4.6 Review

Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions

Related references

Note: Only part of the references are listed.
Article Behavioral Sciences

Oral administration of cyclic glycyl-proline facilitates task learning in a rat stroke model

Hidekazu Kaneko et al.

Summary: Low-dose cGP group required fewer training days for task learning compared to the no-cGP group. Rats with larger lesions needed fewer training days in the no-cGP and low-cGP groups, but more in the high-cGP group. The number of Ki67-immunopositive cells in the ipsilesional SVZ increased more rapidly in the low-cGP and high-cGP groups.

BEHAVIOURAL BRAIN RESEARCH (2022)

Article Pharmacology & Pharmacy

A Phase 1, Open-Label Study to Evaluate the Effects of Food and Evening Dosing on the Pharmacokinetics of Oral Trofinetide in Healthy Adult Subjects

Mona Darwish et al.

Summary: This study investigated the potential effect of food on the pharmacokinetics of Trofinetide, a synthetic analog of tripeptide glycine-proline-glutamate, and characterized its pharmacokinetic profile in urine. The results showed that trofinetide can be administered without regard to food and there is no significant diurnal variation in bioavailability. Trofinetide is primarily excreted unchanged in urine and is well tolerated.

CLINICAL DRUG INVESTIGATION (2022)

Article Medicine, Research & Experimental

Design and outcome measures of LAVENDER, a phase 3 study of trofinetide for Rett syndrome

Jeffrey L. Neul et al.

Summary: A drug trial using trofinetide in females with Rett syndrome (RTT) showed significant improvement compared to placebo on multiple measures. A Phase 3 trial will further evaluate the efficacy and safety of trofinetide using disease-specific and novel scales to assess core symptoms of RTT, quality of life, and caregiver burden.

CONTEMPORARY CLINICAL TRIALS (2022)

Review Cell Biology

Relationship between circulating insulin-like growth factor-1 and blood pressure in adults: A systematic review and meta-analysis of observational studies

Lina Leng et al.

Summary: This study found a negative correlation between circulating IGF-1 levels and systolic blood pressure (SBP) and diastolic blood pressure (DBP). Subgroup analysis further revealed that the relationship between IGF-1 and BP was influenced by race and age. Further research is needed to explore the pathogenesis of this relationship and evaluate the role of IGF-1 in the treatment of hypertension.

GROWTH HORMONE & IGF RESEARCH (2021)

Article Endocrinology & Metabolism

The autocrine regulation of insulin-like growth factor-1 in human brain of Alzheimer?s disease

Dali Kang et al.

Summary: The study evaluated the changes of IGFBPs and cGP, and their effects on the bioavailability and function of IGF-1 in human brain of AD cases. The unbound bioavailable IGF-1 was lower whereas the bound cGP and IGFBP-3 were higher in AD than the control cases. Results provide direct evidence for IGF-1 deficiency in AD brain due to lower bioavailable IGF-1, and the increase of bound cGP is an autocrine response to improve the bioavailability and function of IGF-1 in AD brain.

PSYCHONEUROENDOCRINOLOGY (2021)

Review Pathology

Interplay between Brain Pericytes and Endothelial Cells in Dementia

Tessa Procter et al.

Summary: This review examines how dysfunction of the endothelial-pericyte crosstalk contributes to dementia, focusing on cerebral small vessel disease and Alzheimer disease. It highlights the disruption of the intimate crosstalk between endothelial cells and pericytes leading to alterations in cerebral blood flow, transcription, neuroinflammation, and breakdown of the BBB, which are major driving forces in dementia pathology.

AMERICAN JOURNAL OF PATHOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats

Fengxia Li et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2020)

Review Cardiac & Cardiovascular Systems

Alzheimer's Disease and Vascular Aging JACC Focus Seminar

Marta Cortes-Canteli et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Neurosciences

Hypertension accelerates cerebral tissue PO2 disruption in Alzheimer's disease

Xuecong Lu et al.

NEUROSCIENCE LETTERS (2020)

Review Neurosciences

Alzheimer's Disease: The Link Between Amyloid-β and Neurovascular Dysfunction

Ernesto Solis et al.

JOURNAL OF ALZHEIMERS DISEASE (2020)

Article Clinical Neurology

Plasma cyclic glycine proline/IGF-1 ratio predicts clinical outcome and recovery in stroke patients

Dawei Fan et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

Article Clinical Neurology

Cardiovascular risk factors and Parkinson's disease in 500,000 Chinese adults

Jennifer Kizza et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

Review Cell Biology

IGF-1 and cardiovascular disease

Yusuke Higashi et al.

GROWTH HORMONE & IGF RESEARCH (2019)

Article Medicine, Research & Experimental

Effect of Endogenous Neuropeptide Cycloprolylglycine on GABAA Receptors in Cerebellar Purkinje Cells

I. N. Sharonova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2019)

Article Psychology, Developmental

Framingham vascular age is associated with worse cognitive performance in the middle-aged and elderly

Abdul Badran et al.

