Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer's Disease

Review Food Science & Technology

Effects and mechanisms of natural products on Alzheimer's disease

Zhijun Yang et al.

Summary: Alzheimer's disease (AD) is the most common form of dementia in elderly people, and natural products and bioactive compounds have potential in preventing and treating AD.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

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Review Neurosciences

Therapeutic Effects of Thymoquinone on Alzheimer's Disease through Modulating Amyloid-beta Neurotoxicity and Neuro-inflammatory Cytokine Levels

Fawaz Alasmari et al.

Summary: Alzheimer's disease (AD) is a neurodegenerative disease associated with impaired neuronal pathways. Modulating the amyloid-beta system is being tested as a treatment for AD. Thymoquinone, an active ingredient in Nigella sativa, has shown therapeutic effects in AD models by attenuating beta-amyloid neurotoxicity and neuroinflammation.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2023)

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Article Plant Sciences

Anti-neuroinflammatory effects of alkaloid-enriched extract from Huperzia serrata on lipopolysaccharide-stimulated BV-2 microglial cells

Thu Kim Dang et al.

Summary: The alkaloid-enriched extract of Huperzia serrata (Thunb.) Trevis (Lycopodiaceae) has been found to have anti-neuroinflammatory effects on LPS-stimulated BV-2 cells. Pre-treatment with the extract was more effective in suppressing inflammation compared to post-treatment. The extract regulates the MAPK signaling pathway to alleviate neuroinflammation.

PHARMACEUTICAL BIOLOGY (2023)

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Article Neurosciences

Naringin enhances long-term potentiation and recovers learning and memory deficits of amyloid-beta induced Alzheimer?s disease-like behavioral rat model

Ga-Young Choi et al.

Summary: Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive learning and memory impairment. Naringin has therapeutic potential to reduce neuronal inflammation and apoptosis induced by A beta related with the BDNF/ TrkB/CREB signaling.

NEUROTOXICOLOGY (2023)

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Article Biochemistry & Molecular Biology

Protective Effects of Ginkgolide on a Cellular Model of Alzheimer's Disease via Suppression of the NF-κB Signaling Pathway

Tian-Tong Niu et al.

Summary: This study investigates the effects of ginkgolide on cell viability in an AD cellular model and explores its mechanisms related to NF-kappa B signaling. The results suggest that ginkgolide enhances cell viability and exerts neuroprotective effects on AD, at least partially through the suppression of the NF-kappa B signaling pathway involving anti-apoptosis and anti-inflammation mechanisms.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2022)

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Review Environmental Sciences

Potential of flavonoids as anti-Alzheimer's agents: bench to bedside

Rajwinder Kaur et al.

Summary: Developing therapies for neurodegenerative diseases, especially Alzheimer's, is challenging. Flavonoids have shown potential in treating Alzheimer's by slowing neuronal degeneration and crossing the blood-brain barrier.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Regulation of acetylcholinesterase during the lipopolysaccharide-induced inflammatory responses in microglial cells

Yingjie Xia et al.

Summary: This study explores the role of AChE in neuroinflammation and finds that AChE expression is upregulated during inflammation, while ACh or α7 nAChR agonists can suppress the production of pro-inflammatory cytokines and the phagocytosis of microglia.

FASEB JOURNAL (2022)

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Article Endocrinology & Metabolism

Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease

Li Shao et al.

Summary: This study found that Ginkgolide B (GB) exerts a neuroprotective effect on the cognitive function of SAMP8 mice by suppressing the activation of NLRP3 inflammasome via autophagic degradation.

METABOLIC BRAIN DISEASE (2022)

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Article Endocrinology & Metabolism

Neuroprotective role of Diosgenin, a NGF stimulator, against Aβ (1-42) induced neurotoxicity in animal model of Alzheimer's disease

Swati Som et al.

Summary: This study found that diosgenin has a neuroprotective effect in a rat model of Alzheimer's disease, improving learning and memory, reducing plaque load, oxidative stress, neuroinflammation, and acetylcholinesterase activity.

METABOLIC BRAIN DISEASE (2022)

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Review Biochemistry & Molecular Biology

Structure, synthesis, biosynthesis, and activity of the characteristic compounds from Ginkgo biloba L.

Xin-Guang Liu et al.

Summary: Ginkgo biloba is a unique plant with compounds that broaden the chemical diversity of herbal medicine, used for cardiovascular disease prevention and treatment. However, traditional extraction methods yield low purity and content of active compounds, highlighting the need for new strategies to meet international market demand.

NATURAL PRODUCT REPORTS (2022)

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Review Cell Biology

Pathological mechanisms and therapeutic strategies for Alzheimer's disease

Yaojun Ju et al.

Summary: Alzheimer's disease is a complex neurodegenerative disease characterized by synaptic dysfunctions and neurotransmitter deficiencies. The pathological features of Alzheimer's disease include changes in β-amyloid and tau proteins. Aging and other factors are also risk factors for the disease. Therefore, developing treatment strategies that target different pathological factors is crucial.

NEURAL REGENERATION RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome

Takumi Satoh et al.

Summary: This article reviews the potential applications of carnosic acid (CA) and carnosol (CS) in rosemary for conditions such as Alzheimer's disease, Parkinson's disease, and COVID-19. It highlights the antioxidant, anti-inflammatory, and neuroprotective effects of CA, as well as its potential to inhibit the NLRP3 inflammasome. The article suggests that CA-related compounds could serve as therapeutics for acute and chronic neurological effects caused by SARS-CoV-2 infection and other neurodegenerative diseases.

ANTIOXIDANTS (2022)

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Article Clinical Neurology

First causally acting Drug against Alzheimer's? The FDA approves Aducanumab

Klaus Hager

NERVENARZT (2022)

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Review Biochemistry & Molecular Biology

Flavonoids as Potential Anti-Inflammatory Molecules: A Review

Jameel M. Al-Khayri et al.

Summary: Hydroxylated polyphenols, or flavonoids, are plant-based compounds with various medicinal properties, including anti-inflammatory effects. They activate antioxidant pathways, regulate cytokine expression, and inhibit pro-inflammatory enzyme activity, providing potential treatment options for inflammatory diseases. Understanding the anti-inflammatory action of flavonoids is important for improving human health.

MOLECULES (2022)

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Review Cell Biology

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Prabhakar Semwal et al.

Summary: This review provides an overview of the pharmacological effects of diosgenin based on in vitro, in vivo, and clinical studies, as well as discussing the safety issues. The preclinical studies have shown promising effects on various pathologies, such as cancer, neuroprotection, atherosclerosis, asthma, and bone health. Clinical investigations have demonstrated the nontoxic nature of diosgenin and its potential benefits on cognitive function and menopause. However, further well-designed clinical trials and a better understanding of its safety profile are needed to address other potential effects.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Chemistry, Medicinal

Antiinflammatory activity of natural triterpenes-An overview from 2006 to 2021

Rodrigo de Souza Miranda et al.

