4.6 Review

Viral proteases as therapeutic targets

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CELL REPORTS (2021)

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Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors

Dario Akaberi et al.

Summary: A novel protease inhibitor against TBEV was discovered, providing valuable information for the development of drugs against TBEV and other flaviviruses.

ANTIVIRAL RESEARCH (2021)

Review Chemistry, Medicinal

Amino Acid and Peptide-Based Antiviral Agents

Andrzej S. Skwarecki et al.

Summary: Amino acids play a significant role in the composition of many antiviral agents, with some drugs contributing to a significant decrease in mortality from AIDS and hepatitis. The discovery of new antiviral agents and the development of existing drugs remain important, with amino acids serving as key building blocks in this process.

CHEMMEDCHEM (2021)

Article Critical Care Medicine

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial

Yaseen M. Arabi et al.

Summary: Among critically ill patients with COVID-19, lopinavir-ritonavir, hydroxychloroquine, or combination therapy worsened outcomes compared to no antiviral therapy.

INTENSIVE CARE MEDICINE (2021)

Article Biochemistry & Molecular Biology

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

Florian Kabinger et al.

Summary: Molnupiravir is an oral antiviral drug candidate that increases viral RNA mutations frequency and inhibits replication of SARS-CoV-2 by altering the substrate preference of RdRp. This two-step mutagenesis mechanism can explain the broad-spectrum antiviral activity of molnupiravir, making it a promising COVID-19 treatment option.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Article Multidisciplinary Sciences

Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies

Lee A. Armstrong et al.

Summary: Among the 16 non-structural proteins encoded by SARS CoV-2, Nsp3 is the largest and plays important roles in the viral life cycle. The papain-like protease domain (PLpro) encoded within Nsp3 cleaves viral polypeptide, as well as ubiquitin and ISG15 from host cell proteins. Screening clinical compounds, five were found to inhibit PLpro but showed no significant antiviral activity in cellular SARS-CoV-2 infection assays, highlighting the importance of alternative methods like engineered nanobodies to block PLpro activity.

PLOS ONE (2021)

Article Multidisciplinary Sciences

Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme

Chang Liu et al.

Summary: This study highlights the crucial role of ExoN in the coronavirus life cycle, its recognition and excision of nucleotide analog inhibitors, and provides insight into the molecular mechanisms of mismatch correction during coronavirus RNA synthesis. The cryo-electron microscopy structures reveal the molecular determinants of ExoN substrate specificity, offering guidance for the rational design of improved anticoronavirus therapies.

SCIENCE (2021)

Article Microbiology

HIV-1 Genomes Are Enriched in Memory CD4+ T-Cells with Short Half-Lives

Vincent Morcilla et al.

Summary: The study found that shorter cellular half-lives and proliferative potential contribute to the persistence and expansion of genetically-intact HIV-1 within different T-cell subsets, shedding light on the mechanisms maintaining the latent HIV-1 reservoir.
Article Chemistry, Multidisciplinary

In-silico drug repurposing study: Amprenavir, enalaprilat, and plerixafor, potential drugs for destabilizing the SARS-CoV-2 S-protein-angiotensin-converting enzyme 2 complex

Ivonne Buitron-Gonzalez et al.

Summary: This study identified three potential drug candidates that can destabilize the interaction between the spike protein of SARS-CoV-2 and ACE2. Molecular dynamics simulations showed that these drugs decrease the binding energy of the spike protein, which may prevent the virus from entering the cell. Plerixafor was found to have the greatest potential in destabilizing the spike protein-ACE2 complex, followed by amprenavir and enalaprilat, making them promising candidates for further in vitro and in vivo evaluations.

RESULTS IN CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Novel dynamic residue network analysis approaches to study allosteric modulation: SARS-CoV-2 Mpro and its evolutionary mutations as a case study

Olivier Sheik Amamuddy et al.

