4.5 Article

In vitro phenotypic effects of Lipoxin A4 on M1 and M2 polarized macrophages derived from THP-1

Related references

Note: Only part of the references are listed.
Article Immunology

Lipoxin A4 regulates M1/M2 macrophage polarization via FPR2-IRF pathway

Jixiang Yuan et al.

Summary: LXA4 regulates macrophage polarization by modulating the FPR2-IRF pathway, inhibiting inflammatory polarization of M1 macrophages and promoting IL-4-induced polarization of M2 macrophages.

INFLAMMOPHARMACOLOGY (2022)

Review Chemistry, Medicinal

Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential

Monika Maciuszek et al.

Summary: FPR2/ALX plays a crucial role in maintaining host defense and orchestrating the inflammatory process by responding to various agonists. These agonists include lipids, proteins, peptides, and synthetic small molecule agonists, which promote resolution and tissue regeneration during inflammation.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Immunology

Resolution-Based Therapies: The Potential of Lipoxins to Treat Human Diseases

Rafael I. Jaen et al.

Summary: Inflammation is a physiological response to injury, but excessive inflammation can lead to chronic inflammation and fibrosis. Specialized pro-resolving mediators (SPMs) such as lipoxins are considered to have therapeutic potential for inflammatory diseases. Increasing endogenously generated lipoxins may emerge as a new therapeutic approach for preventing and treating many diseases associated with an increased inflammatory response.

FRONTIERS IN IMMUNOLOGY (2021)

Article Dentistry, Oral Surgery & Medicine

Lipoxin suppresses inflammation via the TLR4/MyD88/NF-κB pathway in periodontal ligament cells

Muhanad Ali et al.

ORAL DISEASES (2020)

Article Orthopedics

Macrophages regulate the progression of osteoarthritis

H. Zhang et al.

OSTEOARTHRITIS AND CARTILAGE (2020)

Article Multidisciplinary Sciences

Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling

Youwen Zhuang et al.

NATURE COMMUNICATIONS (2020)

Article Dentistry, Oral Surgery & Medicine

A Novel Thermoresponsive Gel as a Potential Delivery System for Lipoxin

B. Wang et al.

JOURNAL OF DENTAL RESEARCH (2019)

Article Multidisciplinary Sciences

Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2

A. Gaudin et al.

SCIENTIFIC REPORTS (2018)

Review Immunology

Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?

Luca Parisi et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

Article Immunology

Macrophages in inflammation, repair and regeneration

Yumiko Oishi et al.

INTERNATIONAL IMMUNOLOGY (2018)

Review Oncology

Recent progress on nanoparticle-based drug delivery systems for cancer therapy

Yanru Xin et al.

CANCER BIOLOGY & MEDICINE (2017)

Article Multidisciplinary Sciences

Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid

Carlos A. Sorgi et al.

SCIENTIFIC REPORTS (2017)

Article Dentistry, Oral Surgery & Medicine

Enhanced Activity of the Macrophage M1/M2 Phenotypes and Phenotypic Switch to M1 in Periodontal Infection

Ting Yu et al.

JOURNAL OF PERIODONTOLOGY (2016)

Review Immunology

Specialized pro-resolving mediators: endogenous regulators of infection and inflammation

Maria C. Basil et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Letter Dermatology

Confocal Imaging-Guided Laser Ablation of Basal Cell Carcinomas: An Ex Vivo Study

Heidy Sierra et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)

Article Cell Biology

Inflammation activation and resolution in human tendon disease

Stephanie G. Dakin et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Review Immunology

The resolution of inflammation: Principles and challenges

Sarah E. Headland et al.

SEMINARS IN IMMUNOLOGY (2015)

Article Medical Laboratory Technology

Lipoxins exert antiangiogenic and anti-inflammatory effects on Kaposi's sarcoma cells

Alexandru Marginean et al.

TRANSLATIONAL RESEARCH (2015)

Article Multidisciplinary Sciences

Novel Markers to Delineate Murine M1 and M2 Macrophages

Kyle A. Jablonski et al.

PLOS ONE (2015)

Review Immunology

Lipoxins: nature's way to resolve inflammation

Jayashree A. Chandrasekharan et al.

JOURNAL OF INFLAMMATION RESEARCH (2015)

Review Biochemistry & Molecular Biology

Distinct Signaling Cascades Elicited by Different Formyl Peptide Receptor 2 (FPR2) Agonists

Fabio Cattaneo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Oncology

Macrophage plasticity and polarization in tissue repair and remodelling

Alberto Mantovani et al.

JOURNAL OF PATHOLOGY (2013)

Article Immunology

The resolution of inflammation

Christopher D. Buckley et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Review Biochemistry & Molecular Biology

Specialized pro-resolving lipid mediators in the inflammatory response: An update

Gerard Bannenberg et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2010)

Article Biochemistry & Molecular Biology

Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways

P. Prieto et al.

CELL DEATH AND DIFFERENTIATION (2010)

Review Medicine, Research & Experimental

Leukocyte-endothelial cell interactions in the inflammatory response

WA Muller

LABORATORY INVESTIGATION (2002)