Summary: This review provides an overview of the anti-inflammatory effects of various triterpenes and their presumed mechanisms of action, based on articles published in the last 15 years. The findings suggest that triterpenes could be valuable natural products with potential pharmaceutical applications.

PHYTOTHERAPY RESEARCH (2022)

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Article Cell Biology

Inhibition of the CEBPβ-NFκB interaction by nanocarrier-packaged Carnosic acid ameliorates glia-mediated neuroinflammation and improves cognitive function in an Alzheimer's disease model

Wang Yi-Bin et al.

Summary: Neuroinflammation occurs early in Alzheimer's disease, and this study found that carnosic acid can alleviate inflammatory mediator-induced neuronal degeneration and reduce A beta secretion through inhibiting the CEBP beta-NF kappa B signaling pathway, providing potential therapeutic agents for AD treatment.

CELL DEATH & DISEASE (2022)

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Review Pharmacology & Pharmacy

Focusing on Formononetin: Recent Perspectives for its Neuroprotective Potentials

Jiao Tian et al.

Summary: The nervous system is complex and lacks effective treatment strategies for neurological diseases. Natural products such as formononetin, a non-steroidal isoflavonoid, have shown potential in treating neurological disorders due to their anti-inflammatory, antioxidant and anti-cancer effects. Formononetin exhibits neuroprotective properties in various neurological diseases, and more clinical trials are needed to confirm its efficacy and safety before clinical application.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Medicine, Research & Experimental

The Aptamer Ob2, a novel AChE inhibitor, restores cognitive deficits and alleviates amyloidogenesis in 5xFAD transgenic mice

Zhiman Liang et al.

Summary: In this study, the DNA aptamer Ob2 showed effective inhibition of AChE activity and improved cognitive ability in a mouse model of AD. The mechanism of action may involve inhibition of AChE activity, reduction of A beta expression through lowering BACE1 levels, and activation of astrocytes.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Review Chemistry, Multidisciplinary

Research Advances on Matrine

Xiao-Ying Sun et al.

Summary: Matrine, an alkaloid extracted from traditional Chinese herbs, combines the advantages of traditional herbs and chemotherapy drugs, showing distinct benefits in preventing and improving chronic diseases. Recent research has focused on its anti-atherosclerosis, anti-tumor, and anti-inflammatory properties, providing new insights for drug development in related fields.

FRONTIERS IN CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Multifunctional Anti-Alzheimer's Disease Effects of Natural Xanthone Derivatives: A Primary Structure-Activity Evaluation

Xiaoyu Hu et al.

Summary: This study discovered that both alpha-M and its derivative Zcbd-3 had similar effects in anti-Alzheimer's disease. The results also indicated that the 3-methyl-2-butenyl group at C-8 is important for the bioactivity of alpha-M, and modification of the double hydroxylation at the C-2 position may improve its anti-AD effects.

FRONTIERS IN CHEMISTRY (2022)

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Review Biochemistry & Molecular Biology

Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review

Jana Klose et al.

Summary: Neurodegenerative disorders, such as Parkinson's disease, Huntington's disease, and Alzheimer's disease, are urgent medical needs worldwide. Despite advancements in understanding the development and pathology of these diseases, there are currently no treatments available to stop the progression of Alzheimer's disease. The recent approval of sodium oligomannate for Alzheimer's disease treatment in China highlights the potential value of natural products in the treatment of neurodegenerative disorders. Many clinical studies are currently exploring the use of natural compounds, particularly those with anti-inflammatory and anti-oxidative activities, for neuroprotection.

BIOMOLECULES (2022)

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Article

Diosgenin: mechanistic insights on its anti-inflammatory effects

Somayyeh Karami-Mohajeri et al.

Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry (2022)

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Review Chemistry, Applied

Advances in polysaccharides of natural source of the anti-Alzheimer's disease effect and mechanism

Zhiyuan Zhang et al.

Summary: This paper reviews recent research on the regulation of natural polysaccharides in Alzheimer's disease (AD) and systematically lists possible intervention pathways of polysaccharides targeting different mechanisms.

CARBOHYDRATE POLYMERS (2022)

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Review Biochemistry & Molecular Biology

The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer's Disease

Emily Sun et al.

Summary: This review provides an overview of the role of NF-kappa B in the pathogenesis of Alzheimer's Disease (AD), including its interaction with various molecular factors in AD models, neurons, and glial cells. With the multifactorial nature of AD development and the failure of many drugs, targeting the NF-kappa B signaling pathway may generate widespread interest in AD research and provide more therapeutic options for AD patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Immunology

Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer's disease

Yue Dong et al.

Summary: This study revealed, for the first time, that hyperphosphorylated tau (pTau) induces necroptosis and inflammation in Alzheimer's disease (AD) by activating the RIPK1/RIPK3/MLKL and NF-kappa B pathways, thereby contributing to neuronal death.

JOURNAL OF NEUROINFLAMMATION (2022)

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Review Cell Biology

Therapeutic Potential of Different Natural Products for the Treatment of Alzheimer's Disease

Biswajit Chakraborty et al.

Summary: A high incidence of dementia and memory loss are common symptoms of Alzheimer's disease (AD), a neurodegenerative disorder that primarily affects the elderly. Traditional Chinese medicine (TCM) and Indian medicines have been recommended as potential preventive and curative approaches for AD. Neuroinflammation, particularly linked to the deposition of amyloid-beta in the brain, is believed to play a significant role in the pathophysiology of AD. This review focuses on the role of neuroinflammation in neuroprotection and the potential of diverse natural substances and herbal formulations in treating AD. However, further research is needed to fully understand the effectiveness of TCM and Indian Ayurveda in AD treatment.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Pharmacology & Pharmacy

Progress on structural modification of Tetrandrine with wide range of pharmacological activities

Liuying Mo et al.

Summary: This paper summarizes the anti-tumor and anti-inflammatory mechanisms, clinical applications, and recent advances in the chemical structure modification and nanocarrier delivery of Tetrandrine (Tet). Chemical modifications and nanocarrier delivery have been shown to address the limitations of Tet and improve its pharmacological activity.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Behavioral Sciences

Formononetin: A Pathway to Protect Neurons

Xiaoyu Ma et al.

Summary: Formononetin (FMN) is a phytoestrogen with pharmacological effects of antioxidation, antihypertension, antitumor, and anti-infection. It has significant potential in neuroprotection and can be used for the treatment of various neurological diseases.

