Journal
MOLECULES
Volume 27, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/molecules27249011
Keywords
hyperpigmentation; tyrosinase inhibitors; tyrosine; genus Morus
Ask authors/readers for more resources
The article focuses on the search for novel plant-derived anti-tyrosinase inhibitors from the Morus genus and their structure-activity relationships, providing crucial information for the cosmetics and medical industries.
Tyrosinase is a multifunctional, copper-containing and rate-limiting oxidase that catalyses crucial steps in the melanogenesis pathway and is responsible for skin-pigmentation abnormalities in mammals. Numerous tyrosinase inhibitors derived from natural and synthetic sources have been identified as an objective for the development of anti-melanogenesis agents. However, due to side effects and lack of expected efficiency, only a small percentage of them are used for medical and cosmetic purposes. This critical review focuses on searching for novel active substances and recently discovered plant-derived anti-tyrosinase inhibitors from the Morus genus (Moraceae family). A detailed analysis of their structure-activity relationships is discussed. The information contained in this article is crucial for the cosmetics and medical industries, in order to show new directions for the effective search for natural anti-melanogenesis products (with satisfactory efficiency and safety) to treat and cure hyperpigmentation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available