Journal
MOLECULES
Volume 27, Issue 24, Pages -Publisher
MDPI
DOI: 10.3390/molecules27248856
Keywords
Eupatorium heterophyllum; Asteraceae; benzofuran oligomer; structure elucidation; Hengduan mountain
Funding
- JSPS [16K18897, 25303010, 20K07102]
- NSFC
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This study investigated the chemical constituents of two root samples of Eupatorium heterophyllum DC. collected in Yunnan Province, China. New benzofurans and derivatives were isolated, and their structures were determined. It is the first time that oligomeric benzofurans have been found in this plant, indicating the ongoing diversification of secondary metabolites in E. heterophyllum.
The chemical constituents of two root samples of Eupatorium heterophyllum DC. collected in Yunnan Province, China, were investigated. Five new oligomeric benzofurans (1-5), nine new benzofuran/dihydrobenzofuran derivatives, and a new thymol analog were isolated, and their structures were determined using extensive spectroscopic techniques, such as 1D and 2D NMR spectroscopy and DFT calculations of the CD spectra. Most of the new compounds, including oligomeric benzofurans (1-5), were obtained from only one of the root samples. Furthermore, this is the first example that produces oligomeric benzofurans in this plant. These results imply that diversification of secondary metabolites in E. heterophyllum is ongoing. Plausible biosynthetic pathways for 1-5 are also proposed.
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