FRONTIERS IN INTEGRATIVE NEUROSCIENCE (2022)

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Review Multidisciplinary Sciences

Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer's disease

Fabiha Zaheen Khan et al.

Summary: Black cumin and its main bioactive compound, thymoquinone (TQ), have potential effects in preventing and treating Alzheimer's disease through antioxidative, anti-inflammatory, antiapoptotic properties, and inhibiting altered signaling pathways.

HELIYON (2022)

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Article Medicine, Research & Experimental

Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside isolated from the flowers of Hosta plantaginea exerts anti-inflammatory activity via suppression of NF-?B, MAPKs and Akt pathways in RAW 264.7 cells

Yiwei Fang et al.

Summary: This study explored the anti-inflammatory effect and potential molecular mechanisms of Kaempferol 3-O-(2(G)-glucosylrutinoside)-7-O-glucoside (KGG) in cells. KGG inhibited the secretion of inflammatory mediators and attenuated the activation of NF-kappa B, MAPKs, and Akt signaling pathways.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Review Biochemistry & Molecular Biology

Glial Cell-Mediated Neuroinflammation in Alzheimer's Disease

Nour F. Al-Ghraiybah et al.

Summary: This review provides an overview of recent advances on the role of microglia and astrocytes in neuroinflammation and provides updates on neuroinflammation diagnostic markers and investigational therapeutics currently in clinical trials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Pharmacology & Pharmacy

Anti-inflammatory effect evaluation of naringenin and its incorporation into a chitosan-based film for transdermal delivery

Wanessa S. C. Quintao et al.

Summary: This study aims to develop a chitosan-based film for the transdermal delivery of naringenin, a bioflavonoid with anti-inflammatory activity, for long-term treatment of inflammatory conditions. The study found that naringenin has anti-inflammatory effects and can inhibit T-cell proliferation. A chitosan film was successfully developed, which can continuously release naringenin across the skin over 72 hours.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Chemistry, Multidisciplinary

Total Synthesis of Ginkgolide C and Formal Syntheses of Ginkgolides A and B

Martin Hebert et al.

Summary: Ginkgolides are compounds isolated from Ginkgo biloba that have anti-inflammatory and neuroprotective properties. This article reports the total synthesis of ginkgolide C and the formal syntheses of ginkgolides A and B, using a functional group strategy guided by the compact structure of ginkgolides.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Biochemistry & Molecular Biology

Isolation of Phenolic Compounds from Raspberry Based on Molecular Imprinting Techniques and Investigation of Their Anti-Alzheimer's Disease Properties

Qian Wu et al.

Summary: Raspberry fruits contain phenolic components with antioxidant and anti-inflammatory properties. Molecular imprinting technology was used to efficiently isolate these components. Among them, ellagic acid, tiliroside, and kaempferol-3-o-rutoside showed better anti-inflammatory and anti-Alzheimer's potential.

MOLECULES (2022)

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Review Pharmacology & Pharmacy

Potential therapeutic effects and pharmacological evidence of sinomenine in central nervous system disorders

Hongxiang Hong et al.

Summary: Sinomenine, a natural compound from Sinomenium acutum, has shown beneficial effects in various CNS disorders, including cerebral ischemia, traumatic brain injury, Alzheimer's disease, Parkinson's disease, and epilepsy. Its mechanisms of action involve inhibition of oxidative stress, neuroinflammation, and neuronal apoptosis. Sinomenine also exhibits anti-glioma effects and improves morphine dependence and sleep disturbance.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Selected Natural Products in Neuroprotective Strategies for Alzheimer's Disease-A Non-Systematic Review

Karolina Wojtunik-Kulesza et al.

Summary: Neurodegenerative disorders, particularly Alzheimer's disease (AD), involve irreversible degeneration of the central nervous system. AD, the most common neurodegenerative disorder, lacks effective treatment options. Plant-based natural products are being explored for their neuroprotective activities and minimal side effects. This review highlights the anti-AD properties of various natural plant substances and their mechanisms of action, with the aim of discovering potent AD medicines with fewer side effects.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Chemistry, Applied

Anti-inflammatory steroids from the fruits of Artocarpus heterophyllus

Yun-Yao Liu et al.

Summary: A phytochemical study on the fruits of Artocarpus heterophyllus led to the isolation of a previously undescribed steroid and seven known analogues, all separated from the plant for the first time. The compounds showed remarkable inhibitory effects against nitric oxide production in vitro.

NATURAL PRODUCT RESEARCH (2021)

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Review Endocrinology & Metabolism

Berberine as a Potential Multi-Target Agent for Metabolic Diseases: A Review of Investigations for Berberine

Shengju Wang et al.

Summary: Berberine, extracted from Coptis chinensis, demonstrates various properties like anti-hyperglycemia, anti-obesity, and anti-inflammation, with the ability to improve insulin resistance and regulate intestinal flora. Given the growing prevalence of metabolic disorders and diseases globally, Berberine's metabolic properties show potential for effectively treating metabolic diseases.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2021)

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Article Biochemistry & Molecular Biology

Design, Synthesis, and Activity Study of Cinnamic Acid Derivatives as Potent Antineuroinflammatory Agents

Shun Huang et al.

Summary: Neuroinflammatory cytokines are promising therapeutic targets for Alzheimer's disease, and cinnamic acid derivatives, particularly compound 4f, have shown potential as effective antineuroinflammatory agents. Through structural modifications, compound 4f was found to directly bind to the MAPK signaling pathway, blocking neuroinflammatory progression. Docking studies further revealed the compound's interaction with IL-1 beta and enhanced binding affinity, which are significant for Alzheimer's disease treatment development.

ACS CHEMICAL NEUROSCIENCE (2021)

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Review Biochemistry & Molecular Biology

Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti-inflammatory activity, and the gut microbiota-liver-brain axis

James W. Daily et al.

Summary: Luteolin, a widely distributed flavone compound found in herbs and vegetables, has antioxidant and anti-inflammatory properties and can improve glucose metabolism. It can protect the brain from Alzheimer's disease development through modulation of insulin sensitivity, neuroinflammation, and the gut microbiota-liver-brain axis. Further research is needed to validate its effects in human clinical trials.

BIOFACTORS (2021)

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Review Chemistry, Medicinal

Neuroprotective mechanisms of mangiferin in neurodegenerative diseases

Tingjun Liu et al.

Summary: This review summarizes the latest research on the neuroprotective effects of Mangiferin (MGF) and its diverse molecular mechanisms in central nervous system (CNS) disorders.

DRUG DEVELOPMENT RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Synthesis and activities of acetylcholinesterase inhibitors

Shiyang Zhou et al.