AGING NEUROPSYCHOLOGY AND COGNITION (2019)

Article Geriatrics & Gerontology

The influence of vascular risk factors on cognitive function in early Parkinson's disease

Maxime Doiron et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2018)

Article Public, Environmental & Occupational Health

Cognitive Function and Vascular Risk Factors Among Older African American Adults

Ishan C. Williams et al.

JOURNAL OF IMMIGRANT AND MINORITY HEALTH (2018)

Article Clinical Neurology

Mild Cognitive Impairment as a Risk Factor for Parkinson's Disease Dementia

Jeroen Hoogland et al.

MOVEMENT DISORDERS (2017)

Review Pharmacology & Pharmacy

IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development

Ann Hellstrom et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

Article Multidisciplinary Sciences

Serum IGF-1 is associated with cognitive functions in early, drug-naive Parkinson's disease

Marina Picillo et al.

PLOS ONE (2017)

Article Biochemistry & Molecular Biology

Neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors

T. A. Gudasheva et al.

DOKLADY BIOCHEMISTRY AND BIOPHYSICS (2016)

Review Medicine, General & Internal

Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population

Krithika Srikanthan et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2016)

Article Peripheral Vascular Disease

Hypertension and lifetime risk of stroke

Tanvir Chowdhury Turin et al.

JOURNAL OF HYPERTENSION (2016)

Review Cardiac & Cardiovascular Systems

Stroke Severity Is a Crucial Predictor of Outcome: An International Prospective Validation Study

Natalia S. Rost et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2016)

Article Neurosciences

Vascular Health Indices and Cognitive Domain Function: Singapore Longitudinal Ageing Studies

Shir Lynn Lim et al.

JOURNAL OF ALZHEIMERS DISEASE (2016)

Review Pharmacology & Pharmacy

The role for IGF-1-derived small neuropeptides as a therapeutic target for neurological disorders

Jian Guan et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2015)

Article Biology

Modeling the effect of insulin-like growth factor-1 on human cell growth

Gemma M. A. Phillips et al.

MATHEMATICAL BIOSCIENCES (2015)

Article Peripheral Vascular Disease

Revisiting the Relationship Between Blood Pressure and Insulin- Like Growth Factor-1

Aletta Elisabeth Schutte et al.

HYPERTENSION (2014)

Article Multidisciplinary Sciences

Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1

Jian Guan et al.

SCIENTIFIC REPORTS (2014)

Review Cardiac & Cardiovascular Systems

The effects of hypertension on the cerebral circulation

Paulo W. Pires et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2013)

Review Endocrinology & Metabolism

The GH/IGF-1 axis in ageing and longevity

Riia K. Junnila et al.

NATURE REVIEWS ENDOCRINOLOGY (2013)

Article Behavioral Sciences

Age-related memory decline is associated with vascular and microglial degeneration in aged rats

Rong Zhang et al.

BEHAVIOURAL BRAIN RESEARCH (2012)

Article Geriatrics & Gerontology

The Emerging Role of IGF-1 Deficiency in Cardiovascular Aging: Recent Advances

Zoltan Ungvari et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2012)

Article Geriatrics & Gerontology

Aging, Synaptic Dysfunction, and Insulin-Like Growth Factor (IGF)-1

Ferenc Deak et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2012)

Article Neurosciences

Reduced brain insulin-like growth factor I function during aging

Alexandre Pastoris Muller et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2012)

Article Peripheral Vascular Disease

Vascular Mechanisms in the Pathogenesis of Stroke

Cristina Sierra et al.

CURRENT HYPERTENSION REPORTS (2011)

Article Endocrinology & Metabolism

Serum IGF-I Levels Correlate to Improvement of Functional Outcome after Ischemic Stroke

Daniel Aberg et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Article Clinical Neurology

Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study)

W. G. J. Reid et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2011)

Article Medicine, Research & Experimental

Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females

Silvia Savastano et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2011)

Article Clinical Neurology

Increased serum insulin-like growth factor 1 in early idiopathic Parkinson's disease

Jana Godau et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2010)

Article Pharmacology & Pharmacy

A novel diketopiperazine improves functional recovery given after the onset of 6-OHDA-induced motor deficit in rats

R. V. M. Krishnamurthi et al.

BRITISH JOURNAL OF PHARMACOLOGY (2009)

Article Geriatrics & Gerontology

Plasma IGF-I levels and cognitive performance in older women

Olivia Okereke et al.

NEUROBIOLOGY OF AGING (2007)

Article Endocrinology & Metabolism

Midlife plasma insulin-like growth factor I and cognitive function in older men

Olivia I. Okereke et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2006)

Article Multidisciplinary Sciences

Insulin-like growth factor I is required for vessel remodeling in the adult brain

C Lopez-Lopez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Neurosciences

Insulin-like growth factor-1 and post-ischemic brain injury

J Guan et al.

PROGRESS IN NEUROBIOLOGY (2003)

Article Medicine, Research & Experimental

Proline-containing dipeptide GVS-111 retains nootropic activity after oral administration

RU Ostrovskaya et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2001)

Review Endocrinology & Metabolism

Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities

RC Baxter

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2000)