Rapid Capillary Electrophoresis Method for Simultaneous Determination of Abemaciclib, Ribociclib, and Palbociclib in Pharmaceutical Dosage Forms: A Green Approach

Editorial Material Chemistry, Medicinal

European Pharmacopoeia Activities on Control of Nitrosamines and other DNA-Reactive Impurities

Ulrich Rose

JOURNAL OF PHARMACEUTICAL SCIENCES (2023)

Article Chemistry, Medicinal

Development and Validation of a Novel LC-MS/MS Method for the Simultaneous Determination of Abemaciclib, Palbociclib, Ribociclib, Anastrozole, Letrozole, and Fulvestrant in Plasma Samples: A Prerequisite for Personalized Breast Cancer Treatment

Lu Turkovic et al.

Summary: A novel bioanalytical LC-ESI-MS/MS method was developed for the quantitation of six breast cancer chemotherapeutic drugs in human plasma. The method was validated and successfully applied to patient samples.

PHARMACEUTICALS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Inhibiting CDK4/6 in Breast Cancer with Palbociclib, Ribociclib, and Abemaciclib: Similarities and Differences

C. Louwrens Braal et al.

Summary: CDK 4/6 inhibitors are a new class of drugs that interrupt proliferation of malignant cells by inhibiting progression through the cell cycle. This article reviews the clinical pharmacokinetic and pharmacodynamic profiles of these inhibitors and discusses important future directions for their clinical applicability.

DRUGS (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Biochemical Research Methods

Establishment of an analytical method for simultaneous quantitation of CDK4/6 inhibitors, aromatase inhibitors, and an estrogen receptor antagonist in human plasma using LC-ESI-MS/MS

Yu Sato et al.

Summary: A novel liquid chromatography/electrospray ionization tandem mass spectrometry method was developed for the simultaneous quantitation of CDK4/6 inhibitors, aromatase inhibitors, and the estrogen receptor antagonist. The method showed good accuracy and stability, making it suitable for therapeutic drug monitoring and pharmacokinetics/pharmacodynamics research in anticancer drugs.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Can we replace liquid chromatography with the greener capillary electrophoresis?

Muhandiramge Ranasinghe et al.

Summary: Liquid phase separations, including liquid chromatography (LC) and capillary electrophoresis (CE), are crucial in chemical analysis. This review compares the analytical performance of LC and CE for the analysis of the same compounds, covering different modes and recommending CE as a potential replacement for some applications.

CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY (2021)

Add to Collection

Article Chemistry, Analytical

Green, Cost-Effective Simultaneous Assay of Chloramphenicol, Methylparaben, and Propylparaben in Eye-Drops by Capillary Zone Electrophoresis

Thi Thanh Vuong Tong et al.

Summary: A green, cost-effective, and simple capillary zone electrophoresis method was developed and validated for simultaneous determination of chloramphenicol, methylparaben, and propylparaben in eye-drops. The most suitable electrophoretic conditions included a 30mM sodium tetraborate solution, pH 9.3 as BGE, working voltage set at 25kV, and UV detection at 280nm at the cathodic extremity of the capillary, proving to be reliable for assay of the target compounds.

JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY (2021)

Add to Collection

Article Oncology