Summary: Cholinesterase inhibitors can be divided into two categories: acetylcholinesterase and butylcholinesterase inhibitors. The development of selective inhibition of AChE and BuChE activities is a central focus of ChE pharmacochemistry research. In the past decade, there has been significant progress in understanding the pharmacological properties of selective AChE inhibitors, aiming to develop more effective and selective inhibitors.

CHEMICAL BIOLOGY & DRUG DESIGN (2021)

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Article Clinical Neurology

Oxidative Damage of Proteins Precedes Loss of Cholinergic Phenotype in the Septal Neurons of Olfactory Bulbectomized Mice

O. A. Nedogreeva et al.

Summary: The development of cholinergic deficit is considered an early sign of pathological conditions including Alzheimer's disease. In the olfactory bulbectomy model, oxidative damage of proteins may cause cholinergic dysfunction rather than irreversible neuronal damage, indicating the sensitivity of basal forebrain cholinergic neurons to oxidative stress which may contribute to early cognitive decline in Alzheimer's disease.

CURRENT ALZHEIMER RESEARCH (2021)

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Review Clinical Neurology

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

Alberto Serrano-Pozo et al.

Summary: The APOE ε4 allele and ε2 allele are respectively the strongest genetic risk factor and protective factor for Alzheimer's disease. While therapies targeting APOE are currently unavailable, recent research has expanded our understanding of APOE pathogenesis to include multiple pathological processes, offering valuable insights for therapy development.

LANCET NEUROLOGY (2021)

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Article Agriculture, Multidisciplinary

Protective Effect of Ginkgolide B against Cognitive Impairment in Mice via Regulation of Gut Microbiota

Jiaming Liu et al.

Summary: The study revealed that Ginkgolide B (GB) significantly improved cognitive function, neurodegeneration, and neuropathological changes in AD model mice. Treatment with GB reduced levels of RAGE and Bax while increasing Bcl-2 levels in AD model mice. Additionally, GB treatment reversed dysbiosis in gut microbiota by restoring the abundance of certain bacterial species.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Neuroinflammation in Alzheimer's disease and beneficial action of luteolin

Alejandro Delgado et al.

Summary: Alzheimer's disease, the most common form of dementia globally, is expected to continue to rise in prevalence in the coming decades. Despite historical research on the amyloid cascade hypothesis, recent literature emphasizes the key role of neuroinflammation, particularly microglial activation, in the pathogenesis of AD. In addition, flavonoids like luteolin in olive pomace oil combined with hydroxytyrosol show promise as a prophylactic treatment due to their beneficial effects.

BIOFACTORS (2021)

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Review Neurosciences

Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol

Rahul et al.

Summary: Kaempferol, a flavonoid compound found in various plants, has neuroprotective effects against several neurodegenerative diseases, such as Parkinson's, Alzheimer's, and Huntington's diseases. It delays the initiation and progression of these disorders by acting as a scavenger of free radicals and preserving the activity of antioxidant enzymes. Its ability to cross the Blood-Brain Barrier enhances its protective effects, making it a potential dietary supplement in preventing and treating neurodegenerative diseases.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2021)

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Review Chemistry, Medicinal

Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation

Renren Bai et al.

Summary: Inflammation is an adaptive response of the immune system to tissue malfunction, with alkaloids in plants widely distributed and possessing anti-inflammatory activities, potentially serving as candidate compounds for new anti-inflammatory drugs. Therefore, re-examining natural alkaloids with anti-inflammatory properties can offer new ideas for researchers in related fields and potential lead compounds for drug discovery.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer's Disease

Maria Jesus Friedli et al.

Summary: The neuroprotective effects of HupA on AD were summarized, focusing on its interactions with different molecular signaling avenues such as Wnt signaling, synaptic region mechanisms, amyloid precursor protein (APP) processing, amyloid-beta peptide (Aβ) accumulation, and mitochondrial protection.

MOLECULES (2021)

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Review Pharmacology & Pharmacy

The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review

Yi Cao et al.

Summary: With the aging population, hypertension has become a global health burden, and flavonoids in Chinese Herbal Medicine have been proven to have anti-hypertensive activities. However, more breakthrough studies are needed to support their clinical application for hypertension control.

PHARMACOLOGICAL RESEARCH (2021)

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Article Oncology

Naringin ameliorates memory deficits and exerts neuroprotective effects in a mouse model of Alzheimer's disease by regulating multiple metabolic pathways

Xiangdong Meng et al.

Summary: Naringin has been shown to improve cognitive, learning, and memory impairments in mice through various mechanisms, including impacting multiple signaling pathways. These research findings suggest that naringin may be a potential drug candidate for the treatment of Alzheimer's disease.

MOLECULAR MEDICINE REPORTS (2021)

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Article Plant Sciences

Rosmarinic acid and ursolic acid alleviate deficits in cognition, synaptic regulation and adult hippocampal neurogenesis in an Aβ1-42-induced mouse model of Alzheimer's disease

Fatima Javed Mirza et al.

Summary: The study demonstrated the proneurogenic effects of rosmarinic acid and ursolic acid in an A beta(1-42)-induced AD mouse model, showing protection against deficits in spatial and recognition memory and changes in anxiety. Treatment with these compounds normalized neuronal density and levels of neurogenic and synaptic markers.

PHYTOMEDICINE (2021)

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Review Chemistry, Medicinal

Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review

Vafa Baradaran Rahimi et al.

Summary: Studies have shown that Scutellaria baicalensis and its active constituents, baicalin and baicalein, have promising effects on controlling metabolic syndrome and related disorders such as obesity, hyperlipidemia, atherosclerosis, diabetes, and their subsequent complications by regulating key signaling pathways in glucose and lipid metabolism.

PHYTOTHERAPY RESEARCH (2021)

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Review Chemistry, Medicinal

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Ying Peng et al.

Summary: Curcumin, a natural compound, shows great potential in disease treatment with its significant anti-inflammatory effect. It has been proven to effectively improve symptoms of inflammatory diseases, making it a promising candidate for related disease treatments.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Review Biochemistry & Molecular Biology

Powerful anti-inflammatory action of luteolin: Potential increase with IL-38

Pio Conti et al.

Summary: Luteolin is a flavonoid that can decrease reactive oxygen species levels and inhibit inflammation. IL-1 family members and Toll-like receptor play roles in the immune system, while IL-37 and IL-38 are new cytokines that suppress inflammation. Combining luteolin with these anti-inflammatory cytokines may be beneficial in treating inflammatory diseases.

BIOFACTORS (2021)

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Review Neurosciences

Role of Natural Plant Products Against Alzheimer's Disease

Himanshi Varshney et al.