Summary: This study investigates the rational search for allosteric modulators and their mechanisms in the presence of mutations. By establishing novel computational methods, SARS-CoV-2 main protease was studied as a case. The results reveal an important residue communication path connecting the allosteric binding site to the active site, and also highlight the potential loss of allosteric communication path due to mutations.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

Article Chemistry, Multidisciplinary

Discovery of SARS-CoV-2 main protease inhibitors using a synthesis-directed de novo design model

Aaron Morris et al.

Summary: The research team used machine learning for novel compound design and synthesis route prediction, successfully identifying chemical scaffolds with antiviral activity. These findings are significant for the development of patent-free antiviral drugs.

CHEMICAL COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Repurposing the HCV NS3-4A protease drug boceprevir as COVID-19 therapeutics

Rick Oerlemans et al.

Summary: The rapid growth of COVID-19 cases leads to increasing deaths and economic paralysis. Drug repurposing is a potential short-term solution, while vaccination is a middle-term solution. Research suggests that the HCV drug boceprevir may be repurposed for COVID-19 and other coronaviral infections.

RSC MEDICINAL CHEMISTRY (2021)

Review Immunology

A review: Mechanism of action of antiviral drugs

Shamaila Kausar et al.

Summary: Antiviral drugs are a class of medicines used to treat viral infections, with strategies focusing on targeting the viruses themselves or host cell factors. Viruses can cause various serious diseases in humans, animals, and plants, and the action mechanism of antiviral drugs includes inhibiting viral nucleic acid synthesis and enhancing cell resistance to viruses.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2021)

Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Accessory mutations balance the marginal stability of the HIV-1 protease in drug resistance

Thomas R. Weikl et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2020)

Editorial Material Infectious Diseases

The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China

David S. Hui et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

Article Multidisciplinary Sciences

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

Emmie de Wit et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Virology

The emergence of SARS, MERS and novel SARS-2 coronaviruses in the 21st century

Vivaldo Gomes da Costa et al.

ARCHIVES OF VIROLOGY (2020)

Article Medical Laboratory Technology

Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

Mart Toots et al.

TRANSLATIONAL RESEARCH (2020)

Article Biology

SARS-CoV-2 (COVID-19) by the numbers

Yinon M. Bar-On et al.

ELIFE (2020)

Review Immunology

Seasonal and pandemic influenza: 100 years of progress, still much to learn

Jake Dunning et al.

MUCOSAL IMMUNOLOGY (2020)

Review Microbiology

The continued threat of emerging flaviviruses

Theodore C. Pierson et al.

NATURE MICROBIOLOGY (2020)

Article Multidisciplinary Sciences

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

Zhenming Jin et al.

NATURE (2020)

Article Medicine, General & Internal

A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19

B. Cao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Chemistry, Multidisciplinary

Allosteric Inhibition of the SARS-CoV-2 Main Protease: Insights from Mass Spectrometry Based Assays

Tarick J. El-Baba et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Biochemistry & Molecular Biology

The GABA(B)Receptor-Structure, Ligand Binding and Drug Development

Linn Samira Mari Evenseth et al.

MOLECULES (2020)

Article Multidisciplinary Sciences

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

Brandi N. Williamson et al.

NATURE (2020)

Article Multidisciplinary Sciences

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

Donghyuk Shin et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Theresa Klemm et al.

EMBO JOURNAL (2020)

Review Chemistry, Medicinal

Danoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy

Miao Miao et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2020)

News Item Multidisciplinary Sciences

MAKING SENSE OF CORONAVIRUS MUTATIONS

Ewen Callaway

NATURE (2020)

Review Pharmacology & Pharmacy

Drug repurposing approach to fight COVID-19

Thakur Uttam Singh et al.

PHARMACOLOGICAL REPORTS (2020)

Article Multidisciplinary Sciences

Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease

Lifeng Fu et al.

NATURE COMMUNICATIONS (2020)

Review Immunology

Viral Emerging Diseases: Challenges in Developing Vaccination Strategies

Maria Trovato et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Biochemical Research Methods

Evolution of drug resistance in HIV protease

Dhara Shah et al.

