Radiation dose estimates based on Monte Carlo simulation for spiral breast computed tomography imaging in a large cohort of patients

BackgroundSpiral breast computed tomography (BCT) equipped with a photon-counting detector (PCD) is a new radiological modality allowing for the compression-free acquisition of high-resolution 3-D datasets of the breast. Optimized dose exposu04170/re setups according to breast size were previously proposed but could not effectively be applied in a clinical environment due to ambiguity in measuring breast size. PurposeThis study aims to report the standard radiation dose values in a large cohort of patients examined with BCT, and to provide a mathematical model to estimate radiation dose based on morphological features of the breast. MethodsThis retrospective study was conducted on 1657 BCT examinations acquired between 2018 and 2021 from 829 participants (57 +/- 10 years, all female). Applying a dedicated breast tissue segmentation algorithm and Monte Carlo (MC) simulation, mean absorbed dose (MAD), mean glandular dose (MGD), mean skin dose (MSD), maximum glandular dose (maxGD), and maximum skin dose (maxSD) were calculated and related to morphological features such as breast volume, effective diameter, breast length, skin volume, and glandularity. Effective dose (ED) was calculated by applying the corresponding beam and tissue weighting factors, 1 Sv/Gy and 0.12 per breast. Relevant morphological features predicting dose values were identified based on the Spearman's rank correlation coefficient. Exponential or bi-exponential models predicting the dose values as a function of morphological features were fitted by using a non-linear least squares (LS) method. The models were validated by assessing R-2 and residual standard error (RSE). ResultsThe most relevant morphological features for radiation dose estimation were the breast volume (correlation coefficient: -0.8), diameter (-0.7), and length (-0.6). The glandularity presented a weak-positive correlation (0.4) with MGD and maxGD due to the inhomogeneous distribution of the glandularity and absorbed dose in the 3-D breast volume. The standard MGDs were calculated to be 7.3 +/- 0.7, 6.5 +/- 0.3, and 5.9 +/- 0.3 mGy, MADs to 7.6 +/- 0.8, 6.8 +/- 0.3, and 6.2 +/- 0.3 mGy, maxSDs to 19.9 +/- 1.6, 19.5 +/- 0.5, and 18.9 +/- 0.5 mGy, and EDs to 0.88 +/- 0.08, 0.78 +/- 0.04, and 0.72 +/- 0.04 mSv for small, medium, and large breasts with average breast lengths of 5.9 +/- 1.6, 8.7 +/- 1.3, and 12.2 +/- 2.0 cm, respectively. The estimated glandularity - 23.1 +/- 16.9, 12.5 +/- 11.4, and 6.9 +/- 7.3% from small to large breasts. The mathematical models were able to estimate the MAD, MGD, MSD, and maxSD as a function of each morphological feature with only upto 0.5 mGy RSE. ConclusionWe presented the typical morphological features and standard dose values according to the breast size acquired from a large patient cohort. We established radiation dose estimation models allowing accurate estimation of dose values including MGD with an acceptable RSE based on each of the easily measured morphological features of the breast. Clinicians could use the breast length to operate as a dosimetric alert of the scanner prior to a BCT scan. Radiation exposure for BCT was lower than diagnostic mammography (MG) and cone-beam breast CT (BCT).

Automated summary

This study aims to report the standard radiation dose values in a large cohort of patients examined with BCT and provide a mathematical model to estimate radiation dose based on morphological features of the breast. The breast length can be used as a dosimetric alert prior to a BCT scan. The radiation exposure for BCT was lower than diagnostic mammography (MG) and cone-beam breast CT (BCT).