Summary: Alzheimer's Disease is a major neurodegenerative disorder with limited medication options available, but natural plant products have shown potential in reducing disease progression with fewer side effects.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2021)

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Editorial Material Biochemistry & Molecular Biology

Astrocytes

Philip Hasel et al.

CURRENT BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Neuronal Apoptosis Preventive Potential of Sophocarpine via Suppression of Aβ-Accumulation and Down-Regulation of Inflammatory Response

Xiaoting Zhu et al.

Summary: Sophocarpine prevents reduction of PC12 cell growth induced by beta-amyloid exposure via inhibition of inflammatory processes. The preventive effect of sophocarpine on beta-amyloid induced PC12 cell damage is associated with inhibition of NF-kappa B nuclear translocation, making it a potential treatment for neurological disorders like Alzheimer's disease.

DOKLADY BIOCHEMISTRY AND BIOPHYSICS (2021)

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Review Pharmacology & Pharmacy

A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease

Aihong Yang et al.

Summary: Alzheimer's disease is an age-related neurodegenerative disease characterized by memory loss and cognitive disorders. Current anti-AD drugs often fail due to low efficacy and side effects. Multi-target-directed ligand (MTDL) based on one molecule, multiple targets such as alpha-mangostin shows potential for AD therapy.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Pharmacology & Pharmacy

Role of natural products for the treatment of Alzheimer's disease

Tayebeh Noori et al.

Summary: Negative psychological and physiological consequences of neurodegenerative disorders, especially Alzheimer's disease, affect millions of people globally. Current treatments focus on symptom management, with natural products showing promise in preventing and alleviating symptoms of AD.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Food Science & Technology

Neuroprotective and anti-neuroinflammatory effects of ethanolic extract from leaves and stems of Aster glehni

Mi Kyung Lim et al.

Summary: The ethanolic extract from Aster glehni Fr. Schm. has shown therapeutic potential for Alzheimer's disease by exerting neuroprotective effects through the ERK/CREB/BDNF pathway.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Review Neurosciences

Role of JAK/STAT in the Neuroinflammation and its Association with Neurological Disorders

Mayank Jain et al.

Summary: This article mainly introduces the important role of the JAK/STAT signaling pathway in neuroinflammatory diseases, focusing on the characteristics of this pathway and the feasibility of targeting it as a neuroprotective therapy in the near future.

ANNALS OF NEUROSCIENCES (2021)

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Review Immunology

Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity

Namrita Halder et al.

Summary: Neurological and immunological signals interact to maintain homeostasis in the body. The cholinergic system plays a crucial role in neuroimmune communication, regulating immune response. Various molecules of the neuronal and non-neuronal cholinergic system interact to modulate inflammation and immunity.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Neuroinflammation in Alzheimer's Disease

Isaac G. Onyango et al.

Summary: Alzheimer's disease is a neurodegenerative disease associated with aging, with no effective treatments currently available. Inflammaging may contribute to the progression of neurodegeneration in AD.

BIOMEDICINES (2021)

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Article Pharmacology & Pharmacy

Aducanumab: First Approval

Sohita Dhillon

Summary: Aducanumab is a monoclonal antibody developed for the treatment of Alzheimer's disease, targeting aggregated forms of amyloid beta. It has received approval in the USA for use in patients with mild cognitive impairment or mild dementia. Ongoing studies are evaluating its safety and efficacy in patients with early Alzheimer's disease.

DRUGS (2021)

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Article Biochemistry & Molecular Biology

Deciphering the Potential Neuroprotective Effects of Luteolin against Aβ1-42-Induced Alzheimer's Disease

Sareer Ahmad et al.

Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Agriculture, Multidisciplinary

Evaluation of Blood-Brain Barrier Permeability of Polyphenols, Anthocyanins, and Their Metabolites

Rena Shimazu et al.

Summary: The study found that anthocyanins had difficulty crossing the blood-brain barrier into the brain, and were not directly associated with the prevention of beta-amyloid-induced neurotoxicity.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Review Cell Biology

Inflammation and Alzheimer's Disease: Mechanisms and Therapeutic Implications by Natural Products

Mashoque Ahmad Rather et al.

Summary: Alzheimer's disease is a neurodegenerative disorder with no clear causative event, making it challenging to diagnose and treat effectively. Recent research has focused on neuroinflammation as a target for therapy in order to slow down the progression of the disease.

MEDIATORS OF INFLAMMATION (2021)

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Review Chemistry, Medicinal

The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases

Thomas Efferth et al.

Summary: Artemisinin and its derivatives exhibit immunosuppressive activity by inhibiting various receptor-coupled signaling pathways, leading to the inhibition of the transcription factor NF-kappa B. They downregulate numerous downstream genes involved in immune cell differentiation, apoptosis, proliferation, signal transduction, and antioxidant stress response. Additionally, artemisinins have shown therapeutic efficacy in various inflammatory and autoimmune diseases in disease-relevant animal models.

MEDICINAL RESEARCH REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease

Teeba Athar et al.

Summary: Alzheimer's disease is a complex, multifactorial, and progressive neurodegenerative disease with currently limited treatment options. Despite global efforts to identify new therapeutic agents, only one drug has been approved by the FDA for the treatment of AD since 2003. Further research is needed to develop novel therapeutic strategies to combat this century-old disease.

MOLECULAR BIOLOGY REPORTS (2021)

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Review Biochemistry & Molecular Biology

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

Md. Habibur Rahman et al.

Summary: Natural products and their bioactive compounds derived from plants have shown therapeutic potential in treating neurodegenerative diseases such as Alzheimer's, Huntington's, and Parkinson's. However, challenges remain in clinical application due to lack of scientific support and concerns about effectiveness and patient safety. Targeting multi-mechanisms of action for neuroprotection is crucial in the treatment of NDs, with natural products emerging as potential agents for this purpose.

MOLECULES (2021)

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Review Cell Biology

The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease

Xiangyu Zhou et al.

Summary: This paper explores the potential of moderate and regular caffeine consumption from coffee and tea in reducing the risk of AD and potentially treating the disease. Further research is recommended to determine the optimal dosages, frequencies, and durations of caffeine consumption for slowing down AD progression and treating AD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Pharmacology & Pharmacy

Neuroprotective Potentials of Panax Ginseng Against Alzheimer's Disease: A Review of Preclinical and Clinical Evidences

Jing Li et al.

Summary: This review summarizes the effects and mechanisms of Panax ginseng in Alzheimer's disease, as well as its potential use in the prevention and treatment of AD.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Cell Biology

Neuroprotective Natural Products for Alzheimer's Disease

Xin Chen et al.