BMC BIOINFORMATICS (2020)

Article Multidisciplinary Sciences

CRISPR based editing of SIV proviral DNA in ART treated non-human primates

Pietro Mancuso et al.

NATURE COMMUNICATIONS (2020)

Review Toxicology

Inhibition and induction of CYP enzymes in humans: an update

Jukka Hakkola et al.

ARCHIVES OF TOXICOLOGY (2020)

Article Chemistry, Medicinal

Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®

James G. Taylor et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Review Biochemistry & Molecular Biology

Exploiting the unique features of Zika and Dengue proteases for inhibitor design

Tatana Majerova et al.

BIOCHIMIE (2019)

Review Genetics & Heredity

The remarkable history of the hepatitis C virus

Stanislas Pol et al.

GENES AND IMMUNITY (2019)

Article Multidisciplinary Sciences

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Prasanta K. Dash et al.

NATURE COMMUNICATIONS (2019)

Review Chemistry, Medicinal

Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C: design, development, and place in therapy

Thomas G. Cotter et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2019)

Review Chemistry, Medicinal

Virtual Screening Techniques in Drug Discovery: Review and Recent Applications

Sheisi F. L. da Silva Rocha et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2019)

Article Pharmacology & Pharmacy

Sofosbuvir susceptibility of genotype 1 to 6 HCV from DAA-naive subjects

Bin Han et al.

ANTIVIRAL RESEARCH (2019)

Article Microbiology

Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C virus infection

Federico J. Mensa et al.

FUTURE MICROBIOLOGY (2019)

Review Microbiology

Prisoners of war - host adaptation and its constraints on virus evolution

Peter Simmonds et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Review Immunology

Current and future priorities for the development of optimal HIV drugs

Marco Vitoria et al.

CURRENT OPINION IN HIV AND AIDS (2019)

Article Multidisciplinary Sciences

Targeting HIV-1 Protease Autoprocessing for High-throughput Drug Discovery and Drug Resistance Assessment

Liangqun Huang et al.

SCIENTIFIC REPORTS (2019)

Article Pharmacology & Pharmacy

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

Jian Lei et al.

ANTIVIRAL RESEARCH (2018)

Review Pharmacology & Pharmacy

Hepatitis C virus drug resistance associated substitutions and their clinical relevance: Update 2018

Maria C. Sorbo et al.

DRUG RESISTANCE UPDATES (2018)

Review Pharmacology & Pharmacy

Sofosbuvir/Velpatasvir/Voxilaprevir: A Review in Chronic Hepatitis C

Young-A Heo et al.

DRUGS (2018)

Article Gastroenterology & Hepatology

Treatment of hepatitis C: Results in real life

Christophe Hezode

LIVER INTERNATIONAL (2018)

Article Pharmacology & Pharmacy

Danoprevir: First Global Approval

Anthony Markham et al.

DRUGS (2018)

Article Cardiac & Cardiovascular Systems

Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure

Raza M. Alvi et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Article Multidisciplinary Sciences

Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus

David A. Constant et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Inhibition of the precursor and mature forms of HIV-1 protease as a tool for drug evaluation

Jana Humpolickova et al.

SCIENTIFIC REPORTS (2018)

Article Biochemical Research Methods

Analysis of drug resistance in HIV protease

Shrikant D. Pawar et al.

BMC BIOINFORMATICS (2018)

Article Chemistry, Medicinal

Pharmacokinetics, Safety, and Tolerability of Single and Multiple Doses of ABT-493: A First-In-Human Study

Chih-Wei Lin et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Article Cell Biology

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Review Biochemistry & Molecular Biology

Zika Virus Protease: An Antiviral Drug Target

CongBao Kang et al.

TRENDS IN MICROBIOLOGY (2017)

Review Medicine, Research & Experimental

The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review

Sheila V. Graham

CLINICAL SCIENCE (2017)

Article Chemistry, Medicinal

Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease

Jonathan E. Gable et al.

