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The Adenylate Cyclase Toxins of Bacillus anthracis and Bordetella pertussis Promote Th2 Cell Development by Shaping T Cell Antigen Receptor Signaling
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PLOS PATHOGENS (2009)
ChlaDub1 of Chlamydia trachomatis suppresses NF-κB activation and inhibits IκBα ubiquitination and degradation
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CELLULAR MICROBIOLOGY (2008)
Caspase-1 activation in macrophages infected with Yersinia pestis KIM requires the type III secretion system effector YopJ
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INFECTION AND IMMUNITY (2008)
A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model
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INNATE IMMUNITY (2008)
Homeostatic MyD88-dependent signals cause lethal inflammation in the absence of A20
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Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8
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Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication
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Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-κB, suppresses IκBα ubiquitination and modulates innate immune responses
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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
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NATURE (2008)
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-κB inhibitor A20
Beatrice Coornaert et al.
NATURE IMMUNOLOGY (2008)
The proteolytic activity of the paracaspase MALT1 is key in T cell activation
Fabien Rebeaud et al.
NATURE IMMUNOLOGY (2008)
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
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NATURE IMMUNOLOGY (2008)
Toll-like receptors - taking an evolutionary approach
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NATURE REVIEWS GENETICS (2008)
Cathepsin K-dependent Toll-like receptor 9 signaling revealed in experimental arthritis
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SCIENCE (2008)
HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation
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Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function
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HEPATOLOGY (2008)
Viral evasion and subversion of pattern-recognition receptor signalling
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YopJ targets TRAF proteins to inhibit TLR-mediated NF-κB, MAPK and IRF3 signal transduction
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CELLULAR MICROBIOLOGY (2007)
Tumor Suppressor CYLD Acts as a Negative Regulator for Non-Typeable Haemophilus influenza-Induced Inflammation in the Middle Ear and Lung of Mice
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Highly-purified Helicobacter pylori LPS preparations induce weak inflammatory reactions and utilize Toll-like receptor 2 complex but not Toll-like receptor 4 complex
Shin-ichi Yokota et al.
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY (2007)
Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines
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JOURNAL OF VIROLOGY (2007)
Chlamydial CT441 is a PDZ domain-containing tail-specific protease that interferes with the NF-κB pathway of immune response
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JOURNAL OF BACTERIOLOGY (2007)
Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination
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AMERICAN JOURNAL OF PATHOLOGY (2007)
Limited suppression of the interferon-β production by hepatitis C virus serine protease in cultured human hepatocytes
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FEBS JOURNAL (2007)
Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63
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Toll-like receptors and type I interferons
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Ubiquitin-mediated activation of TAK1 and IKK
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ONCOGENE (2007)
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Melanie M. Brinkmann et al.
JOURNAL OF CELL BIOLOGY (2007)
ElaD, a Deubiquitinating Protease Expressed by E. coli
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PLOS ONE (2007)
MDA-5 is cleaved in poliovirus-infected cells
Paola M. Barral et al.
JOURNAL OF VIROLOGY (2007)
Anthrax toxins inhibit immune cell chemotaxis by perturbing chemokine receptor signalling
Silvia Rossi Paccani et al.
CELLULAR MICROBIOLOGY (2007)
Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis
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CELL CYCLE (2007)
Essential role for caspase-8 in toll-like receptors and NFκB signaling
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
SseL, a Salmonella deubiquitinase required for macrophage killing and virulence
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Cleavage of p65/Re1A of the NF-κB pathway by Chlamydia
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Manipulation of the toll-like receptor 7 signaling pathway by Epstein-Barr virus
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JOURNAL OF VIROLOGY (2007)
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
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NATURE REVIEWS GENETICS (2006)
Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection
Shahram Misaghi et al.
MOLECULAR MICROBIOLOGY (2006)
Bacillus anthracis toxins inhibit human neutrophil NADPH oxidase activity
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JOURNAL OF IMMUNOLOGY (2006)
Proteasome-mediated regulation of CpG DNA- and peptidoglycan-induced cytokines, inflammatory genes, and mitogen-activated protein kinase activation
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SHOCK (2006)
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
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NATURE IMMUNOLOGY (2006)
Yersinia outer protein P suppresses TGF-β-activated kinase-1 activity to impair innate immune signaling in Yersinia enterocolitica-infected cells
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JOURNAL OF IMMUNOLOGY (2005)
The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 and TRAF7
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Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation
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JOURNAL OF EXPERIMENTAL MEDICINE (2005)
TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Human neutrophils kill Bacillus anthracis
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Cytokine induction by the hepatitis B virus capsid in macrophages is facilitated by membrane heparan sulfate and involves TLR2
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Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-κB activation and IFN-β synthesis downstream of Toll-like receptor 3 and 4
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EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
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BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor
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Impaired functional capacities of liver dendritic cells from murine hepatitis B virus (HBV) carriers: relevance to low HBV-specific immune responses
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Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
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SCIENCE (2004)
Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria
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IMMUNOLOGY (2004)
Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases
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JOURNAL OF PATHOLOGY (2004)
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
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NATURE IMMUNOLOGY (2004)
Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium
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JOURNAL OF IMMUNOLOGY (2004)
Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner
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EUROPEAN JOURNAL OF IMMUNOLOGY (2004)
A20 inhibits toll-like receptor 2-and 4-mediated interleukin-8 synthesis in airway epithelial cells
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AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2004)
Porphyromonas gingivalis lipopolysaccharide contains multiple lipid a species that functionally interact with both toll-like receptors 2 and 4
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INFECTION AND IMMUNITY (2004)
Flagellin acting via TLR5 is the major-activator of key signaling pathways leading to NF-κB and proinflammatory gene program activation in intestinal epithelial cells -: art. no. 33
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BMC MICROBIOLOGY (2004)
Involvement of domain II in toxicity of anthrax lethal factor
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Toll-like receptors as key mediators in innate antifungal immunity
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MEDICAL MYCOLOGY (2004)
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Biology of Toll receptors: lessons from insects and mammals
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Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Identification of Escherichia coli O157:H7 genes influencing colonization of the bovine gastrointestinal tract using signature-tagged mutagenesis
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MICROBIOLOGY-SGM (2004)
Loss of lipopolysaccharide receptor CD14 from the surface of human macrophage-like cells mediated by Porphyromonas gingivalis outer membrane vesicles
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MICROBIAL PATHOGENESIS (2004)
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JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Leucine-rich repeats and pathogen recognition in Toll-like receptors
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TRENDS IN IMMUNOLOGY (2003)
The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination
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NATURE (2003)
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ARCHIVES OF MICROBIOLOGY (2003)
Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved
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PI3K in lymphocyte development, differentiation and activation
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Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2
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Saquinavir - A review of its use in boosted regimens for treating HIV infection
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β-catenin interacts with and inhibits NF-κB in human colon and breast cancer
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SCIENCE (2002)
Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-κB pathway
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Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
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NATURE IMMUNOLOGY (2002)
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CELLULAR MICROBIOLOGY (2002)
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INTERNATIONAL IMMUNOLOGY (2001)
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
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NATURE IMMUNOLOGY (2001)
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INTERNATIONAL IMMUNOPHARMACOLOGY (2001)
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Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin
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NATURE (2000)
Toll-like receptor 2-mediated NF-κB activation requires a RacI-dependent pathway
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NATURE IMMUNOLOGY (2000)
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SCIENCE (2000)
Proteolysis of human monocyte CD14 by cysteine proteinases (Gingipains) from Porphyromonas gingivalis leading to lipopolysaccharide hyporesponsiveness
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JOURNAL OF IMMUNOLOGY (2000)
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