Summary: Natural products have attracted interest in the research community and pharmaceutical industry for their neuroprotective activity against Alzheimer's disease (AD). They target different pathological mechanisms associated with AD and their mixtures or extracts containing multiple bioactive compounds may exhibit multiple neuroprotective mechanisms, offering a potential approach for AD drug discovery.

CELLS (2021)

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Review Chemistry, Medicinal

Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes

Iris Bischoff-Kont et al.

Summary: Ginger is widely used as a medicinal plant, particularly for preventing nausea and vomiting in motion sickness, with additional anti-cancer, anti-oxidative, and anti-inflammatory properties. 6-Shogaol, derived from ginger, is a key bioactive compound with reactive properties, showing potential as an anti-inflammatory substance.

PHARMACEUTICALS (2021)

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Article Endocrinology & Metabolism

Sophocarpine Attenuates Cognitive Impairment and Promotes Neurogenesis in a Mouse Model of Alzheimer's Disease

Jian-Ya Ye et al.

Summary: The study found that sophocarpine treatment in the mouse AD model significantly improved cognitive impairment, reduced neural loss, decreased Aβ plaque deposits, enhanced neurogenesis, and inhibited inflammation markers, suggesting that sophocarpine may exert neuroprotective effects through modulation of the inflammatory pathway in APP/PS1 mice.

NEUROIMMUNOMODULATION (2021)

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Review Biochemistry & Molecular Biology

Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease

Huiqin Zhang et al.

Summary: Extracellular neuritic plaques and intracellular neurofibrillary tangles, composed of amyloid-beta and phosphorylated tau protein respectively, are hallmark proteins of Alzheimer's disease. The interactions between these proteins have been extensively studied, with A beta accelerating tau phosphorylation, tau mediating A beta toxicity, and potential synergistic effects on microglial cells and astrocytes. Understanding these interactions may lead to new interventions against Alzheimer's disease.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Correction Clinical Neurology

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches (vol 20, pg 68, 2021)

Alberto Serrano-Pozo et al.

LANCET NEUROLOGY (2021)

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Review Biochemistry & Molecular Biology

Natural Products as Potential Anti-Alzheimer Agents

Siva S. Panda et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Article Chemistry, Medicinal

Natural products and their derivatives as multifunctional ligands against Alzheimer's disease

Pooja Patil et al.

DRUG DEVELOPMENT RESEARCH (2020)

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Article Chemistry, Medicinal

Parthenolide ameliorates intracerebral hemorrhage-induced brain injury in rats

Jun-an Wang et al.

PHYTOTHERAPY RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Neuroinflammation and Neurogenesis in Alzheimer's Disease and Potential Therapeutic Approaches

Pi-Shan Sung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Chemistry, Analytical

Blood-brain barrier permeability study of ginger constituents

Alexandra Simon et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2020)

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Article Nutrition & Dietetics

Anti-Inflammatory and Antioxidant Effects of Anthocyanins of Trifolium pratense (Red Clover) in Lipopolysaccharide-Stimulated RAW-267.4 Macrophages

Sang Gil Lee et al.

NUTRIENTS (2020)

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Article Food Science & Technology

Neuroprotective and Anti-Neuroinflammatory Effects of a Poisonous Plant Croton tiglium Linn. Extract

Deepak Prasad Gupta et al.

TOXINS (2020)

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Review Biochemistry & Molecular Biology

Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer's Disease

Tomoharu Kuboyama et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Effects of Apigenin on RBL-2H3, RAW264.7, and HaCaT Cells: Anti-Allergic, Anti-Inflammatory, and Skin-Protective Activities

Che-Hwon Park et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Naringenin downregulates inflammation-mediated nitric oxide overproduction and potentiates endogenous antioxidant status during hyperglycemia

Kanwal Rehman et al.

JOURNAL OF FOOD BIOCHEMISTRY (2020)

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Article Biotechnology & Applied Microbiology

Five novel and highly efficient endophytic fungi isolated from Huperzia serrata expressing huperzine A for the treatment of Alzheimer's disease

Han Wen-Xia et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

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Review Medicine, Research & Experimental

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

Dey Parama et al.

LIFE SCIENCES (2020)

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Article Food Science & Technology

Natural Xanthone α-Mangostin Inhibits LPS-Induced Microglial Inflammatory Responses and Memory Impairment by Blocking the TAK1/NF-κB Signaling Pathway

Huifeng Guan et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Catechins as Tools to Understand the Molecular Basis of Neurodegeneration

Karla Martinez Pomier et al.

MOLECULES (2020)

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Article Biochemistry & Molecular Biology

Evaluation of Antioxidant and Anti-Inflammatory Activity of Anthocyanin-Rich Water-Soluble Aronia Dry Extracts

Mariusz Banach et al.

MOLECULES (2020)

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Article Pharmacology & Pharmacy

The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination

Monique Marylin Alves de Almeida et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Environmental Sciences

Association of Late Life Depression, (Non-) Modifiable Risk and Protective Factors with Dementia and Alzheimer's Disease: Literature Review on Current Evidences, Preventive Interventions and Possible Future Trends in Prevention and Treatment of Dementia

Chih-Yun Kuo et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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Review Immunology

Alzheimer's disease: natural products as inhibitors of neuroinflammation

Olumayokun A. Olajide et al.

INFLAMMOPHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Can We Treat Neuroinflammation in Alzheimer's Disease?

Sandra Sanchez-Sarasua et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

The Anti-Neuroinflammatory Role of Anthocyanins and Their Metabolites for the Prevention and Treatment of Brain Disorders

Joana E. Henriques et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models (2010-2020): A Review

Maria Elaine Araruna et al.

MOLECULES (2020)

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Article Medicine, Research & Experimental

Advances in Drug Therapy for Alzheimer's Disease

Chuan-cong Zhu et al.

CURRENT MEDICAL SCIENCE (2020)

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Review Biotechnology & Applied Microbiology

Natural Cinnamaldehyde and Its Derivatives Ameliorate Neuroinflammatory Pathways in Neurodegenerative Diseases

Mehrdad Hajinejad et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Review Pharmacology & Pharmacy

Alzheimer's disease: Recent treatment strategies

Miguel Vaz et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Plant Sciences

Triterpenoids and steroids isolated from Anatolian Capparis ovata and their activity on the expression of inflammatory cytokines

Isil Gazioglu et al.

PHARMACEUTICAL BIOLOGY (2020)

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Article Geriatrics & Gerontology

Artemisinin Improved Neuronal Functions in Alzheimer's Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway

Xia Zhao et al.

AGING AND DISEASE (2020)

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Review Biochemistry & Molecular Biology

Advances in chemistry and bioactivity of parthenolide

Robert R. A. Freund et al.

