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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
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IMMUNITY (2017)
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The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway
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Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition
Chia-Chen Liu et al.
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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
Yang Shi et al.
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First AAV gene therapy poised for landmark approval
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Selective deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease (APP/PS1) mice by inhibiting TGF-β/Smad2/STAT3 signaling
Jin-yu Zheng et al.
NEUROBIOLOGY OF AGING (2017)
APOE genotype and early β-amyloid accumulation in older adults without dementia
Yen Ying Lim et al.
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Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis
Tien-Phat V. Huynh et al.
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ApoE4 Accelerates Early Seeding of Amyloid Pathology
Chia-Chen Liu et al.
NEURON (2017)
Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism
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Alzheimers Research & Therapy (2017)
Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke
Tian Ming Tu et al.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2017)
Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model
Daniel T. Laskowitz et al.
SCIENTIFIC REPORTS (2017)
Mechanisms of Melatonin in Alleviating Alzheimer's Disease
Mayuri Shukla et al.
CURRENT NEUROPHARMACOLOGY (2017)
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Tanya Gwendolyn Nock et al.
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miR-137 attenuates Aβ-induced neurotoxicity through inactivation of NF-κB pathway by targeting TNFAIP1 in Neuro2a cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
Hadas Keren-Shaul et al.
CELL (2017)
Apolipoprotein E2 and E3, but Not E4, Promote Retinal Pathologic Neovascularization
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2017)
Molecular genetics of early-onset Alzheimer's disease revisited
Rita Cacace et al.
ALZHEIMERS & DEMENTIA (2016)
APOE2 Eases Cognitive Decline during Aging: Clinical and Preclinical Evaluations
Mitsuru Shinohara et al.
ANNALS OF NEUROLOGY (2016)
Apolipoprotein E4 association with metabolic syndrome depends on body fatness
Elena Torres-Perez et al.
ATHEROSCLEROSIS (2016)
Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease
Dalia El-Lebedy et al.
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Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence
Yu Yamazaki et al.
CNS DRUGS (2016)
ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies
Anat Boehm-Cagan et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment
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Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma
Alaina T. Baker-Nigh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice
Courtney Lane-Donovan et al.
JOURNAL OF NEUROSCIENCE (2016)
Interactive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population
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LIPIDS IN HEALTH AND DISEASE (2016)
Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease
Robert A. Sweet et al.
MOLECULAR & CELLULAR PROTEOMICS (2016)
The antibody aducanumab reduces Aβ plaques in Alzheimer's disease
Jeff Sevigny et al.
NATURE (2016)
Relative effect of APOE ε4 on neuroimaging biomarker changes across the lifespan
Julie Gonneaud et al.
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Evidence of association between sleep quality and APOE ε4 in healthy older adults A pilot study
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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
Felix L. Yeh et al.
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Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain
Bruce Teter et al.
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Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease
Chia-Chen Liu et al.
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Jeffrey L. Cummings et al.
ALZHEIMERS RESEARCH & THERAPY (2016)
Mechanisms of Aβ Clearance and Degradation by Glial Cells
Miriam Ries et al.
FRONTIERS IN AGING NEUROSCIENCE (2016)
Melatonin for Sleep Disorders and Cognition in Dementia: A Meta-Analysis of Randomized Controlled Trials
Jing Xu et al.
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2015)
APOEε2 is associated with milder clinical and pathological Alzheimer disease
Alberto Serrano-Pozo et al.
ANNALS OF NEUROLOGY (2015)
miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo
Pascal Y. Smith et al.
HUMAN MOLECULAR GENETICS (2015)
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
Yuka Atagi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain
Jaekwang Kim et al.
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Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice
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NATURE REVIEWS NEUROLOGY (2015)
Direct intracerebral delivery of a miR-33 antisense oligonucelotide into mouse brain increases brain ABCA1 expression
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NEUROSCIENCE LETTERS (2015)
Prevalence of the Apolipoprotein E Arg145Cys Dyslipidemia At-Risk Polymorphism in African-Derived Populations
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AMERICAN JOURNAL OF CARDIOLOGY (2014)
The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation
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BIOCHEMISTRY (2014)
Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition
Gustavo A. Rodriguez et al.
