Journal
MOLECULES
Volume 27, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/molecules27227794
Keywords
levesquamide; GNPS; marine natural product; Streptomyces
Funding
- Innovation PEI
- Canada Research Chair Program
- Atlantic Canada Opportunities Agency
- Jeanne and Jean-Louis Levesque Foundation
- Canada Foundation for Innovation
- Natural Sciences and Engineering Council of Canada
- Nautilus Biosciences Croda
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Levesquamide A is an anti-tubercular natural product, and additional members of the levesquamide family have been identified using GNPS. Levesquamide B has been structurally elucidated, while the structures of levesquamide C, D, and the other three levesquamides remain ambiguous.
Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from Streptomyces sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, isolated and structurally elucidated via spectroscopical techniques along with the putative structures of levesquamide C and D. For masses relating to the additional three levesquamides (E-G), their complete structures remain ambiguous.
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