Journal
MOLECULES
Volume 27, Issue 23, Pages -Publisher
MDPI
DOI: 10.3390/molecules27238538
Keywords
2-aminobenzofurans; isocyanides; ortho-quinone methides; [4+1] cycloaddition
Funding
- Key Research and Development Program of Sichuan Province
- National Natural Science Foundation of China
- [2022YFS0001]
- [21672205]
- [21772192]
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A new method for the synthesis of 2-aminobenzofurans using Sc(OTf)(3) has been described, utilizing o-QMs as intermediates and providing a straightforward and efficient approach for the construction of the scaffold.
A new approach for the synthesis of 2-aminobenzofurans has been described via Sc(OTf)(3) mediated formal cycloaddition of isocyanides with the in situ generated ortho-quinone methides (o-QMs) from o-hydroxybenzhydryl alcohol. Notably, as a class of readily available and highly active intermediates, o-QMs were first used in the construction of benzofurans. This [4 + 1] cycloaddition reaction provides a straightforward and efficient methodology for the construction of 2-aminobenzofurans scaffold in good yield (up to 93% yield) under mild conditions.
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