germany. However, the diagnosis time remains longer and unchanged in pediatric onset MS patients.

MULTIPLE SCLEROSIS JOURNAL (2022)

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Article Clinical Neurology

Time to first treatment and risk of disability pension in relapsing-remitting multiple sclerosis

Malthe Faurschou Wandall-Holm et al.

Summary: Initiating treatment early reduces the risk of disability pension in patients with RRMS. This finding highlights the importance of early diagnosis and treatment on a patient-centered, socioeconomic disability milestone.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2022)

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Review Clinical Neurology

From the prodromal stage of multiple sclerosis to disease prevention

Ruth Ann Marrie et al.

Summary: This article discusses the importance of studying the prodromal stage of multiple sclerosis and the need to develop standardized criteria to accurately identify high-risk individuals for intervention.

NATURE REVIEWS NEUROLOGY (2022)

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Article Clinical Neurology

Effect of Changes in MS Diagnostic Criteria Over 25 Years on Time to Treatment and Prognosis in Patients With Clinically Isolated Syndrome

Mar Tintore et al.

Summary: This study found that the time to diagnosis and treatment initiation in CIS patients with MS has significantly decreased across different diagnostic criteria periods. Patients diagnosed in recent periods had a lower risk of reaching disability milestones compared to those diagnosed in earlier periods.

NEUROLOGY (2021)

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Review Clinical Neurology