CHEMMEDCHEM (2016)

Review Microbiology

Approved Antiviral Drugs over the Past 50 Years

Erik De Clercq et al.

CLINICAL MICROBIOLOGY REVIEWS (2016)

Article Pharmacology & Pharmacy

Elbasvir/Grazoprevir: First Global Approval

Gillian M. Keating

DRUGS (2016)

Article Chemistry, Medicinal

Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS

Arun K. Ghosh et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Gastroenterology & Hepatology

GS-9857 in patients with chronic hepatitis C virus genotype 1-4 infection: a randomized, double-blind, dose-ranging phase 1 study

M. Rodriguez-Torres et al.

JOURNAL OF VIRAL HEPATITIS (2016)

Article Multidisciplinary Sciences

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren et al.

NATURE (2016)

Article Microbiology

Highly heterogeneous mutation rates in the hepatitis C virus genome

Ron Geller et al.

NATURE MICROBIOLOGY (2016)

Review Pharmacology & Pharmacy

The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development

Dahai Luo et al.

ANTIVIRAL RESEARCH (2015)

Article Pharmacology & Pharmacy

The evolution of three decades of antiretroviral therapy: challenges, triumphs and the promise of the future

Alice Tseng et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

Cobicistat: Review of a Pharmacokinetic Enhancer for HIV Infection

Elizabeth M. Sherman et al.

CLINICAL THERAPEUTICS (2015)

Review Chemistry, Medicinal

Highly resistant HIV-1 proteases and strategies for their inhibition

Irene T. Weber et al.

FUTURE MEDICINAL CHEMISTRY (2015)

Article Virology

Prevalence of HCV NS3 pre-treatment resistance associated amino acid variants within a Scottish cohort

Samantha J. Shepherd et al.

JOURNAL OF CLINICAL VIROLOGY (2015)

Article Gastroenterology & Hepatology

Safety profile of boceprevir and telaprevir in chronic hepatitis C: Real world experience from HCV-TARGET

Stuart C. Gordon et al.

JOURNAL OF HEPATOLOGY (2015)

Article Chemistry, Medicinal

Applications of Fluorine in Medicinal Chemistry

Eric P. Gillis et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Virology

Retroviral proteases and their roles in virion maturation

Jan Konvalinka et al.

VIROLOGY (2015)

Article Food Science & Technology

Induction of Suicidal Erythrocyte Death by Nelfinavir

Rosi Bissinger et al.

TOXINS (2015)

Article Chemistry, Medicinal

Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor

Asa Rosenquist et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Virology

Nelfinavir Inhibits Maturation and Export of Herpes Simplex Virus 1

Nene N. Kalu et al.

JOURNAL OF VIROLOGY (2014)

Article Virology

Induced Maturation of Human Immunodeficiency Virus

Simone Mattei et al.

JOURNAL OF VIROLOGY (2014)

Article Multidisciplinary Sciences

Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir

Hironori Hayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Temporal Response of the Human Virome to Immunosuppression and Antiviral Therapy

Iwijn De Vlaminck et al.

Review Pharmacology & Pharmacy

Simeprevir for the treatment of chronic hepatitis C

David M. You et al.

EXPERT OPINION ON PHARMACOTHERAPY (2013)

Article Microbiology

Mutations in HIV-1 gag and pol Compensate for the Loss of Viral Fitness Caused by a Highly Mutated Protease

Milan Kozisek et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)

Review Infectious Diseases

The first wave: HCV NS3 protease inhibitors telaprevir and boceprevir

Kristen M. Marks et al.

ANTIVIRAL THERAPY (2012)

Article Biochemistry & Molecular Biology

Activity, Specificity, and Probe Design for the Smallpox Virus Protease K7L

Alexander E. Aleshin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Gastroenterology & Hepatology

Antiviral strategies in hepatitis C virus infection

Christoph Sarrazin et al.