NATURAL PRODUCT REPORTS (2020)

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Review Cell Biology

Green tea catechins inhibit microglial activation which prevents the development of neurological disorders

Tahereh Farkhondeh et al.

NEURAL REGENERATION RESEARCH (2020)

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Review Pharmacology & Pharmacy

Drug development for Alzheimer's disease: review

Kejing Lao et al.

JOURNAL OF DRUG TARGETING (2019)

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Review Clinical Neurology

Targeting Inflammatory Pathways in Alzheimer's Disease: A Focus on Natural Products and Phytomedicines

Matthew J. Sharman et al.

CNS DRUGS (2019)

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Review Biochemistry & Molecular Biology

Flavonoids: Broad Spectrum Agents on Chronic Inflammation

Hyun Lim et al.

BIOMOLECULES & THERAPEUTICS (2019)

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Review Medical Laboratory Technology

Neuro-inflammation and anti-inflammatory treatment options for Alzheimer's disease

Tomris Ozben et al.

CLINICAL BIOCHEMISTRY (2019)

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Review Biochemistry & Molecular Biology

Natural Products in Alzheimer's Disease Therapy: Would Old Therapeutic Approaches Fix the Broken Promise of Modern Medicines?

Solomon Habtemariam

MOLECULES (2019)

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Article Multidisciplinary Sciences

Cloning and characterization of a tyrosine decarboxylase involved in the biosynthesis of galanthamine in Lycoris aurea

Rong Wang et al.

PEERJ (2019)

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Article Multidisciplinary Sciences

Rosmarinic acid suppresses Alzheimer's disease development by reducing amyloid β aggregation by increasing monoamine secretion

Tomoki Hase et al.

SCIENTIFIC REPORTS (2019)

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Article Medicine, Research & Experimental

Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis

Hai Xiao et al.

MEDICAL SCIENCE MONITOR (2019)

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Article Neurosciences

Formononetin Ameliorates Cognitive Disorder via PGC-1 alpha Pathway in Neuroinflammation Conditions in High-Fat Diet-Induced Mice

Xinxin Fu et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2019)

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Article Cell Biology

Cytotoxic and antiproliferative effects of thymoquinone on rat C6 glioma cells depend on oxidative stress

N. G. Krylova et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2019)

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Review Pharmacology & Pharmacy

Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer's and Parkinson's disease models

Si-Tong Feng et al.

PHARMACOLOGICAL RESEARCH (2019)

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Review Biochemistry & Molecular Biology

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Justin M. Long et al.

CELL (2019)

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Review Biochemistry & Molecular Biology

Microglia Biology: One Century of Evolving Concepts

Marco Prinz et al.

CELL (2019)

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Review Chemistry, Applied

Anti-inflammatory effects of flavonoids

Soheila J. Maleki et al.

FOOD CHEMISTRY (2019)

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Review Chemistry, Medicinal

Macroalgae as a Valuable Source of Naturally Occurring Bioactive Compounds for the Treatment of Alzheimer's Disease

Tosin A. Olasehinde et al.

MARINE DRUGS (2019)

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Article Multidisciplinary Sciences

Using high-throughput sequencing to explore the anti-inflammatory effects of α-mangostin

Peng Yin et al.

SCIENTIFIC REPORTS (2019)

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Article Clinical Neurology

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

Woo Shik Shin et al.

ALZHEIMERS RESEARCH & THERAPY (2019)

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Review Pharmacology & Pharmacy

Amyloid precursor protein-mediated mitochondrial regulation and Alzheimer's disease

M. Isabel G. Lopez Sanchez et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

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Review Cell Biology

Exploring the efficacy of natural products in alleviating Alzheimer's disease

Prajakta Deshpande et al.

NEURAL REGENERATION RESEARCH (2019)

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Article Biology

Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells

Chiara Porro et al.

BIOLOGY-BASEL (2019)

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Review Cell Biology

Microglia in Alzheimer's disease

David V. Hansen et al.

JOURNAL OF CELL BIOLOGY (2018)

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Review Clinical Neurology

Neuroinflammatory responses in Alzheimer's disease

Cira Dansokho et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

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Article Chemistry, Multidisciplinary

Cyanidin attenuates Aβ25-35-induced neuroinflammation by suppressing NF-κB activity downstream of TLR4/NOX4 in human neuroblastoma cells

Sarinthorn Thummayot et al.

ACTA PHARMACOLOGICA SINICA (2018)

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Article Biochemistry & Molecular Biology

NO inhibitors function as potential anti-neuroinflammatory agents for AD from the flowers of Inula japonica

Feng Liu et al.

BIOORGANIC CHEMISTRY (2018)

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Article Toxicology

Thymoquinone alleviates the experimentally induced Alzheimer's disease inflammation by modulation of TLRs signaling

Y. S. Abulfadl et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2018)

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Review Neurosciences

Role of Blood-Brain Barrier in Alzheimer's Disease

Zhiyou Cai et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Article Neurosciences

Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside

Ravikanth Velagapudi et al.

MOLECULAR NEUROBIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Optimization of the Preparation Conditions of Borneol-Modified Ginkgolide Liposomes by Response Surface Methodology and Study of Their Blood Brain Barrier Permeability

Zhiyang Lv et al.

MOLECULES (2018)

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Article Chemistry, Organic

Hupercumines A and B, Lycopodium Alkaloids from Huperzia cunninghamioides, Inhibiting Acetylcholinesterase

Yusuke Hirasawa et al.

ORGANIC LETTERS (2018)

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Article Clinical Neurology

Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment

Dunja Knezevic et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2018)

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Article Pharmacology & Pharmacy

Anti-inflammatory Effects of Curcumin in Microglial Cells

Yangyang Yu et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Pharmacology & Pharmacy

Long-term Treatment with Low-Dose Caffeine Worsens BPSD-Like Profile in 3xTg-AD Mice Model of Alzheimer's Disease and Affects Mice with Normal Aging

Raquel Baeta-Corral et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Pharmacology & Pharmacy

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease

Bushra Shal et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Immunology

Betaine in inflammation: Mechanistic Aspects and Applications

Guangfu Zhao et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Biochemistry & Molecular Biology

Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C. Cheignon et al.

REDOX BIOLOGY (2018)

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Review Neurosciences

Alzheimer's disease hypothesis and related therapies

Xiaoguang Du et al.

TRANSLATIONAL NEURODEGENERATION (2018)

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Review Biochemistry & Molecular Biology

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

Cyril Laurent et al.

BIOMEDICAL JOURNAL (2018)

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Review Food Science & Technology

A Review on the Dietary Flavonoid Tiliroside

Daniel M. Grochowski et al.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2018)

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Review Biochemistry & Molecular Biology

Effects of Tea Catechins on Alzheimer's Disease: Recent Updates and Perspectives

Kazuki Ide et al.

