Journal
MOLECULES
Volume 28, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/molecules28030947
Keywords
indole alkaloids; marine natural products; natural product syntheses; variolins; meridianins; meriolins
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Marine natural products are highly diverse and possess a wide range of biological activities. The (aza)indole alkaloids variolin B (1), meridianins (2), and their synthetic hybrids meriolins (3) have attracted significant interest due to their potent kinase inhibitory activities. This review provides an overview of the synthetic strategies employed to access these naturally occurring alkaloids and their semisynthetic derivatives.
Marine natural products are a source of essential significance due to a plethora of highly diverse biological properties. The naturally occurring (aza)indole alkaloids variolin B (1), meridianins (2), and their synthetic hybrids meriolins (3) exhibit potent kinase inhibitory activities and have aroused considerable interest in the past two decades. Therefore, the immense demand for versatile synthetic accesses to these structures has considerably increased. This review surveys the synthetic pathways to these naturally occurring alkaloids and their semisynthetic derivatives.
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