JOURNAL OF HEPATOLOGY (2012)

Review Pharmacology & Pharmacy

Discovery of boceprevir, a direct-acting NS3/4A protease inhibitor for treatment of chronic hepatitis C infections

Srikanth Venkatraman

TRENDS IN PHARMACOLOGICAL SCIENCES (2012)

Article Chemistry, Medicinal

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Steven Harper et al.

ACS MEDICINAL CHEMISTRY LETTERS (2012)

News Item Pharmacology & Pharmacy

Two drugs approved for chronic hepatitis C infection

Kate Traynor

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2011)

Article Pharmacology & Pharmacy

Boceprevir: A Protease Inhibitor for the Treatment of Chronic Hepatitis C

Bryce S. Foote et al.

ANNALS OF PHARMACOTHERAPY (2011)

Meeting Abstract Gastroenterology & Hepatology

TELAPREVIR-BASED REGIMENS SUBSTANTIALLY IMPROVED SVR RATES ACROSS ALL IL28B GENOTYPES IN THE ADVANCE TRIAL

Ira M. Jacobson et al.

GASTROENTEROLOGY (2011)

Article Biochemistry & Molecular Biology

Accessory Mutations Maintain Stability in Drug-Resistant HIV-1 Protease

Max W. Chang et al.

JOURNAL OF MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Enzyme Inhibition by Allosteric Capture of an Inactive Conformation

Gregory M. Lee et al.

JOURNAL OF MOLECULAR BIOLOGY (2011)

Article Biotechnology & Applied Microbiology

Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus

Ann D. Kwong et al.

NATURE BIOTECHNOLOGY (2011)

Article Multidisciplinary Sciences

Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors

John M. Louis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Coronaviruses An RNA proofreading machine regulates replication fidelity and diversity

Mark R. Denison et al.

RNA BIOLOGY (2011)

Article Medicine, Research & Experimental

Origins of HIV and the AIDS Pandemic

Paul M. Sharp et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2011)

Review Pharmacology & Pharmacy

Pegylated interferon and ribavirin treatment for hepatitis C virus infection

Emilio Palumbo

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2011)

Review Pharmacology & Pharmacy

Fifteen years of HIV Protease Inhibitors: raising the barrier to resistance

Annemarie M. J. Wensing et al.

ANTIVIRAL RESEARCH (2010)

Review Pharmacology & Pharmacy

Clinical management of HIV-1 resistance

Roger Paredes et al.

ANTIVIRAL RESEARCH (2010)

Review Pharmacology & Pharmacy

The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic

Samuel Broder

ANTIVIRAL RESEARCH (2010)

Article Pharmacology & Pharmacy

Pharmacokinetics and Pharmacodynamics of GS-9350: A Novel Pharmacokinetic Enhancer Without Anti-HIV Activity

A. A. Mathias et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2010)

Article Gastroenterology & Hepatology

Rapid HCV-RNA Decline With Once Daily TMC435: A Phase I Study in Healthy Volunteers and Hepatitis C Patients

Henk W. Reesink et al.

GASTROENTEROLOGY (2010)

Article Cardiac & Cardiovascular Systems

HIV protease inhibitors elicit volume-sensitive Cl- current in cardiac myocytes via mitochondrial ROS

Wu Deng et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)

Article Chemistry, Medicinal

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor

Ashok Arasappan et al.

ACS MEDICINAL CHEMISTRY LETTERS (2010)

Review Chemistry, Multidisciplinary

THERAPEUTIC TARGETS FOR INFLUENZA - PERSPECTIVES IN DRUG DEVELOPMENT

Tatana Majerova et al.

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS (2010)

Article Oncology

Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells

Ansgar Bruning et al.

BREAST CANCER RESEARCH (2010)

Article Microbiology

In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

Tse-I Lin et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)

Review Virology

Current and Novel Inhibitors of HIV Protease

Jana Pokorna et al.