MOLECULES (2018)

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Article Biochemistry & Molecular Biology

Isolation of Novel Sesquiterpeniods and Anti-neuroinflammatory Metabolites from Nardostachys jatamansi

Chi-Su Yoon et al.

MOLECULES (2018)

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Review Pharmacology & Pharmacy

Naringenin as a potential immunomodulator in therapeutics

Wenfeng Zeng et al.

PHARMACOLOGICAL RESEARCH (2018)

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Article Food Science & Technology

Effects of Quercetin Intervention on Cognition Function in APP/PS1 Mice was Affected by Vitamin D Status

Menglian Lv et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2018)

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Review Cell Biology

Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1

Bruno Alexandre Quadros Gomes et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Review Immunology

Betaine Inhibits Interleukin-1 beta Production and Release: Potential Mechanisms

Yaoyao Xia et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Neuroprotective effect of formononetin in ameliorating learning and memory impairment in mouse model of Alzheimer's disease

Hong-Xin Fei et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2018)

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Review Food Science & Technology

Caffeine intake and its sources: A review of national representative studies

Joris C. Verster et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2018)

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Review Food Science & Technology

Natural antioxidant polyphenols on inflammation management: Anti-glycation activity vs metalloproteinases inhibition

Lucia Crasci et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2018)

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Article Neurosciences

Neuroinflammation pathways: a general review

Tara Shabab et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2017)

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Article Endocrinology & Metabolism

Sinomenine attenuates chronic inflammatory pain in mice

Shuo Li et al.

METABOLIC BRAIN DISEASE (2017)

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Article Neurosciences

Long-Term Mangiferin Extract Treatment Improves Central Pathology and Cognitive Deficits in APP/PS1 Mice

Carmen Infante-Garcia et al.

MOLECULAR NEUROBIOLOGY (2017)

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Article Neurosciences

Parthenolide, an NF-κB Inhibitor Ameliorates Diabetes-Induced Behavioural Deficit, Neurotransmitter Imbalance and Neuroinflammation in Type 2 Diabetes Rat Model

Pragyanshu Khare et al.

NEUROMOLECULAR MEDICINE (2017)

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Review Chemistry, Medicinal

Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents

Marie Jouanne et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

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Article Immunology

Baicalein exerts anti-neuroinflammatory effects to protect against rotenone-induced brain injury in rats

Xue Zhang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2017)

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Article Developmental Biology

Galantamine administration reduces reactive astrogliosis and upregulates the anti-oxidant enzyme catalase in rats submitted to neonatal hypoxia ischemia

F. K. Odorcyk et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2017)

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Review Agriculture, Multidisciplinary

Chemistry, Antimicrobial Mechanisms, and Antibiotic Activities of Cinnamaldehyde against Pathogenic Bacteria in Animal Feeds and Human Foods

Mendel Friedman

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

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Review Medicine, Research & Experimental

Microglia in Alzheimer's disease

Heela Sarlus et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

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Article Immunology

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease

Charbel Moussa et al.

JOURNAL OF NEUROINFLAMMATION (2017)

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Review Clinical Neurology

Astrocyte and Alzheimer's disease

Zhiyou Cai et al.

JOURNAL OF NEUROLOGY (2017)

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Review Biochemistry & Molecular Biology

An Overview of Stress-Induced Resveratrol Synthesis in Grapes: Perspectives for Resveratrol-Enriched Grape Products

Md Mohidul Hasan et al.

MOLECULES (2017)

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Review Neurosciences

The blood-brain barrier in Alzheimer's disease

Elena Zenaro et al.

NEUROBIOLOGY OF DISEASE (2017)

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Article Biochemistry & Molecular Biology

Betaine in the Brain: Characterization of Betaine Uptake, its Influence on Other Osmolytes and its Potential Role in Neuroprotection from Osmotic Stress

Leena S. Knight et al.

NEUROCHEMICAL RESEARCH (2017)

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Article Pharmacology & Pharmacy

Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation

Wenbo He et al.

PHARMACOLOGICAL REPORTS (2017)

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Article Cell Biology

The Amyloid Phenomenon and Its Links with Human Disease

Christopher M. Dobson

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

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Article Ophthalmology

Tissue Distribution of trans-Resveratrol and Its Metabolites after Oral Administration in Human Eyes

Shuaishuai Wang et al.

JOURNAL OF OPHTHALMOLOGY (2017)

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Review Pharmacology & Pharmacy

Anthocyanins: Multi-Target Agents for Prevention and Therapy of Chronic Diseases

Swathi Putta et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

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Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer's disease: A review

Yingying Jiang et al.

BIOORGANIC CHEMISTRY (2017)

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Review Chemistry, Medicinal

Alzheimer's Disease and Natural Products: Future Regimens Emerging from Nature

Md. Asiful Islam et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)

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Review Neurosciences

The neuroprotective effects of caffeine in neurodegenerative diseases

Mahshad Kolahdouzan et al.

CNS NEUROSCIENCE & THERAPEUTICS (2017)

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Article Biochemistry & Molecular Biology

Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish

Ji-Hyun Hwang et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2016)

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Review Clinical Neurology

Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research

U. Damar et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2016)

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Article Chemistry, Analytical

Validation of UHPLC-MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies

Fahimeh Moradi-Afrapoli et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2016)

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Review Chemistry, Medicinal

Berberis Vulgaris and Berberine: An Update Review

Mohsen Imenshahidi et al.

PHYTOTHERAPY RESEARCH (2016)

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Review Nutrition & Dietetics

Quercetin, Inflammation and Immunity

Yao Li et al.

NUTRIENTS (2016)

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Review Clinical Neurology

Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research

U. Damar et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2016)

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Review Cell Biology

Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease

Madhuri Venigalla et al.

NEURAL REGENERATION RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Plant alkaloids as drug leads for Alzheimer's disease

Yu Pong Ng et al.

NEUROCHEMISTRY INTERNATIONAL (2015)

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Article Psychology, Biological

Resveratrol exerts anti-inflammatory and neuroprotective effects to prevent memory deficits in rats exposed to chronic unpredictable mild stress

Yusufhan Yazir et al.

PHYSIOLOGY & BEHAVIOR (2015)

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Editorial Material Parasitology

A Brief History of Qinghaosu

Nicholas J. White et al.

TRENDS IN PARASITOLOGY (2015)

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Review Clinical Neurology

Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease

Diego Gomez-Nicola et al.

ALZHEIMERS RESEARCH & THERAPY (2015)

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Review Clinical Neurology

Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease

Dietmar Rudolf Thal et al.

ACTA NEUROPATHOLOGICA (2015)

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6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia

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