Journal
MEDICAL MOLECULAR MORPHOLOGY
Volume 56, Issue 1, Pages 58-68Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s00795-022-00340-x
Keywords
Peripartum cardiomyopathy; Pregnancy; Delivery; Myocarditis; Hypertension; Pathology
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The etiology of peripartum cardiomyopathy (PPCM) is varied and related to myocarditis and myocardial overload due to hypertension, as revealed by endomyocardial biopsy.
The etiology of peripartum cardiomyopathy (PPCM) is unknown. Therefore, we evaluated the etiology of patients clinically diagnosed with PPCM using endomyocardial biopsy. We studied five patients diagnosed with PPCM following endomyocardial biopsy (age, 28-42 years; mean age, 35 years). Biopsied samples were evaluated using microscopy, including immunostaining and electron microscopy. The pathological findings were as follows: myocardial hypertrophy, myocardial fibrosis, and cell infiltration. Two patients were diagnosed with lymphocytic myocarditis, one with eosinophilic myocarditis, one with hypertensive heart disease, and one with a combination of hypertension and myocarditis. Endomyocardial biopsy suggested that the causes of PPCM were varied and related to myocarditis and myocardial overload due to hypertension.
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