☆ 4.5 Review

Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective

MOLECULAR BIOLOGY REPORTS (2023)

Related references

Note: Only part of the references are listed.

Article Microbiology

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage

Alba Escalera et al.

Summary: This study characterized the spike polymorphisms of the emerging SARS-CoV-2 variants and investigated their impact on transmissibility and virus pathogenicity. The findings showed that specific substitutions enhance viral replication and spike protein cleavage, leading to increased transmission efficiency in infection models and human airway systems.

CELL HOST & MICROBE (2022)

Add to Collection

Review Virology

The variants of SARS-CoV-2 and the challenges of vaccines

Xiucui Han et al.

Summary: The COVID-19 pandemic has caused severe losses worldwide, leading to a focus on vaccine development. The discovery of new virus variants has posed challenges to vaccine effectiveness, but utilizing vaccines effectively remains crucial in epidemic prevention and control.

JOURNAL OF MEDICAL VIROLOGY (2022)

Add to Collection

Review Cell Biology

Mechanisms of SARS-CoV-2 entry into cells

Cody B. Jackson et al.

Summary: The entry of SARS-CoV-2 into host cells is facilitated by the interaction between the viral spike protein and ACE2, leading to virus-cell membrane fusion, which has been extensively studied at the structural and cellular levels worldwide. This understanding has paved the way for the development of effective vaccines in response to the COVID-19 pandemic, caused by the infection with SARS-CoV-2.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Add to Collection

Article Cell Biology

Cryptococcal Protease(s) and the Activation of SARS-CoV-2 Spike (S) Protein

Nozethu Mjokane et al.

Summary: This study reports the possibility of cryptococcal protease(s) activating the SARS-CoV-2 spike protein. The efficiency of cryptococcal protease(s) in processing the S1/S2 site is comparable to furin.

CELLS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Principles of SARS-CoV-2 glycosylation

Himanshi Chawla et al.

Summary: Research has shown that the structure and post-translational processing of the SARS-CoV-2 spike glycoprotein are closely associated with the function of the virus and the efficacy of sterilizing vaccines. The study suggests that glycans play an important role in the immunogen structure and efficacy.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2022)

Add to Collection

Article Chemistry, Physical

Binding Interactions between Receptor-Binding Domain of Spike Protein and Human Angiotensin Converting Enzyme-2 in Omicron Variant

Bahaa Jawad et al.

Summary: The emergence of the new SARS-CoV-2 Omicron variant has worsened the COVID-19 pandemic due to its large number of mutations, particularly in the receptor-binding domain (RBD), making it highly contagious and/or resistant to vaccines. Through molecular dynamics simulations, it has been found that the Omicron variant's RBD binds to ACE2 more efficiently and tightly, resulting in increased infectivity and transmissibility compared to other strains. Some of the RBD mutations have been predicted to affect antibody neutralization either through conformational changes in the spike protein or by altering its surface charge distribution. Other mutations either decrease or increase ACE2 binding.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

A Vaccine of SARS-CoV-2 S Protein RBD Induces Protective Immunity

Qiaoqiao Qu et al.

Summary: The fusion of RBD protein and 6HB has successfully produced a purified protein named RBD-6HB, which when combined with AL/CpG adjuvant can stimulate animals to produce high-level antibodies and establish an effective protective barrier against challenges. This highlights the importance of trimerized SARS-CoV-2 S protein RBD in designing vaccines and provides a rationale for developing a protective vaccine through the induction of antibodies against the RBD domain.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Letter Biochemistry & Molecular Biology

SARS-CoV-2 spike L452R mutation increases Omicron variant fusogenicity and infectivity as well as host glycolysis

Yanan Zhang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Structural biology of SARS-CoV-2: open the door for novel therapies

Weizhu Yan et al.

Summary: SARS-CoV-2 is the causative agent of COVID-19 and understanding the structures of its proteins and potential therapy agents is crucial for prevention and treatment of viral infections.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Add to Collection

Review Virology

Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design

Xuhua Xia

Summary: This article delves into the structure and function of the spike protein in SARS-CoV-2, aiming to enhance the mechanistic understanding of how it mediates cell entry and transmission, as well as discussing important issues related to vaccine development and the emergence of viral variants.

VIRUSES-BASEL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Structural genetics of circulating variants affecting the SARS-CoV-2 spike/human ACE2 complex

Francesco Ortuso et al.

Summary: Entry of SARS-CoV-2 into human cells is mediated by the interaction between the viral Spike protein and the human ACE2 receptor. Variants of the Spike protein may affect affinity with ACE2.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Add to Collection

Article Biophysics

The flexibility of ACE2 in the context of SARS-CoV-2 infection

Emilia P. Barros et al.

Summary: The COVID-19 pandemic has caused significant loss of life worldwide, and there are still unanswered questions regarding the viral association to ACE2 receptor. Molecular dynamics simulations reveal the flexibility of the ACE2 receptor and its dynamics on the cell surface, which could provide insights for the development of therapeutics against SARS-CoV-2.

BIOPHYSICAL JOURNAL (2021)

Add to Collection

Article Cell Biology

Higher infectivity of the SARS-CoV-2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data

Abbas Khan et al.

