Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer's Disease

Alzheimer's disease (AD) is an age-related chronic progressive neurodegenerative disease, which is the main cause of dementia in the elderly. Much evidence shows that the onset and late symptoms of AD are caused by multiple factors. Among them, aging is the main factor in the pathogenesis of AD, and the most important risk factor for AD is neuroinflammation. So far, there is no cure for AD, but the relationship between neuroinflammation and AD may provide a new strategy for the treatment of AD. We herein discussed the main etiology hypothesis of AD and the role of neuroinflammation in AD, as well as anti-inflammatory natural products with the potential to prevent and alleviate AD symptoms, including alkaloids, steroids, terpenoids, flavonoids and polyphenols, which are available with great potential for the development of anti-AD drugs.

Automated summary

Alzheimer's disease is the main cause of dementia in the elderly and is caused by multiple factors, with aging and neuroinflammation being the main factors. While there is currently no cure for Alzheimer's disease, the relationship between neuroinflammation and the disease may provide a new strategy for treatment. Natural anti-inflammatory products, such as alkaloids, steroids, terpenoids, flavonoids, and polyphenols, show potential in preventing and alleviating symptoms of Alzheimer's disease, and can be developed into anti-AD drugs.