The role of histone methylation in renal cell cancer: an update

Renal cell carcinoma accounts for 2-3% of all cancers. It is difficult to diagnose early. Recently, genome-wide studies have identified that histone methylation was one of the functional classes that is most frequently dysregulated in renal cell cancer. Mutation or mis-regulation of histone methylation, methyltransferases, demethylases are associated with gene expression and tumor progression in renal cell cancer. Herein, we summarize histone methylations, demethylases and their alterations and mechanisms in renal cell cancer.

Automated summary

Renal cell carcinoma, accounting for 2-3% of all cancers, is challenging to diagnose early. Recent genome-wide studies have found that histone methylation is commonly dysregulated in renal cell cancer. Mutations or dysregulation of histone methylation, methyltransferases, and demethylases are associated with gene expression and tumor progression in renal cell cancer.