Summary: The new variants of SARS-CoV-2 are more contagious and require further investigation on their interaction with the host receptor to identify new therapeutic options. Specific mutations in the Spike glycoprotein of the new variants may play a critical role in their unique pathogenicity.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased Transmissibility

Hin Hark Gan et al.

Summary: The study reveals that new variants of the SARS-CoV-2 Spike protein show enhanced binding affinity to the human ACE2 receptor, potentially increasing transmissibility. Structural analysis predicts variant combinations with both enhanced affinity and antibody resistance, highlighting the complexity of viral evolution and potential impact on intervention strategies.

JOURNAL OF MOLECULAR BIOLOGY (2021)

Add to Collection

Article Microbiology

SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

Chihiro Motozono et al.

Summary: Research has shown that certain mutations in SARS-CoV-2 variants can escape HLA-restricted cellular immunity, increase affinity for host cells, promote viral replication, and potentially affect the evolution of viral phenotypes.

CELL HOST & MICROBE (2021)

Add to Collection

Article Immunology

A Computational Approach to Evaluate the Combined Effect of SARS-CoV-2 RBD Mutations and ACE2 Receptor Genetic Variants on Infectivity: The COVID-19 Host-Pathogen Nexus

Dana Ashoor et al.

Summary: Understanding SARS-CoV-2 infectivity involves studying the interactions between the virus Spike protein and the ACE2 receptor, impacted by RBD mutations and ACE2 polymorphism. Analysis shows that the majority of RBD point mutations destabilize the virus-receptor complex and different ACE2 variants lead to varying molecular interaction patterns and complex stability. Considering both ACE2 variants and SARS-CoV-2 RBD mutations is crucial for evaluating the stability of the virus-receptor association and infectivity.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Add to Collection

Article Microbiology

SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India

Sarah Cherian et al.

Summary: Genomic epidemiology and whole genome sequencing were used to investigate the transmission and evolution of the SARS-CoV-2 virus during the global pandemic. The study identified new variants B.1.617.1 and B.1.617.2 in India, responsible for the second wave of COVID-19 in Maharashtra, with B.1.617.2 designated as a VOC delta and B.1.617.1 as a variant of interest kappa. Monitoring of these and emerging variants in India is crucial for public health.

MICROORGANISMS (2021)

Add to Collection

Letter Immunology

Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19

Daniele Focosi et al.

Summary: This report demonstrates a novel mutation, Q493R, of the SARS-CoV-2 spike protein that confers resistance to both bamlanivimab and etesivimab, isolated from a patient who had received treatment with these drugs.

EMERGING INFECTIOUS DISEASES (2021)

Add to Collection

Article Chemistry, Physical

Mechanistic insights into the effects of key mutations on SARS-CoV-2 RBD-ACE2 binding

Abhishek Aggarwal et al.

Summary: Through molecular dynamics simulations and free energy calculations, this study found that the double and triple mutated variants of SARS-CoV-2 have higher binding affinities to the human ACE2 receptor compared to the wild type and N501Y variant, potentially contributing to the increased transmissibility of recent variants.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2021)

Add to Collection

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan et al.

SCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

Add to Collection

Article Pharmacology & Pharmacy

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furinlike cleavage site absent in CoV of the same clade

B. Coutard et al.

ANTIVIRAL RESEARCH (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

Add to Collection

Review Cardiac & Cardiovascular Systems

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System Celebrating the 20th Anniversary of the Discovery of ACE2

Mahmoud Gheblawi et al.

CIRCULATION RESEARCH (2020)

Add to Collection

Article Multidisciplinary Sciences

Site-specific glycan analysis of the SARS-CoV-2 spike

Yasunori Watanabe et al.

SCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Structural basis of receptor recognition by SARS-CoV-2

Jian Shang et al.

NATURE (2020)

Add to Collection

Article Immunology

ACE2, Much More Than Just a Receptor for SARS-COV-2

Lobelia Samavati et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Proteolytic Cleavage of the SARS-CoV-2 Spike Protein and the Role of the Novel S1/S2 Site

Javier A. Jaimes et al.

ISCIENCE (2020)

Add to Collection

Article Multidisciplinary Sciences

The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV

Mihkel Oerd et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Article Microbiology

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains

Tongqing Zhou et al.

CELL HOST & MICROBE (2020)

Add to Collection

Article Multidisciplinary Sciences

Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides

Geoffrey Masuyer et al.

SCIENTIFIC REPORTS (2012)

Add to Collection

Article Biochemical Research Methods

COCOMAPS: a web application to analyze and visualize contacts at the interface of biomolecular complexes

Anna Vangone et al.

BIOINFORMATICS (2011)

Add to Collection

Article Multidisciplinary Sciences

A redox switch in angiotensinogen modulates angiotensin release

Aiwu Zhou et al.

NATURE (2010)

Add to Collection

Article Psychology, Biological

The renin angiotensin system and the metabolic syndrome

Annette D. de Kloet et al.

PHYSIOLOGY & BEHAVIOR (2010)

Add to Collection

Article Multidisciplinary Sciences

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

WH Li et al.

NATURE (2003)

Add to Collection

Article Biochemistry & Molecular Biology

Comparison of the solution structures of angiotensin I & II - Implication for structure-function relationship

GA Spyroulias et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.