CDT1, a licensing factor that limits rereplication

Cells must avoid licensing of neosynthesized DNA to prevent rereplication. In this issue of Molecular Cell, Ratnayeke et al. (2022)(1) reveal how the licensing factor CDT1, prior to its degradation, inhibits DNA elongation by suppressing CMG helicase progression at replication forks.

Automated summary

Cells prevent rereplication by avoiding licensing of neosynthesized DNA. In this study published in Molecular Cell, Ratnayeke et al. (2022)(1) demonstrate that the licensing factor CDT1 inhibits CMG helicase progression at replication forks by suppressing DNA elongation before its degradation.