Structural Features of Small Molecule Antioxidants and Strategic Modifications to Improve Potential Bioactivity

This review surveys the major structural features in various groups of small molecules that are considered to be antioxidants, including natural and synthetic compounds alike. Recent advances in the strategic modification of known small molecule antioxidants are also described. The highlight is placed on changing major physicochemical parameters, including log p, bond dissociation energy, ionization potential, and others which result in improved antioxidant activity.

Automated summary

This review provides an overview of the major structural features of small molecule antioxidants, both natural and synthetic compounds. The recent advancements in modifying known antioxidants are discussed, with an emphasis on improving antioxidant activity by changing physicochemical parameters such as log p, bond dissociation energy, and ionization potential.