JOURNAL OF NEUROINFLAMMATION (2014)
Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis
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JOURNAL OF NEUROSCIENCE (2014)
ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease
Christopher W. Medway et al.
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ApoE and Aβ in Alzheimer's Disease: Accidental Encounters or Partners?
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NEURON (2014)
Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration
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AMERICAN JOURNAL OF PATHOLOGY (2013)
Molecular Mechanisms Responsible for the Differential Effects of ApoE3 and ApoE4 on Plasma Lipoprotein-Cholesterol Levels
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)
Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased with APOE4 and Alzheimer Disease in a Transgenic Mouse Model and Human Samples
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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature
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Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1
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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
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NATURE REVIEWS NEUROLOGY (2013)
Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth
Kelly R. Murphy et al.
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ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
Philip B. Verghese et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain
Eloise Hudry et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Evidence for impaired amyloid beta clearance in Alzheimer's disease
Kristin R. Wildsmith et al.
ALZHEIMERS RESEARCH & THERAPY (2013)
Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease
Holly D. Soares et al.
ARCHIVES OF NEUROLOGY (2012)
Disturbed Sleep Patterns in Elders with Mild Cognitive Impairment: The Role of Memory Decline and ApoE ε4 Genotype
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Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
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JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid β Peptide
Tadafumi Hashimoto et al.
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Liver X receptors regulate cholesterol homeostasis in oligodendrocytes
Katherine Nelissen et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2012)
APOE modifies the association between A beta load and cognition in cognitively normal older adults
K. Kantarci et al.
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Apolipoprotein E Sets the Stage: Response to Injury Triggers Neuropathology
Robert W. Mahley et al.
NEURON (2012)
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Paige E. Cramer et al.
SCIENCE (2012)
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup
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Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Apolipoprotein E and Peptide Mimetics Modulate Inflammation by Binding the SET Protein and Activating Protein Phosphatase 2A
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Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis
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JOURNAL OF NEUROSCIENCE (2011)
Reduced levels of human apoE4 protein in an animal model of cognitive impairment
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NEUROBIOLOGY OF AGING (2011)
C-Reactive Protein and Genetic Variants and Cognitive Decline in Old Age: The PROSPER Study
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PLOS ONE (2011)
Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions
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Neuropathological Alterations in Alzheimer Disease
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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)
APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-beta(42) in APOE Knock-in and Knock-out Mice
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Attention deficits in Alzheimer's disease and vascular dementia
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Pericytes regulate the blood-brain barrier
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NATURE (2010)
Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking
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PLOS ONE (2010)
Apolipoprotein E-Dependent Accumulation of Alzheimer Disease-Related Lesions Begins in Middle Age
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ANNALS OF NEUROLOGY (2009)
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
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JOURNAL OF LIPID RESEARCH (2009)
Human APOE Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
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JOURNAL OF NEUROSCIENCE (2009)
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
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NATURE REVIEWS NEUROSCIENCE (2009)
Apolipoprotein E ε4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Role of the N- and C-terminal domains in binding of apolipoprotein E isoforms to heparan sulfate and dermatan sulfate: A surface plasmon resonance study
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BIOCHEMISTRY (2008)
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BIOLOGICAL PSYCHOLOGY (2008)
ApoE promotes the proteolytic degradation of Aβ
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NEUROLOGIC CLINICS (2007)
Blocking the apolipoprotein E/amyloid-β interaction as a potential therapeutic approach for Alzheimer's disease
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils
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Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells
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JOURNAL OF NEUROCHEMISTRY (2006)
Premorbid effects of APOE on synaptic proteins in human temporal neocortex
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NEUROBIOLOGY OF AGING (2006)
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Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia
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MOVEMENT DISORDERS (2006)
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The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor
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JOURNAL OF LIPID RESEARCH (2005)
Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase - Modulation by zinc
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Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction
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STROKE (2003)
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Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Aβ peptide
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BIOCHEMISTRY (2001)
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FEBS LETTERS (2000)
Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture
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JOURNAL OF NEUROCHEMISTRY (2000)
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