The benefits of physical activity in middle-aged individuals for cardiovascular disease outcomes

Regular physical activity (PA) has a positive role in preventing cardiovascular disease (CVD). Due to a trend toward a more sedentary lifestyle, the middle-aged population (35-65 years) is at greater risk of developing CVD. It is well established that PA improves cardiorespiratory fitness and reduces the risk of cardiovascular mortality and cardiovascular events, including stroke, coronary heart disease, heart failure, hypercholesterolemia, atherosclerosis, diabetes, and blood pressure. PA can potentially decrease oxidative stress and systemic inflammation, which are the two main underlying mechanisms leading to CVD. By reducing CRP, TNF-alpha, INF-gamma, NF-KB and increasing IL-10, IL-4, and IL-8, PA can prevent the initiation and progression of CVD in middle-aged adults, highlighting the importance of being physically active for this age group. The general recommendation for PA to prevent CVD is at least 150 min/week at a moderate level of intensity; the type of PA should be adapted to the fitness level and medical condition of the individual. However, standardized guidelines for middle-aged individuals with cardiovascular events still need to be established.

Automated summary

Regular physical activity has a positive role in preventing cardiovascular disease, especially for middle-aged individuals. It improves cardiorespiratory fitness, reduces the risk of cardiovascular events, and decreases oxidative stress and inflammation, which are the main mechanisms of CVD. The general recommendation for middle-aged adults is at least 150 minutes per week of moderate-intensity physical activity.