Journal
CELL
Volume 161, Issue 5, Pages 971-987Publisher
CELL PRESS
DOI: 10.1016/j.cell.2015.05.019
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Funding
- Novo Nordisk Foundation
- National Institutes of Health [R01 GM057089]
- NNF Center for Biosustainability [Network Reconstruction] Funding Source: researchfish
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
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Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have been under development since the first whole-genome sequences appeared in the mid-1990s. A few years ago, this approach began to demonstrate the ability to predict a range of cellular functions, including cellular growth capabilities on various substrates and the effect of gene knockouts at the genome scale. Thus, much interest has developed in understanding and applying these methods to areas such as metabolic engineering, antibiotic design, and organismal and enzyme evolution. This Primer will get you started.
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