VIRUSES-BASEL (2009)

Article Microbiology

Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

Scott D. Seiwert et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)

Article Instruments & Instrumentation

Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034

Vincent Madison et al.

JOURNAL OF SYNCHROTRON RADIATION (2008)

Article Multidisciplinary Sciences

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

Kiira Ratia et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Immunology

Toxicity of HIV protease inhibitors: clinical considerations

Christoph Boesecke et al.

CURRENT OPINION IN HIV AND AIDS (2008)

Article Pharmacology & Pharmacy

Atazanavir/ritonavir: A review of its use in HIV therapy

Nils von Hentig

DRUGS OF TODAY (2008)

Review Chemistry, Multidisciplinary

Design of HIV protease inhibitors targeting protein backbone: An effective strategy for combating drug resistance

Arun K. Ghosh et al.

ACCOUNTS OF CHEMICAL RESEARCH (2008)

Article Biochemistry & Molecular Biology

Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV

Arun K. Ghosh et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Chemistry, Medicinal

Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics

Robert B. Perni et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Article Medicine, General & Internal

A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism

Monique Nijhuis et al.

PLOS MEDICINE (2007)

Review Pharmacology & Pharmacy

Clinical pharmacokinetics of darunavir

Michael Rittweger et al.

CLINICAL PHARMACOKINETICS (2007)

Article Virology

Non-infectious fluorimetric assay for phenotyping of drug-resistant HIV proteinase mutants

T Majerová-Uhlíková et al.

JOURNAL OF CLINICAL VIROLOGY (2006)

Article Biochemistry & Molecular Biology

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus

P Erbel et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Review Pharmacology & Pharmacy

Fosamprenavir - Clinical pharmacokinetics and drug interactions of the amprenavir prodrug

MB Wire et al.

CLINICAL PHARMACOKINETICS (2006)

Article Chemistry, Medicinal

Inhibitors of hepatitis C virus NS3•4A protease.: Part 3:: P2 proline variants

RB Perni et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)

Article Chemistry, Medicinal

Inhibitors of hepatitis C virus NS3•4A protease 2.: Warhead SAR and optimization

RB Perni et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)

Review Pharmacology & Pharmacy

Atazanavir for the treatment of human immunodeficiency virus infection

AJ Busti et al.

PHARMACOTHERAPY (2004)

Article Virology

Herpesvirus protease inhibition by dimer disruption

N Shimba et al.

JOURNAL OF VIROLOGY (2004)

Article Virology

Antiviral drugs in current clinical use

E De Clercq

JOURNAL OF CLINICAL VIROLOGY (2004)

Article Chemistry, Medicinal

Inhibitors of hepatitis C virus NS3•4A protease 1.: Non-charged tetrapeptide variants

RB Perni et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)

Article Endocrinology & Metabolism

HIV protease inhibitors acutely impair glucose-stimulated insulin release

JC Koster et al.

DIABETES (2003)

Article Biochemistry & Molecular Biology

Structural and biochemical studies of inhibitor binding to human cytomegalovirus protease

R Khayat et al.

BIOCHEMISTRY (2003)

Review Infectious Diseases

Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance

S Spira et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2003)

Article Pharmacology & Pharmacy

Atazanavir

DR Goldsmith et al.

DRUGS (2003)

Article Biochemistry & Molecular Biology

Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains

J Weber et al.

JOURNAL OF MOLECULAR BIOLOGY (2002)

Article Pharmacology & Pharmacy

Atazanavir: a novel HIV-1 protease inhibitor

PJ Piliero

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2002)

Review Biochemistry & Molecular Biology

Recent advances in the molecular biology of Hepatitis C virus

S Rosenberg

JOURNAL OF MOLECULAR BIOLOGY (2001)

Review Multidisciplinary Sciences

Initial sequencing and analysis of the human genome

ES Lander et al.

NATURE (2001)

Review Pharmacology & Pharmacy

Genetic risks of antiviral nucleoside analogues - a survey

P Wutzler et al.

ANTIVIRAL RESEARCH (2001)