Journal
MOLECULES
Volume 27, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/molecules27228034
Keywords
Hottonia palustris; Primulaceae; flavonoids; LC-HRMS; antioxidant activity; acetylcholinesterase inhibition
Funding
- Medical University of Bialystok [SUB/2/DN/22/002/2212]
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Hottonia palustris, a plant from the genus Hottonia, was studied for its phytochemical and pharmacological properties. Eleven compounds, including three new flavonoids, were isolated and characterized. The active compound, dibenzoylmethane, showed potential antioxidant and acetylcholinesterase inhibitory activities. H. palustris may serve as a valuable source of substances for the prevention and treatment of neurodegenerative diseases.
Hottonia palustris L. is from the genus Hottonia (Primulaceae), and the understanding of its phytochemical and pharmacological properties is limited. In this study, the use of chromatographic techniques led to the isolation of a further eleven compounds, including three new flavonoids: 2 ',5-dihydroxyflavone 2 '-O-beta-glucopyranoside, 5,6-dihydroxyflavone 6-O-(6-O-glucopyranosyl)-beta-glucopyranoside (hottonioside A), and 4 ',5,7-trihydroxyflavone 7-O-(2-O-beta-glucuronide)-beta-glucopyranoside. Their structures were determined using extensive 1D and 2D NMR data and mass spectrometry (HRMS). The qualitative assessment of the chemical composition of the investigated extracts and fractions was performed using the LC-HRMS technique. Furthermore, the antioxidant potential of extracts, fractions, and compounds and their ability to inhibit acetylcholinesterase were also evaluated. Thus, we may conclude that the observed biological effects are the result of the presence of many biologically active compounds, of which dibenzoylmethane is the most active. Therefore, H. palustris is a source of substances with desirable properties in the prevention and treatment of neurodegenerative diseases.
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