Heteroaromatic Diazirines Are Essential Building Blocks for Material and Medicinal Chemistry

In materials (polymer) science and medicinal chemistry, heteroaromatic derivatives play the role of the central skeleton in development of novel devices and discovery of new drugs. On the other hand, (3-trifluoromethyl)phenyldiazirine (TPD) is a crucial chemical method for understanding biological processes such as ligand-receptor, nucleic acid-protein, lipid-protein, and protein-protein interactions. In particular, use of TPD has increased in recent materials science to create novel electric and polymer devices with comparative ease and reduced costs. Therefore, a combination of heteroaromatics and (3-trifluoromethyl)diazirine is a promising option for creating better materials and elucidating the unknown mechanisms of action of bioactive heteroaromatic compounds. In this review, a comprehensive synthesis of (3-trifluoromethyl)diazirine-substituted heteroaromatics is described.

Automated summary

In the fields of materials science and medicinal chemistry, heteroaromatic derivatives are important in developing new devices and discovering drugs. (3-trifluoromethyl)phenyldiazirine (TPD) is a crucial chemical method for understanding biological processes. TPD has been widely used in materials science to create novel electric and polymer devices at a lower cost. The combination of heteroaromatics and (3-trifluoromethyl)diazirine is a promising option for creating better materials and understanding the mechanisms of bioactive heteroaromatic compounds. This review provides a comprehensive synthesis of (3-trifluoromethyl)diazirine-substituted heteroaromatics.