Journal
MOLECULES
Volume 28, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/molecules28010308
Keywords
1; 2; 3-triazole; multicomponent reaction; intramolecular azide-alkyne cycloaddition; dipolar cycloaddition
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This review summarizes several reports on the synthesis of fused 1,2,3-triazole containing scaffolds using a sequential multicomponent reaction-intramolecular azide-alkyne cycloaddition approach. The reactions were carefully designed to incorporate azide and alkyne functionalities in the MCR product, which was then subjected to IAAC. The review is divided into two sections based on the number of components in the multicomponent reaction, and provides a critical discussion and analysis of the advantages and disadvantages of each methodology.
The present review narrates several reports which deal with the synthesis of fused 1,2,3-triazole containing scaffolds following a sequential multicomponent reaction (MCR)-intramolecular azide-alkyne cycloaddition (IAAC) approach. The reviewed reactions were cleverly designed so as to incorporate azide and alkyne functionalities in the MCR product which was then subjected to IAAC. The review is divided into two sections based on the number of components in the multicomponent reaction. We have aimed at a critical discussion and also have highlighted either advantages or disadvantages of each methodology.
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