Apelin-13 facilitates mitochondria homeostasis via mitophagy to prevent against airway oxidative injury in asthma

Article Agriculture, Multidisciplinary

Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis

Qiaoyun Bai et al.

Summary: Sesamin, a natural lignan, may relieve asthma airway inflammation by inhibiting mitochondrial apoptosis and mitophagy.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2022)

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Article Neurosciences

Apelin-13 facilitates lordosis behavior following infusions to the ventromedial hypothalamus or preoptic area in ovariectomized, estrogen-primed rats

Marcos Garcia-Juarez et al.

Summary: This study investigated the effect of apelin-13 on different brain areas at varying doses, and found that it can induce lordosis behavior, with a more pronounced effect in the VMH of EB-primed rats, and only the 0.75 μg infusion of apelin in the POA induced significant lordosis at 120 and 240 min.

NEUROSCIENCE LETTERS (2022)

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Article Allergy

CaMKII oxidation regulates cockroach allergen-induced mitophagy in asthma

Yan Zhang et al.

Summary: The study identified that cockroach allergen activates autophagy, while inhibition of autophagy can mitigate airway hyperresponsiveness and oxidative stress induced by allergic airway inflammation. Furthermore, the research revealed a pathological feedforward circuit between cockroach allergen-induced ROS and autophagy.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Mitochondrial dynamics and mitophagy in lung disorders

Archana Sharma et al.

Summary: Mitochondria play crucial roles in biosynthesis, bioenergetics, and signaling within cells. Dysfunctions in mitochondrial dynamics may contribute to the onset and progression of lung disorders. Understanding the multifaceted regulations of mitochondrial dynamics and mitophagy could aid in the development of potential therapies for these diseases.

LIFE SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Apelin-13 induces mitophagy in bone marrow mesenchymal stem cells to suppress intracellular oxidative stress and ameliorate osteoporosis by activation of AMPK signaling pathway

Liang Chen et al.

Summary: Apelin plays a crucial role in regulating bone metabolism and mitigating the effects of osteoporosis. Through activation of mitophagy, Apelin-13 treatment was able to improve bone health and function in both in vitro and in vivo models of osteoporosis, suggesting its potential as a therapeutic target for osteoporosis.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Allergy

Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma

Briana N. James et al.

Summary: Elevation of ceramide levels after allergen challenge contributes to features of severe asthma, including apoptosis, reactive oxygen species generation, and neutrophilic infiltrate. Ceramide may be a potential biomarker for monitoring disease progression and optimizing clinical outcomes in severe asthma patients.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Mitophagy and Oxidative Stress: The Role of Aging

Anna De Gaetano et al.

Summary: Mitochondrial dysfunction is a key characteristic of aging, with mitophagy playing a crucial role in eliminating damaged mitochondria. Oxidative stress is a major factor in aging, triggering mitophagy to remove dysfunctional mitochondria. However, chronic oxidative stress can lead to mitochondrial damage that overwhelms the autophagic pathways, disrupting the delicate balance between mitophagy, ROS production, and mitochondrial damage, which can accelerate the aging process.

ANTIOXIDANTS (2021)

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Article Cell Biology

Hypoxic postconditioning promotes mitophagy against transient global cerebral ischemia via PINK1/Parkin-induced mitochondrial ubiquitination in adult rats

Haixia Wen et al.

Summary: The study showed that hypoxic postconditioning (HPC) exerts neuroprotection against transient global cerebral ischemia (tGCI) by promoting mitophagy mediated by the PINK1/Parkin-dependent pathway in the hippocampal CA1 subregion. This novel finding provides a new perspective on neuroprotection mechanisms against cerebral ischemia.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury

Zi-Qi Shao et al.

Summary: Apelin-13 has neuroprotective effects against cerebral ischemia/reperfusion injury by regulating apoptosis and autophagy processes, through increasing Bcl-2/Bax ratio, reducing cleaved caspase-3 expression, modulating LC3B, p62, and Beclinl expression, and activating the PI3K/Akt/mTOR pathway. Its effects are mediated by Bcl-2 upregulation and mTOR signaling pathway activation.

NEURAL REGENERATION RESEARCH (2021)

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Review Biochemistry & Molecular Biology